scholarly journals Mucosal Infection

2020 ◽  
Author(s):  
Keyword(s):  
Mucosal Infection

scholarly journals Trypanosoma cruzi Entrance through Systemic or Mucosal Infection Sites Differentially Modulates Regional Immune Response Following Acute Infection in Mice

2013 ◽  
Vol 4 ◽  
Author(s):  
Juliana de Meis ◽  
Juliana Barreto de Albuquerque ◽  
Danielle Silva dos Santos ◽  
Désio Aurélio Farias-de-Oliveira ◽  
Luiz Ricardo Berbert ◽  
...  
Keyword(s):  
Immune Response ◽  
Trypanosoma Cruzi ◽  
Acute Infection ◽  
Mucosal Infection

scholarly journals Antigen-Specific Immunoglobulin A Antibodies Secreted from Circulating B Cells Are an Effective Marker for Recent Local Immune Responses in Patients with Cholera: Comparison to Antibody-Secreting Cell Responses and Other Immunological Markers

2003 ◽  
Vol 71 (8) ◽  
pp. 4808-4814 ◽  
Author(s):  
Firdausi Qadri ◽  
Edward T. Ryan ◽  
A. S. G. Faruque ◽  
Firoz Ahmed ◽  
Ashraful Islam Khan ◽  
...  
Keyword(s):  
Immune Responses ◽  
Immunoglobulin A ◽  
Peripheral Circulation ◽  
Secreting Cell ◽  
Antibody Secreting Cell ◽  
Immunological Responses ◽  
B Subunit ◽  
Mucosal Infection ◽  
Circulating Lymphocytes

ABSTRACT Gut-derived lymphocytes transiently migrate through the peripheral circulation before homing back to mucosal sites and can be detected using an ELISPOT-based antibody secreting cell (ASC) assay. Alternatively, transiently circulating lymphocytes may be cultured in vitro, and culture supernatants may be assayed for antigen-specific responses (antibody in lymphocyte supernatant [ALS] assay). The ALS assay has not been validated extensively in natural mucosal infection, nor has the ALS response been compared to the ASC assay and other cholera-specific immunological responses. Accordingly, we examined immune responses in 30 adult patients with acute cholera in Bangladesh, compared with 10 healthy controls, measuring ALS-immunoglobulin A (IgA), ASC-IgA, and serum and fecal IgA responses to two potent Vibrio cholerae immunogens, the nontoxic B subunit of cholera toxin (CtxB) and lipopolysaccharide (LPS) and a weaker V. cholerae immunogen, the mannose-sensitive hemagglutinin (MSHA). We found significant increases of anti-CtxB, anti-LPS, and anti-MSHA IgA in supernatants of lymphocytes cultured 7 days after onset of cholera using the ALS assay. We found that ALS and ASC responses correlated extremely well; both had comparable sensitivities as the vibriocidal responses, and both procedures were more sensitive than fecal IgA measurements. An advantage of the ALS assay for studying mucosal immune responses is the ability to freeze antibodies in supernatants for subsequent evaluation; like the ASC assay, the ALS assay can distinguish recent from remote mucosal infection, a distinction that may be difficult to make in endemic settings using other procedures.

scholarly journals Lactiplantibacillus plantarum as a Potential Adjuvant and Delivery System for the Development of SARS-CoV-2 Oral Vaccines

2021 ◽  
Vol 9 (4) ◽  
pp. 683
Author(s):  
Julio Villena ◽  
Chang Li ◽  
Maria Guadalupe Vizoso-Pinto ◽  
Jacinto Sacur ◽  
Linzhu Ren ◽  
...  
Keyword(s):  
Immune Responses ◽  
Oral Administration ◽  
Molecular Mechanisms ◽  
Spike Protein ◽  
Heterologous Proteins ◽  
Oral Vaccines ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Viral Antigens ◽  
Mucosal Infection

The most important characteristics regarding the mucosal infection and immune responses against the Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) as well as the current vaccines against coronavirus disease 2019 (COVID-19) in development or use are revised to emphasize the opportunity for lactic acid bacteria (LAB)-based vaccines to offer a valid alternative in the fight against this disease. In addition, this article revises the knowledge on: (a) the cellular and molecular mechanisms involved in the improvement of mucosal antiviral defenses by beneficial Lactiplantibacillus plantarum strains, (b) the systems for the expression of heterologous proteins in L. plantarum and (c) the successful expressions of viral antigens in L. plantarum that were capable of inducing protective immune responses in the gut and the respiratory tract after their oral administration. The ability of L. plantarum to express viral antigens, including the spike protein of SARS-CoV-2 and its capacity to differentially modulate the innate and adaptive immune responses in both the intestinal and respiratory mucosa after its oral administration, indicates the potential of this LAB to be used in the development of a mucosal COVID-19 vaccine.

Identification of Candida albicans regulatory genes governing mucosal infection

2018 ◽  
Vol 20 (8) ◽  
Author(s):  
Juliane Meir ◽  
Elena Hartmann ◽  
Marie‐Therese Eckstein ◽  
Eva Guiducci ◽  
Florian Kirchner ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Regulatory Genes ◽  
Mucosal Infection

scholarly journals Oral candidiasis-adhesion of non-albicans Candida species

2008 ◽  
pp. 69-78 ◽  
Author(s):  
Marija Bokor-Bratic
Keyword(s):  
Candida Albicans ◽  
Candida Species ◽  
Oral Candidiasis ◽  
Initial Step ◽  
Oral Microflora ◽  
Mucosal Surfaces ◽  
Buccal Epithelial Cells ◽  
Mucosal Infection ◽  
Denture Acrylics ◽  
Candida Colonisation

Oral candidiasis is an opportunistic infection caused primarily by Candida albicans. However, in recent years, species of non-albicans Candida have been implicated more frequently in mucosal infection. Candida species usually reside as commensal organisms and are part of normal oral microflora. Determining exactly how transformation from commensal to pathogen takes place and how it can be prevented is continuous challenge for clinical doctors. Candidal adherence to mucosal surfaces is considered as a critical initial step in the pathogenesis of oral candidiasis. Acrylic dentures, acting as reservoirs, play an important role in increasing the risk from Candida colonisation. Thus, this review discusses what is currently known about the adhesion of non-albicans Candida species of oral origin to buccal epithelial cells and denture acrylics.

scholarly journals The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice.

1995 ◽  
Vol 92 (14) ◽  
pp. 6499-6503 ◽  
Author(s):  
R. L. Ferrero ◽  
J. M. Thiberge ◽  
I. Kansau ◽  
N. Wuscher ◽  
M. Huerre ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Protective Immunity ◽  
Mucosal Infection
Sign in / Sign up

Export Citation Format

Share Document