Chief Cell of the Stomach

2020 ◽  
Author(s):  
Keyword(s):  
Chief Cell

Chief cell and clear cell parathyroid adenoma do not influence clinical and biochemical expression of the sporadic primary hyperparathyroidism

Endocrine ◽  
2012 ◽  
Vol 43 (2) ◽  
pp. 440-443 ◽  
Author(s):  
Shweta Varshney ◽  
Sanjay Kumar Bhadada ◽  
Uma Nahar ◽  
Viral N. Shah ◽  
Anil Bhansali ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Clear Cell ◽  
Chief Cell ◽  
Sporadic Primary Hyperparathyroidism

scholarly journals Chief cell plasticity is the origin of metaplasia following acute injury in the stomach mucosa

Gut ◽  
2021 ◽  
pp. gutjnl-2021-325310
Author(s):  
Brianna Caldwell ◽  
Anne R Meyer ◽  
Jared A Weis ◽  
Amy C Engevik ◽  
Eunyoung Choi
Keyword(s):  
Progenitor Cells ◽  
Mucosal Injury ◽  
Chief Cell ◽  
Lineage Tracing ◽  
Acute Injury ◽  
Specific Gene ◽  
Cell Plasticity ◽  
Chief Cells ◽  
Stomach Mucosa

ObjectiveMetaplasia arises from differentiated cell types in response to injury and is considered a precursor in many cancers. Heterogeneous cell lineages are present in the reparative metaplastic mucosa with response to injury, including foveolar cells, proliferating cells and spasmolytic polypeptide-expressing metaplasia (SPEM) cells, a key metaplastic cell population. Zymogen-secreting chief cells are long-lived cells in the stomach mucosa and have been considered the origin of SPEM cells; however, a conflicting paradigm has proposed isthmal progenitor cells as an origin for SPEM.DesignGastric intrinsic factor (GIF) is a stomach tissue-specific gene and exhibits protein expression unique to mature mouse chief cells. We generated a novel chief cell-specific driver mouse allele, GIF-rtTA. GIF-GFP reporter mice were used to validate specificity of GIF-rtTA driver in chief cells. GIF-Cre-RnTnG mice were used to perform lineage tracing during homoeostasis and acute metaplasia development. L635 treatment was used to induce acute mucosal injury and coimmunofluorescence staining was performed for various gastric lineage markers.ResultsWe demonstrated that mature chief cells, rather than isthmal progenitor cells, serve as the predominant origin of SPEM cells during the metaplastic process after acute mucosal injury. Furthermore, we observed long-term label-retaining chief cells at 1 year after the GFP labelling in chief cells. However, only a very small subset of the long-term label-retaining chief cells displayed the reprogramming ability in homoeostasis. In contrast, we identified chief cell-originating SPEM cells as contributing to lineages within foveolar cell hyperplasia in response to the acute mucosal injury.ConclusionOur study provides pivotal evidence for cell plasticity and lineage contributions from differentiated gastric chief cells during acute metaplasia development.

A Cytological and Cytochemical Study of the ‘Epithelial Body’ on the Carotid Artery of the Lizards, Trachysaurus Rugosus and Tiliqua Occipitalis

1963 ◽  
Vol s3-104 (66) ◽  
pp. 197-205
Author(s):  
D. C. ROGERS
Keyword(s):  
Epithelial Cell ◽  
Parathyroid Gland ◽  
Clear Cell ◽  
Cell Types ◽  
Chief Cell ◽  
Dark Cell ◽  
Secretory Cycle ◽  
Cytochemical Study ◽  
Cytochemical Investigation ◽  
The Subject

Epithelial body III of Tiliqua occipitalis and Trachysaurus rugosus has been the subject of a histological and cytochemical investigation with the object of making a comparison with the mammalian parathyroid gland. The cytochemical reactions of the reptilian chief cell are similar to those of the mammalian ‘pale principal’ cell. On the basis of a series of cytological and cytochemical changes a secretory cycle commencing with the chief cell and culminating in the water-clear cell is postulated. Two further cell types distinguished as the dark cell and the ‘epithelial’ cell have been described in the reptilian epithelial body. The significance of these two cell types is discussed. There is some evidence suggesting that true sinusoids invest the cellular cords. There is no evidence, with the technique used, that the gland cells are innervated. It is suggested that the general histology is comparable to that of the mammalian parathyroid gland.

Sign in / Sign up

Export Citation Format

Share Document