scholarly journals Dysfunctional Labor

2020 ◽  
Author(s):  
Keyword(s):  
Dysfunctional Labor

Dysfunctional Labor

2012 ◽  
pp. 81-81
Author(s):  
Madhuri Patel ◽  
Priyanka Shah ◽  
Khyati Patel
Keyword(s):  
Dysfunctional Labor

Labor Dystocia: Dysfunctional Labor

2016 ◽  
pp. 306-306
Author(s):  
Sudha Salhan ◽  
Sunita Malik
Keyword(s):  
Labor Dystocia ◽  
Dysfunctional Labor

Dysfunctional Labor

2011 ◽  
pp. 1169-1183.e2
Author(s):  
Harry Gee
Keyword(s):  
Dysfunctional Labor

scholarly journals Progesterone and estrogen regulate NALCN expression in human myometrial smooth muscle cells

2020 ◽  
Vol 318 (4) ◽  
pp. E441-E452 ◽  
Author(s):  
Chinwendu Amazu ◽  
Xiaofeng Ma ◽  
Clara Henkes ◽  
Juan J. Ferreira ◽  
Celia M. Santi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Microarray Data ◽  
Quiescent State ◽  
Leak Current ◽  
Response Elements ◽  
Contractile State ◽  
Leak Channel ◽  
Estrogen Response ◽  
Myometrial Smooth Muscle Cell ◽  
Dysfunctional Labor

During pregnancy, the uterus transitions from a quiescent state to an excitable, highly contractile state to deliver the fetus. Two important contributors essential for this transition are hormones and ion channels, both of which modulate myometrial smooth muscle cell (MSMC) excitability. Recently, the sodium (Na+) leak channel, nonselective (NALCN), was shown to contribute to a Na+ leak current in human MSMCs, and mice lacking NALCN in the uterus had dysfunctional labor. Microarray data suggested that the proquiescent hormone progesterone (P4) and the procontractile hormone estrogen (E2) regulated this channel. Here, we sought to determine whether P4 and E2 directly regulate NALCN. In human MSMCs, we found that NALCN mRNA expression decreased by 2.3-fold in the presence of E2 and increased by 5.6-fold in the presence of P4. Similarly, E2 treatment decreased, and P4 treatment restored NALCN protein expression. Additionally, E2 significantly inhibited, and P4 significantly enhanced an NALCN-dependent leak current in MSMCs. Finally, we identified estrogen response and progesterone response elements (EREs and PREs) in the NALCN promoter. With the use of luciferase assays, we showed that the PREs, but not the ERE, contributed to regulation of NALCN expression. Our findings reveal a new mechanism by which NALCN is regulated in the myometrium and suggest a novel role for NALCN in pregnancy.

scholarly journals 798: Do adipokinins increase dysfunctional labor in obese patients by antagonizing oxytocin receptor expression?

2016 ◽  
Vol 214 (1) ◽  
pp. S416
Author(s):  
Ruchira Sharma ◽  
Kelly Kuo ◽  
Huiqing Tan ◽  
Peyvand Amini ◽  
Sam Mesiano ◽  
...  
Keyword(s):  
Oxytocin Receptor ◽  
Receptor Expression ◽  
Obese Patients ◽  
Dysfunctional Labor

Association between lactate concentration in amniotic fluid and dysfunctional labor

2008 ◽  
Vol 87 (9) ◽  
pp. 924-928 ◽  
Author(s):  
Eva Wiberg-Itzel ◽  
Hans Pettersson ◽  
Sven Cnattingius ◽  
Lennart Nordström
Keyword(s):  
Amniotic Fluid ◽  
Lactate Concentration ◽  
Dysfunctional Labor

DYSFUNCTIONAL LABOR. IV. COMBINED ABERRANT DILATATION PATTERNS IN THE NULLIPARA

1963 ◽  
Vol 18 (3) ◽  
pp. 383-385
Author(s):  
Emanuel A. Friedman ◽  
Marlene R. Sachtleben
Keyword(s):  
Dysfunctional Labor

Outcome of normal and dysfunctional labor in different racial groups

1979 ◽  
Vol 135 (4) ◽  
pp. 495-498 ◽  
Author(s):  
Margaret H. Thom ◽  
K.K. Chan ◽  
J.W.W. Studd
Keyword(s):  
Racial Groups ◽  
Dysfunctional Labor
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