scholarly journals Cellular Schwannoma

2020 ◽  
Author(s):  
Keyword(s):  
Cellular Schwannoma

Plexiform Cellular Schwannoma in Infancy and Childhood: A Clinicopathological Study of Seven Cases of an Underrecognized Nerve Sheath Tumor with a Tendency Toward Local Recurrence

2021 ◽  
pp. 106689692110522
Author(s):  
Meng Sun ◽  
Mengyuan Shao ◽  
Jiahan Liu ◽  
Lu Zhao ◽  
I Weng Lao ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Growth Pattern ◽  
S100 Protein ◽  
Maximum Diameter ◽  
Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Thoracic Spinal ◽  
Infancy And Childhood ◽  
Eosinophilic Cytoplasm ◽  
Cellular Schwannoma

Plexiform cellular schwannoma (PCS) is very rare, and it is not completely understood. We present our experience with 7 additional cases of PCS in infancy and childhood to further characterize its distinctive clinicopathological features. There were 5 females and 2 males with a mean age of 28 months (ranging, 2 months to 8 years). The involved sites included the left forearm ( n = 2), sacrococcygeal region ( n = 2), retroperitoneum ( n = 1), thoracic spinal canal and thoracic cavity ( n = 1), and neck ( n = 1). Tumor sizes ranged from 3 to 13 cm in maximum diameter (mean, 7.1 cm). Histologically, all tumors consisted of abundant spindle cells arranged in a multinodular or plexiform growth pattern, possessing elongated, hyperchromatic nuclei and pale eosinophilic cytoplasm with indistinct cell margins. Mitotic figures were easily identified, with a mean count of 4 per 10 consecutive high power fields (HPF). Immunohistochemically, all tumors were strongly and diffusely positive for S100 protein, SOX10 and H3K27me3. The Ki-67 index ranged from 5% to 30% (mean, 15%). Follow-up (available in 6 cases) revealed that 5 patients experienced local recurrence and were treated by re-excision. There was no evidence of recurrence and metastasis in 3 patients, and the other 2 were alive with the disease. In conclusion, PCS is an uncommon nerve sheath tumor predominantly occurring in infants and children, featuring a plexiform or multinodular growth pattern and exhibiting a tendency toward local recurrence. PCS is easily mistaken as malignant peripheral nerve sheath tumor (MPNST) due to its locally aggressive behaviors and worrisome features, including hypercellularity, hyperchromatism and high proliferative activity. Increased awareness of its potential occurrence and greater familiarity with its characteristic features are helpful for both clinicians and pathologists to avoid misdiagnosis and unnecessary overtreatment.

scholarly journals Solitary cellular schwannoma presenting with haemothorax

1998 ◽  
Vol 91 (11) ◽  
pp. 596-597 ◽  
Author(s):  
M H M Lee ◽  
A N J Graham ◽  
A G Nicholson ◽  
U Pastorino
Keyword(s):  
Cellular Schwannoma

Cellular schwannoma of the hand

1989 ◽  
Vol 14 (5) ◽  
pp. 907-909 ◽  
Author(s):  
Stephen F. Davidson ◽  
Suman K. Das ◽  
Edward E. Smith
Keyword(s):  
Cellular Schwannoma

Spinal malignant nerve-sheath tumor or cellular schwannoma? A striking difference in prognosis

1993 ◽  
Vol 79 (4) ◽  
pp. 528-532 ◽  
Author(s):  
Matti T. Seppälä ◽  
Matti J. J. Haltia
Keyword(s):  
Malignant Tumors ◽  
Spinal Tumors ◽  
Striking Difference ◽  
Malignant Neoplasms ◽  
Nerve Sheath Tumor ◽  
Content Type ◽  
Nerve Sheath Tumors ◽  
Nerve Sheath ◽  
Cellular Schwannoma ◽  
S 100

✓ Cellular schwannoma, a recently delineated entity, has a histological appearance mimicking that of malignant neoplasms. The aim of this study was to determine the outcome for patients treated for a spinal cellular schwannoma or malignant nerve-sheath tumor. A histological re-examination was conducted of 283 spinal tumors, considered to originate from a nerve root, that were treated in the Department of Neurosurgery between 1953 and 1985. After re-examination, 50 of these were determined to be other tumors or nonneoplastic lesions. The review yielded eight cellular schwannomas and six malignant nerve-sheath tumors out of 233 of nerve-sheath origin. Immunohistochemical staining with a commercially available polyclonal antibody against S-100 protein was positive in all cases of cellular schwannoma, but negative for the malignant tumors. Clinical outcome was favorable for patients with cellular schwannomas, but uniformly poor for those with the malignant tumors.

Congenital and Childhood Plexiform (Multinodular) Cellular Schwannoma

2003 ◽  
Vol 27 (10) ◽  
pp. 1321-1329 ◽  
Author(s):  
James M. Woodruff ◽  
Bernd W. Scheithauer ◽  
Özlem Kurtkaya-Yapcer ◽  
Corey Raffel ◽  
Sair S. Amr ◽  
...  
Keyword(s):  
Cellular Schwannoma

Retrovesical cellular schwannoma

1997 ◽  
Vol 79 (3) ◽  
pp. 473-474 ◽  
Author(s):  
J.M. Fernandez ◽  
J.F. Val-Bernal ◽  
S. Escaf ◽  
J.L. Sahagun ◽  
F. Alonso
Keyword(s):  
Cellular Schwannoma

Cellular schwannoma of the mandible: A case report

2001 ◽  
Vol 59 (7) ◽  
pp. 826-828 ◽  
Author(s):  
Melahat Öğütcen-Toller ◽  
Murat Metin ◽  
Filiz Karagöz
Keyword(s):  
Case Report ◽  
Cellular Schwannoma
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