Autologous Expanded Mesenchymal Stem Cells OTI-010

2020 ◽  
Author(s):  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Expanded Mesenchymal Stem Cells

Safety and Complications Reporting on the Re-implantation of Culture-Expanded Mesenchymal Stem Cells using Autologous Platelet Lysate Technique

2010 ◽  
Vol 5 (1) ◽  
pp. 81-93 ◽  
Author(s):  
Christopher Centeno ◽  
John Schultz ◽  
Michelle Cheever ◽  
Brent Robinson ◽  
Michael Freeman ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Platelet Lysate ◽  
Expanded Mesenchymal Stem Cells ◽  
Autologous Platelet

Treatment of faecal incontinence with autologous expanded mesenchymal stem cells: results of a pilot study

2020 ◽  
Author(s):  
Fernando Portilla ◽  
José Luis Guerrero ◽  
Maria Victoria Maestre ◽  
Laura Leyva ◽  
Santiago Mera ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Pilot Study ◽  
Faecal Incontinence ◽  
Expanded Mesenchymal Stem Cells

scholarly journals Autologous bone marrow expanded mesenchymal stem cells in patellar tendinopathy: protocol for a phase I/II, single-centre, randomized with active control PRP, double-blinded clinical trial

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Gil Rodas ◽  
Robert Soler ◽  
Ramón Balius ◽  
Xavier Alomar ◽  
Xavier Peirau ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Patellar Tendon ◽  
Autologous Bone Marrow ◽  
Patellar Tendinopathy ◽  
Single Centre ◽  
Autologous Bone ◽  
Double Blinded ◽  
Expanded Mesenchymal Stem Cells

Abstract Introduction Patellar tendon overuse injuries are common in athletes. Imaging may show a change in tissue structure with tendon thickening and disruption of the intratendinous substance. We wish to test the hypothesis that both autologous bone marrow expanded mesenchymal stem cells and autologous leukocyte-poor platelet-rich plasma (LP-PRP) implanted into the area of the disrupted tendinopathic patellar tendon will restore function, but tendon regeneration tissue will only be observed in the subjects treated with autologous bone marrow expanded mesenchymal stem cells. Methods and analysis This is a single-centre, pilot phase I/II, double-blinded clinical trial with randomisation with active control. Twenty patients with a diagnosis of patellar tendinopathy with imaging changes (tendon thickening and disruption of the intratendinous substance at the proximal portion of the patellar tendon) will be randomised in a 1:1 ratio to receive a local injection of either bone-marrow autologous mesenchymal stem cells (MSC), isolated and cultured under GMP at The Institute of Biology and Molecular Genetics (IBGM) (Spain) or P-PRP. The study will have two aims: first, to ascertain whether a clinically relevant improvement after 3, 6 and 12 months according to the visual analogue scale (VAS), Victorian Institute of Sport Assessment for patellar tendons (VISA-P) and dynamometry scales (DYN) will be achieved; and second, to ascertain whether the proposed intervention will restore tendon structure as determined by ultrasonography (US), Doppler ultrasonography (DUS), and innovative MRI and ultrasound techniques: Magnetic Resonance T2 FAT SAT (UTE, Ultrashort Echo TE) sequence and Ultrasound Tissue Characterization (UTC). Patients who are randomised to the P-PRP treatment group but do not achieve a satisfactory primary endpoint after 6 months will be offered treatment with MSC. Trial registration NCT03454737.

scholarly journals Injectable Bone Tissue Engineering Using Expanded Mesenchymal Stem Cells

Stem Cells ◽  
2013 ◽  
Vol 31 (3) ◽  
pp. 572-580 ◽  
Author(s):  
Yoichi Yamada ◽  
Sayaka Nakamura ◽  
Kenji Ito ◽  
Eri Umemura ◽  
Kenji Hara ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Expanded Mesenchymal Stem Cells

scholarly journals Regulatory authorities and orthopaedic clinical trials on expanded mesenchymal stem cells

2014 ◽  
Vol 38 (9) ◽  
pp. 1803-1809 ◽  
Author(s):  
Enrique Gómez-Barrena ◽  
Cristina Avendaño Solá ◽  
Carmen Painatescu Bunu
Keyword(s):  
Stem Cells ◽  
Clinical Trials ◽  
Mesenchymal Stem Cells ◽  
Regulatory Authorities ◽  
Expanded Mesenchymal Stem Cells
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