scholarly journals MUC1 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Muc1 Gene

Adenovirus-Mediated MUC1 Gene Transduction into Human Blood-Derived Dendritic Cells

2001 ◽  
Vol 24 (4) ◽  
pp. 345-353 ◽  
Author(s):  
Kouji Maruyama ◽  
Yasuto Akiyama ◽  
Noriko Nara-Ashizawa ◽  
Takashi Hojo ◽  
Jin-Yan Cheng ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Human Blood ◽  
Gene Transduction ◽  
Muc1 Gene

scholarly journals Identification of two novel elements involved in human MUC1 gene expression in vivo

2002 ◽  
Vol 8 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Toshiyuki Shiraga ◽  
David Smith ◽  
Hugh N. Nuthall ◽  
Michael A. Hollingsworth ◽  
Ann Harris
Keyword(s):  
Gene Expression ◽  
Muc1 Gene ◽  
Human Muc1

MUC1 gene polymorphism in three Nelore lines selected for growth and its association with growth and carcass traits

2011 ◽  
Vol 39 (2) ◽  
pp. 1541-1549 ◽  
Author(s):  
Fabio Ricardo Pablos de Souza ◽  
Sandra Maione ◽  
Stefano Sartore ◽  
Dominga Soglia ◽  
Veronica Spalenza ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Carcass Traits ◽  
Muc1 Gene

scholarly journals A Novel Protein Derived from the MUC1 Gene by Alternative Splicing and Frameshifting

2004 ◽  
Vol 280 (11) ◽  
pp. 10655-10663 ◽  
Author(s):  
Fiana Levitin ◽  
Amos Baruch ◽  
Mordechai Weiss ◽  
Keren Stiegman ◽  
Mor-li Hartmann ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Muc1 Gene ◽  
Novel Protein

scholarly journals Analysis of the Sheep MUC1 Gene: Structure of the Repetitive Region and Polymorphism

2007 ◽  
Vol 90 (2) ◽  
pp. 1024-1028 ◽  
Author(s):  
R. Rasero ◽  
L. Bianchi ◽  
E. Cauvin ◽  
S. Maione ◽  
S. Sartore ◽  
...  
Keyword(s):  
Gene Structure ◽  
Repetitive Region ◽  
Muc1 Gene

scholarly journals Immunohistochemical Detection of the MUC1 Gene Product in Human Cancers Grown in scid Mice

1998 ◽  
Vol 46 (1) ◽  
pp. 127-134 ◽  
Author(s):  
Udo Schumacher ◽  
Elizabeth Adam
Keyword(s):  
Gene Product ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Small Cell ◽  
Scid Mice ◽  
Breast Cancer Cell Lines ◽  
Primary Tumors ◽  
Muc1 Gene ◽  
Mucin Expression

Alterations in mucin expression have been detected in many clinically relevant cancers and, in particular, the polymorphic epithelial mucin, encoded by the MUC1 gene, has attracted considerable attention. We investigated its expression in human breast, colon, ovarian, lung, and skin cancer cells and their metastases grown in severe combined immunodeficient ( scid) mice using three different monoclonal antibodies (HMFG-1, HMFG-2, and SM3). Four of five breast cancer cell lines, three of five colon cancer cell lines, two of three small-cell carcinoma of the lung cell lines, and A 431 cells all expressed the MUC1 gene product. Neuraminidase predigestion often enhanced HMFG-1 immunoreactivity, which was more widespread and stronger than SM3 immunoreactivity. A considerable heterogeneity of MUC1 gene product expression was observed in the same tumors grown in different mice. The binding pattern between single-cell/small-cell clusters (up to 10 cells) and larger cell number aggregates varied. The results indicate that the MUC1 gene expression both in primary tumors and metastases is not tightly controlled within a particular tumor cell line. Because of this heterogeneous antigen expression in vivo, it appears impossible to target all metastatic deposits by a single monoclonal antibody directed against the MUC1 gene product.

scholarly journals MUC1 gene silencing inhibits proliferation, invasion, and migration while promoting apoptosis of oral squamous cell carcinoma cells

2019 ◽  
Vol 39 (9) ◽  
Author(s):  
Ai-Min Zhang ◽  
Xiao-Hui Chi ◽  
Zu-Qiang Bo ◽  
Xiao-Fang Huang ◽  
Jin Zhang
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Gene Silencing ◽  
Invasion And Migration ◽  
Normal Oral Mucosa ◽  
Muc1 Gene ◽  
Slug Expression ◽  
And Migration

Abstract The aim of the present study is to investigate the role of RNA interference in the inhibition of MUC1 gene expression in occurrence and metastasis of oral squamous cell carcinoma (OSCC) and its in-depth mechanisms. The OSCC and normal oral mucosa tissues, as well as normal oral epithelial cell line HOK and OSCC cell line SCC-4, Cal-27, TSCCA, Tca8113 were obtained to detect the expression of MUC1. Slug expression in OSCC and normal oral mucosa tissues was also determined. The OSCC cells were grouped to investigate the role of MUC1 gene silencing on proliferation, DNA replication, cell cycle distribution, apoptosis, colony formation ability, epithelial-mesenchymal transition (EMT), invasion, and migration of OSCC cells. We first found higher positive rate of MUC1 and Slug expression in OSCC tissues. Next, it was determined that higher expression of MUC1 was found in OSCC tissues and cells. Furthermore, silencing of MUC1 declined Slug expression, inhibited the proliferation, DNA replication, cell cycle progression, and EMT while inducing apoptosis of OSCC cells. Our study suggests that overexpression of MUC1 is found in OSCC, and MUC1 gene silencing could inhibit the proliferation, invasion, and migration while inducing apoptosis of OSCC cells.

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