scholarly journals Parathyroid Chief Cell Hyperplasia

2020 ◽  
Author(s):  
Keyword(s):  
1971 ◽  
Vol 285 (24) ◽  
pp. 1365-1366 ◽  
Author(s):  
A. Robert Arnstein ◽  
Irwin K. Rosenberg ◽  
Juan Belamaric ◽  
James M. Pierce ◽  
Daisy McCann ◽  
...  

Parasitology ◽  
1998 ◽  
Vol 116 (6) ◽  
pp. 569-577 ◽  
Author(s):  
I. SCOTT ◽  
M. J. STEAR ◽  
J. IRVINE ◽  
A. DICK ◽  
D. S. WALLACE ◽  
...  

The effects of dietary urea supplementation and of a 10-week trickle infection regime, simulating chronic exposure to Haemonchus contortus, on the zymogenic population of the abomasa of Hampshire Down lambs was examined. At necropsy a variety of parameters including plasma pepsinogen concentrations, the wet weights of abomasal fundic mucosal pieces and the amounts of pepsinogen contained in them, were assessed. Tissue pepsinogen concentration was measured as the total, acid-stable proteolytic activity present in mucosal homogenates, as well as immunohistochemically. The immunohistochemical findings were quantified using computer-aided image analysis. Elevation of plasma pepsinogen concentrations in infected animals was of borderline significance (P=0·06). The fundic mucosae of infected animals were heavier (P<0·02) than those of control animals, but there was no overall change in the pepsinogen content of tissues. Immunohistochemistry revealed that infected animals had increased numbers of zymogenic cells, due to mucous cell hyperplasia and the adaptation of cells to produce both mucins and pepsinogen. The pepsinogen content of chief cells, the major source of pepsinogen in uninfected animals, was reduced in infected lambs. Image analysis confirmed that at a mid-point of the mucosa of infected animals there was increased pepsinogen-specific immunoreactivity that corresponded with areas of mucosal hyperplasia. Mucous cell hyperplasia might therefore allow the maintenance of pepsinogen secretion in infected animals even if chief cell output is reduced.


2020 ◽  
Vol 40 (11) ◽  
pp. 831-836
Author(s):  
Mizael Machado ◽  
Carlos O. Schild ◽  
Marcela Preliasco ◽  
Aldana Balserini ◽  
Rosane M.T. Medeiros ◽  
...  

ABSTRACT: This study aimed to do a brief review of enzootic calcinosis in sheep and to report two outbreaks of Nierembergia rivularis poisoning in sheep in Uruguay. The outbreaks occurred in farms located on an island (Outbreak A) and on the border (Outbreak B) of the Rincón del Bonete lake. Sheep of all ages were affected, with the exception of suckling lambs. The first clinical signs occurred in early October, and deaths occurred from December to February. Outbreaks A and B had morbidity of 10%, and the mortality was 7.2% and 2.8% in Outbreaks A and B, respectively. The clinical signs included weight loss, retracted abdomen, stiff gait, and kyphosis. An autopsy was performed on one sheep from each outbreak. Pulmonary and arterial calcification, nephrocalcinosis, and osteopetrosis were observed in gross and microscopic examination in both sheep. Thyroid C-cell hyperplasia and carcinoma was observed in sheep A. Sheep B showed thyroid C-cell hyperplasia and parathyroid chief cell atrophy. The parathyroid was not examined in the sheep from Outbreak A. The differential diagnosis of enzootic calcinosis in southern South America should consider four toxic plants in the Solanaceae family: Solanum glaucophyllum, Solanum stuckertii, Nierembergia veitchii, and Nierembergia rivularis.


1958 ◽  
Vol 148 (3) ◽  
pp. 375-388 ◽  
Author(s):  
OLIVER COPE ◽  
W. MILO KEYNES ◽  
SANFORD I. ROTH ◽  
BENJAMIN CASTLEMAN

2005 ◽  
Vol 200 (11-12) ◽  
pp. 817-821 ◽  
Author(s):  
Akihiro Matsukawa ◽  
Ryoichi Kurano ◽  
Takahiro Takemoto ◽  
Motoko Kagayama ◽  
Takaaki Ito

1970 ◽  
Vol 53 (5) ◽  
pp. 565-579 ◽  
Author(s):  
William C. Black ◽  
Roderick C. Haff

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