scholarly journals Deoxygenated Hemoglobin

2020 ◽  
Author(s):  
Keyword(s):  
Deoxygenated Hemoglobin

Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin

NeuroImage ◽  
2005 ◽  
Vol 27 (4) ◽  
pp. 947-959 ◽  
Author(s):  
Joseph P. Culver ◽  
Andrew M. Siegel ◽  
Maria Angela Franceschini ◽  
Joseph B. Mandeville ◽  
David A. Boas
Keyword(s):  
Blood Volume ◽  
Spatial Resolution ◽  
Cerebral Blood Volume ◽  
Brain Activation ◽  
Deoxygenated Hemoglobin

Primary Role of Deoxygenated Hemoglobin in Erythrocytic Nitrite Reduction to NO

2013 ◽  
Vol 65 ◽  
pp. S101
Author(s):  
Chen Liu ◽  
Xiaohua Liu ◽  
John Janes ◽  
Swati Basu ◽  
Mark T. Gladwin ◽  
...  
Keyword(s):  
Nitrite Reduction ◽  
Primary Role ◽  
Deoxygenated Hemoglobin

Direct intracellular measurement of deoxygenated hemoglobin S solubility

Blood ◽  
2001 ◽  
Vol 98 (3) ◽  
pp. 883-884 ◽  
Author(s):  
Mary E. Fabry ◽  
Laurephile Desrosiers ◽  
Sandra M. Suzuka
Keyword(s):  
Transgenic Mouse ◽  
Hemoglobin Concentration ◽  
Red Cells ◽  
Red Cell ◽  
Hemoglobin S ◽  
Physiological Conditions ◽  
Polymer Formation ◽  
Solution Studies ◽  
Deoxygenated Hemoglobin

Abstract The solubility of deoxygenated hemoglobin S (HbS), which is the concentration of fully deoxygenated HbS in equilibrium with polymer (CSAT), is a factor that determines in vivo polymer formation. However, measurement of CSAT is usually performed under conditions that are far from physiological. In solution studies of HbS by Benesch et al, it was demonstrated that p50, the point at which hemoglobin is half-saturated with oxygen, is proportional to the amount of polymer formed and that it may be used to measure CSAT. This method has been extended to measure CSAT in intact red cells by varying extracellular osmolarity, which, in turn, varies intracellular hemoglobin concentration. This method measures intracellular CSAT under physiological conditions with intact red cell contents and can be applied to human and transgenic mouse red cells. The principle is demonstrated by measuring p50 as a function of extracellular osmolarity for AA, SS, and AS red cells.

scholarly journals Double filaments in fibers and crystals of deoxygenated hemoglobin S

1980 ◽  
Vol 32 (1) ◽  
pp. 436-438 ◽  
Author(s):  
Beatrice Magdoff-Fairchild ◽  
Celia C. Chiu
Keyword(s):  
Hemoglobin S ◽  
Deoxygenated Hemoglobin

scholarly journals Multi-Aspect Optoacoustic Imaging of Breast Tumors under Chemotherapy with Exogenous and Endogenous Contrasts: Focus on Apoptosis and Hypoxia

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1696
Author(s):  
Angelos Karlas ◽  
Antonio Nunes ◽  
Wouter Driessen ◽  
Evangelos Liapis ◽  
Josefine Reber
Keyword(s):  
Breast Cancer ◽  
Ex Vivo ◽  
Imaging Modality ◽  
Therapy Response ◽  
Breast Tumors ◽  
Chemotherapeutic Agents ◽  
Tumor Type ◽  
Optoacoustic Imaging ◽  
Deoxygenated Hemoglobin

Breast cancer is a complex tumor type involving many biological processes. Most chemotherapeutic agents exert their antitumoral effects by rapid induction of apoptosis. Another main feature of breast cancer is hypoxia, which may drive malignant progression and confer resistance to various forms of therapy. Thus, multi-aspect imaging of both tumor apoptosis and oxygenation in vivo would be of enormous value for the effective evaluation of therapy response. Herein, we demonstrate the capability of a hybrid imaging modality known as multispectral optoacoustic tomography (MSOT) to provide high-resolution, simultaneous imaging of tumor apoptosis and oxygenation, based on both the exogenous contrast of an apoptosis-targeting dye and the endogenous contrast of hemoglobin. MSOT imaging was applied on mice bearing orthotopic 4T1 breast tumors before and following treatment with doxorubicin. Apoptosis was monitored over time by imaging the distribution of xPLORE-APOFL750©, a highly sensitive poly-caspase binding apoptotic probe, within the tumors. Oxygenation was monitored by tracking the distribution of oxy- and deoxygenated hemoglobin within the same tumor areas. Doxorubicin treatment induced an increase in apoptosis-depending optoacoustic signal of xPLORE-APOFL750© at 24 h after treatment. Furthermore, our results showed spatial correspondence between xPLORE-APO750© and deoxygenated hemoglobin. In vivo apoptotic status of the tumor tissue was independently verified by ex vivo fluorescence analysis. Overall, our results provide a rationale for the use of MSOT as an effective tool for simultaneously investigating various aspects of tumor pathophysiology and potential effects of therapeutic regimes based on both endogenous and exogenous molecular contrasts.

MÖSSBAUER SPECTRA OF DEOXYGENATED HEMOGLOBIN IN R AND T STATES

1976 ◽  
Vol 37 (C6) ◽  
pp. C6-181-C6-183
Author(s):  
A. MERLI ◽  
I. ORTALLI ◽  
E. PAPOTTI ◽  
G. L. ROSSI
Keyword(s):  
Mössbauer Spectra ◽  
Mossbauer Spectra ◽  
Deoxygenated Hemoglobin

Association Between Deoxygenated Hemoglobin Breaking Point, Anaerobic Threshold, and Rowing Performance

2019 ◽  
Vol 14 (8) ◽  
pp. 1103-1109
Author(s):  
Tiago Turnes ◽  
Rafael Penteado dos Santos ◽  
Rafael Alves de Aguiar ◽  
Thiago Loch ◽  
Leonardo Trevisol Possamai ◽  
...  
Keyword(s):  
Heart Rate ◽  
Anaerobic Threshold ◽  
Power Output ◽  
Vastus Lateralis ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Breaking Point ◽  
Vastus Lateralis Muscle ◽  
Incremental Test ◽  
Deoxygenated Hemoglobin

Purpose: To compare the intensity and physiological responses of deoxygenated hemoglobin breaking point ([HHb]BP) and anaerobic threshold (AnT) during an incremental test and to verify their association with 2000-m rowing-ergometer performance in well-trained rowers. Methods: A total of 13 male rowers (mean [SD] age = 24 [11] y and  = 63.7 [6.1] mL·kg−1·min−1) performed a step incremental test. Gas exchange, vastus lateralis [HHb], and blood lactate concentration were measured. Power output, , and heart rate of [HHb]BP and AnT were determined and compared with each other. A 2000-m test was performed in another visit. Results: No differences were found between [HHb]BP and AnT in the power output (236 [31] vs 234 [31] W; Δ = 0.7%), 95% confidence interval [CI] 6.7%), (4.2 [0.5] vs 4.3 [0.4] L·min−1; Δ = −0.8%, 95% CI 4.0%), or heart rate (180 [16] vs 182 [12] beats·min−1; Δ = −1.6%, 95% CI 2.1%); however, there was high typical error of estimate (TEE) and wide 95% limits of agreement (LoA) for power output (TEE 10.7%, LoA 54.1–50.6 W), (TEE 5.9%, LoA −0.57 to 0.63 L·min−1), and heart rate (TEE 2.4%, LoA −9.6 to 14.7 beats·min−1). Significant correlations were observed between [HHb]BP (r = .70) and AnT (r = .89) with 2000-m mean power. Conclusions: These results demonstrate a breaking point in [HHb] of the vastus lateralis muscle during the incremental test that is capable of distinguishing rowers with different performance levels. However, the high random error would compromise the use of [HHb]BP for training and testing in rowing.

Sequential Pulse Compression’s Effect on Blood Flow in the Lower-Extremity

2020 ◽  
Vol 29 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Kelly A. Brock ◽  
Lindsey E. Eberman ◽  
Richard H. Laird ◽  
David J. Elmer ◽  
Kenneth E. Games
Keyword(s):  
Physical Activity ◽  
Blood Flow ◽  
Lower Extremity ◽  
Muscle Soreness ◽  
Pulse Compression ◽  
Hemoglobin Concentration ◽  
Medial Gastrocnemius ◽  
Medium Effect ◽  
Change Scores ◽  
Deoxygenated Hemoglobin

Context: Several interventions are available to reduce the intensity and duration of the unwanted effects (eg, muscle soreness) associated with physical activity, such as massage, compression garments, and sequential pulse compression (SPC). Such interventions aim to increase blood flow to alleviate symptoms. However, there is a lack of evidence to support the use of SPC to alter total hemoglobin concentration (THb) in active individuals. Objective: To examine the acute effects of a single session of SPC on hemoglobin concentration compared with a control condition. Design: Single cohort, crossover design. Participants: Thirty-four physically active and healthy participants (females = 12 and males = 22) completed the study. Interventions: The authors randomly assigned participants to first receive the experimental (SPC) or control condition. Measures were recorded precondition and postcondition. Participants returned to the laboratory to complete the second condition ≥24 hours after the first condition. Main Outcome Measures: Relative changes in THb, deoxygenated hemoglobin, and oxygenated hemoglobin measures were recorded using near-infrared spectroscopy placed on the muscle belly of the medial gastrocnemius of the dominant limb. Results: SPC significantly increased THb (P < .001, d = 0.505) and oxygenated hemoglobin (P < .001, d = 0.745) change scores compared with the control condition. No statistical difference in deoxygenated hemoglobin change scores was found between the SPC and control conditions, but a medium effect size suggests potential biological significance (P = .06, d = 0.339). Conclusions: Overall, SPC increases THb to the lower-extremity and may be a viable option in the management of muscle soreness related to physical activity.

scholarly journals Direct Calorimetric Studies on the Heats of Ionization of Oxygenated and Deoxygenated Hemoglobin

1967 ◽  
Vol 242 (5) ◽  
pp. 777-783
Author(s):  
J.R. Chipperfield ◽  
L. Rossi-Bernardi ◽  
F. J.W. Roughton
Keyword(s):  
Calorimetric Studies ◽  
Deoxygenated Hemoglobin

Elevating intracranial pressure reverses the decrease in deoxygenated hemoglobin and abolishes the post-stimulus overshoot upon somatosensory activation in rats

NeuroImage ◽  
2010 ◽  
Vol 52 (2) ◽  
pp. 445-454 ◽  
Author(s):  
Martina Füchtemeier ◽  
Christoph Leithner ◽  
Nikolas Offenhauser ◽  
Marco Foddis ◽  
Matthias Kohl-Bareis ◽  
...  
Keyword(s):  
Intracranial Pressure ◽  
Deoxygenated Hemoglobin
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