scholarly journals C4 Deficiency

2020 ◽  
Author(s):  
Keyword(s):  
C4 Deficiency

Systemic Lupus Erythematosus Suspected of C4 Deficiency due to Sustained Low Levels of C4

2013 ◽  
Vol 75 (3) ◽  
pp. 204-207
Author(s):  
Hiroaki HAYASHI ◽  
Eiichi MAKINO ◽  
Etsuko KITANO ◽  
Michiyo HATANAKA ◽  
Hajime KITAMURA ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
C4 Deficiency ◽  
Low Levels

HLA DRw8 and complement C4 deficiency as risk factors in primary biliary cirrhosis

1991 ◽  
Vol 101 (5) ◽  
pp. 1367-1373 ◽  
Author(s):  
Michael P. Manns ◽  
Andreas Bremm ◽  
Peter M. Schneider ◽  
Arman Notghi ◽  
Guido Gerken ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Complement C4 ◽  
C4 Deficiency

scholarly journals Genetically Determined Partial Complement C4 Deficiency States Are Not Independent Risk Factors for SLE in UK and Spanish Populations

2012 ◽  
Vol 90 (3) ◽  
pp. 445-456 ◽  
Author(s):  
Lora Boteva ◽  
David L. Morris ◽  
Josefina Cortés-Hernández ◽  
Javier Martin ◽  
Timothy J. Vyse ◽  
...  
Keyword(s):  
Risk Factors ◽  
Complement C4 ◽  
Spanish Populations ◽  
C4 Deficiency ◽  
Independent Risk Factors ◽  
Genetically Determined

HLA typing of cultured amniotic cells for the prenatal diagnosis of complement C4 deficiency and the identification of paternity

1980 ◽  
Vol 1 (3) ◽  
pp. 277-278
Author(s):  
M.S. Pollack ◽  
H. Ochs ◽  
I. Schafer ◽  
D. Barford ◽  
B. Dupont
Keyword(s):  
Prenatal Diagnosis ◽  
Hla Typing ◽  
Complement C4 ◽  
C4 Deficiency ◽  
Amniotic Cells

Clinical Manifestations in Humans of Combined C7 and C4 Deficiency Associated with Low Levels of C2, C8, and C9

1991 ◽  
Vol 8 (2) ◽  
pp. 70-79 ◽  
Author(s):  
Walter A. Wuillemin ◽  
Peter J. Späth ◽  
Béatrice Uring-Lambert ◽  
P. Werner Straub
Keyword(s):  
Clinical Manifestations ◽  
C4 Deficiency ◽  
Low Levels

Partial C4 deficiency in subacute sclerosing panencephalitis

1984 ◽  
Vol 20 (4) ◽  
pp. 407-415 ◽  
Author(s):  
Christian Rittner ◽  
Elke M. M. Meier ◽  
Beate Stradmann ◽  
Carolyn M. Giles ◽  
Rita K�chling ◽  
...  
Keyword(s):  
Subacute Sclerosing Panencephalitis ◽  
C4 Deficiency

scholarly journals Kidney transplantation in patients suffering from hereditary complete complement C4 deficiency

2007 ◽  
Vol 20 (12) ◽  
pp. 1044-1049 ◽  
Author(s):  
Christina Falkeis ◽  
Walter Mark ◽  
Consolato Sergi ◽  
Dorothea Heininger ◽  
Friedrich Neumair ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Complement C4 ◽  
C4 Deficiency

scholarly journals IN VITRO STUDIES OF COMPLEMENT FUNCTION IN SERA OF C4-DEFICIENT GUINEA PIGS

1971 ◽  
Vol 134 (1) ◽  
pp. 176-187 ◽  
Author(s):  
Michael M. Frank ◽  
Joseph May ◽  
Thelma Gaither ◽  
Leonard Ellman
Keyword(s):  
Guinea Pigs ◽  
In Vitro Studies ◽  
Complement C3 ◽  
Antigenic Analysis ◽  
Complement Components ◽  
Inflammatory Reactions ◽  
C4 Deficiency ◽  
Antigen Antibody

In vitro studies were performed utilizing sera from a strain of guinea pigs with a total absence of hemolytically active C4. Previous studies in these animals have demonstrated normal complement-dependent inflammatory reactions, suggesting that they are able to bypass their deficiency of C4. In vitro studies with C4-deficient serum also indicate normal activation of late-acting C components. Thus, endotoxin was capable of fixing normal amounts of the late components of complement (C3-9) in these sera, but did not fix C1 and C2. Antigen-antibody complexes fixed both early and late components of complement, although components beyond C4 were fixed less efficiently than in normal sera. Therefore, both in vivo and in vitro evidence indicates that the C4-deficient guinea pigs possess an alternate pathway for activation of late-acting complement components. Antigenic analysis of C4-deficient serum utilizing both guinea pig anti-C4 antibody and rabbit anti-C4 antibody suggests an absolute deficiency of C4-like molecules. Sera from animals with C4-deficiency were found to have one-half the normal level of C2. Sera from five of eight animals tested had 10–20% normal C1 activity. C3-9 assayed as a complex was normal.

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