scholarly journals Densely Granulated Somatotroph Adenoma

2020 ◽  
Author(s):  
Keyword(s):  
Somatotroph Adenoma

Aggressive Sparsely Granulated Somatotroph Adenoma of the Pituitary Responding Favorably to Temozolomide

2011 ◽  
pp. OR36-6-OR36-6
Author(s):  
Caroline Steele ◽  
Federico Roncaroli ◽  
Atik Baborie ◽  
Nelofer Syed ◽  
David Husband ◽  
...  
Keyword(s):  
Somatotroph Adenoma

Endocrine and morphological study of a clinically silent somatotroph adenoma of the human pituitary.

1993 ◽  
Vol 76 (2) ◽  
pp. 352-356 ◽  
Author(s):  
S Yamada ◽  
T Sano ◽  
L Stefaneanu ◽  
K Kovacs ◽  
T Aiba ◽  
...  
Keyword(s):  
Morphological Study ◽  
Human Pituitary ◽  
Somatotroph Adenoma

scholarly journals Mechanisms of TRH-induced GH Release (Paradoxical Response) in Human Somatotroph Adenoma Cells

2005 ◽  
Vol 52 (6) ◽  
pp. 763-767 ◽  
Author(s):  
Hiroko OKINAGA ◽  
Koji TAKANO ◽  
Shuhei HAYASHI ◽  
Junko YASUFUKU-TAKANO ◽  
Akira TERAMOTO ◽  
...  
Keyword(s):  
Somatotroph Adenoma ◽  
Paradoxical Response

scholarly journals Molecular and functional properties of densely and sparsely granulated GH-producing pituitary adenomas

2013 ◽  
Vol 169 (4) ◽  
pp. 391-400 ◽  
Author(s):  
Bernhard Mayr ◽  
Rolf Buslei ◽  
Marily Theodoropoulou ◽  
Günter K Stalla ◽  
Michael Buchfelder ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Molecular Level ◽  
Secretory Granules ◽  
Somatostatin Receptor ◽  
Receptor Subtypes ◽  
Membrane Expression ◽  
Cytoplasmic Expression ◽  
Somatotroph Adenoma ◽  
Somatostatin Receptor Subtypes

ObjectiveGH-producing pituitary adenomas display two distinct morphological patterns of cytoplasmic GH-containing secretory granules, namely the densely and sparsely granulated somatotroph adenoma subtype. It is unknown whether these morphological variants reflect distinct pathophysiological entities at the molecular level.MethodsIn 28 GH-producing adenoma tissues from a consecutive set of patients undergoing pituitary surgery for acromegaly, we studied the GH granulation pattern, the expression of somatostatin receptor subtypes (SSTR) as well as the calcium, cAMP and ZAC1 pathways in primary adenoma cell cultures.ResultsThe expression ofGSPoncogene was similar between densely and sparsely granulated somatotroph adenoma cells. There were no differences in the calcium, cAMP and ZAC1 pathways as well as in their regulation by SSTR agonists. SSTR2 was exclusively expressed in densely but not in sparsely granulated tumours (membrane expression 86 vs 0%; cytoplasmic expression 67 vs 0%). By contrast, expression of SSTR5 was only found in sparsely but not in densely granulated somatotroph adenomas (membrane expression 29 vs 0%; cytoplasmic expression 57 vs 0%).ConclusionsOur results indicate that different granulation patterns in GH-producing adenomas do not reflect differences in pathways and factors pivotal for somatotroph differentiation and function.In vitro, the vast majority of both densely and sparsely granulated tumour cells were responsive to SSTR activation at the molecular level. Sparsely granulated adenomas lacking SSTR2, but expressing SSTR5, might be responsive to novel SSTR agonists with increased affinity to SSTR5.

Mixed somatotroph adenoma-gangliocytoma: A rare sellar combined tumor

2020 ◽  
Vol 11 ◽  
pp. 1
Author(s):  
Ana Beatriz Winter Tavares ◽  
Luiz Guilherme Kraemer-Aguiar
Keyword(s):  
Somatotroph Adenoma ◽  
Combined Tumor

scholarly journals Silent Somatotroph Adenoma, Detected by Catalyzed Signal Amplification and Non-radioisotopic In situ Hybridization

1999 ◽  
Vol 46 (Suppl) ◽  
pp. S81-S84 ◽  
Author(s):  
AKIRA MATSUNO ◽  
NAOKO SANNO ◽  
SHIGEYUKI TAHARA ◽  
AKIRA TERAMOTO ◽  
R. YOSHIYUKI OSAMURA ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Signal Amplification ◽  
Somatotroph Adenoma

Cabergoline Decreases Somatotroph Adenoma Size: A Case Report

Pituitary ◽  
2004 ◽  
Vol 7 (2) ◽  
pp. 107-110 ◽  
Author(s):  
Michael R. Rickels ◽  
Peter J. Snyder
Keyword(s):  
Case Report ◽  
Somatotroph Adenoma
Sign in / Sign up

Export Citation Format

Share Document