scholarly journals MAGUK p55 Subfamily Member 3

2020 ◽  
Author(s):  
Keyword(s):  
Subfamily Member

scholarly journals Transcriptomic profile of Pea3 family members reveal regulatory codes for axon outgrowth and neuronal connection specificity

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Başak Kandemir ◽  
Gizem Gulfidan ◽  
Kazim Yalcin Arga ◽  
Bayram Yilmaz ◽  
Isil Aksan Kurnaz
Keyword(s):  
Transcription Factor ◽  
Target Genes ◽  
Neural Circuit ◽  
Molecular Model ◽  
Expression Profiles ◽  
Neuroblastoma Cells ◽  
Branching Morphogenesis ◽  
Subfamily Member ◽  
Circuit Formation ◽  
Cell Cell

Abstract PEA3 transcription factor subfamily is present in a variety of tissues with branching morphogenesis, and play a particularly significant role in neural circuit formation and specificity. Many target genes in axon guidance and cell–cell adhesion pathways have been identified for Pea3 transcription factor (but not for Erm or Er81); however it was not so far clear whether all Pea3 subfamily members regulate same target genes, or whether there are unique targets for each subfamily member that help explain the exclusivity and specificity of these proteins in neuronal circuit formation. In this study, using transcriptomics and qPCR analyses in SH-SY5Y neuroblastoma cells, hypothalamic and hippocampal cell line, we have identified cell type-specific and subfamily member-specific targets for PEA3 transcription factor subfamily. While Pea3 upregulates transcription of Sema3D and represses Sema5B, for example, Erm and Er81 upregulate Sema5A and Er81 regulates Unc5C and Sema4G while repressing EFNB3 in SH-SY5Y neuroblastoma cells. We furthermore present a molecular model of how unique sites within the ETS domain of each family member can help recognize specific target motifs. Such cell-context and member-specific combinatorial expression profiles help identify cell–cell and cell-extracellular matrix communication networks and how they establish specific connections.

A subset of Cd8+regulatory T cells interacts with an intestinal epithelial cell complex formed by Cd1d and a CEA subfamily member

2003 ◽  
Vol 124 (4) ◽  
pp. A83
Author(s):  
Matthieu Allez ◽  
Jens Brinnes ◽  
Ling Shao ◽  
Iris Dotan ◽  
Atsushi Nakazawa ◽  
...  
Keyword(s):  
T Cells ◽  
Epithelial Cell ◽  
Regulatory T Cells ◽  
Intestinal Epithelial Cell ◽  
Cell Complex ◽  
Intestinal Epithelial ◽  
Subfamily Member

Characterization of the GufA subfamily member SLC39A11/Zip11 as a zinc transporter

2013 ◽  
Vol 24 (10) ◽  
pp. 1697-1708 ◽  
Author(s):  
Yu Yu ◽  
Aimin Wu ◽  
Zhuzhen Zhang ◽  
Guang Yan ◽  
Fan Zhang ◽  
...  
Keyword(s):  
Zinc Transporter ◽  
Subfamily Member

scholarly journals DUB-1A, a Novel Deubiquitinating Enzyme Subfamily Member, Is Polyubiquitinated and Cytokine-inducible in B-lymphocytes

2003 ◽  
Vol 279 (4) ◽  
pp. 2368-2376 ◽  
Author(s):  
Kwang-Hyun Baek ◽  
Myung-Sun Kim ◽  
Yong-Soo Kim ◽  
Ju-Mi Shin ◽  
Hee-Kyung Choi
Keyword(s):  
B Lymphocytes ◽  
Deubiquitinating Enzyme ◽  
Subfamily Member

Characterization and expression of a new subfamily member of penaeidin antimicrobial peptides (penaeidin 5) from Fenneropenaeus chinensis

2007 ◽  
Vol 44 (7) ◽  
pp. 1535-1543 ◽  
Author(s):  
Cui-Jie Kang ◽  
Jian-Feng Xue ◽  
Ning Liu ◽  
Xiao-Fan Zhao ◽  
Jin-Xing Wang
Keyword(s):  
Antimicrobial Peptides ◽  
Fenneropenaeus Chinensis ◽  
Subfamily Member
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