scholarly journals Benign Teratoma

2020 ◽  
Author(s):  
Keyword(s):  
1990 ◽  
Vol 8 (1) ◽  
pp. 27-32 ◽  
Author(s):  
J A Levi ◽  
D Thomson ◽  
V Harvey ◽  
G Gill ◽  
D Raghavan ◽  
...  

Fifty-one patients with advanced germ cell malignancy who had either failed to achieve complete remission with initial cisplatin, vinblastine, and bleomycin chemotherapy or who had relapsed after complete response (CR) to this therapy and then proven refractory on retreatment, were treated with etoposide (75 mg/m2 for 3 days), dactinomycin (1 mg/m2 day 1), and methotrexate (30 mg/m2 day 1) (EAM) every 3 weeks. Courses were continued until maximum response without empirical limit, and if complete remission was achieved, two courses of consolidation therapy were given before cessation of treatment. Thirteen patients (25%) were complete responders with residual masses containing fibrosis or benign teratoma being subsequently resected in seven patients. Two patients had persisting viable carcinoma within residual masses that were completely resected, leaving no evidence of disease (NED); the combined CR plus NED rate was 29%. The only pretreatment factor significantly influencing this response rate was tumor volume. Toxicities were moderate, with leukopenia being observed in 28% of patients, but it was severe in only 2%. There was one death from septicemia. Severe nausea and vomiting occurred in only 9% of patients and treatment-related stomatitis was observed in 42%. All patients achieving CR plus NED have been followed for a minimum of 5 years and no relapses have occurred, suggesting that these patients are cured. Unlike other regimens of salvage chemotherapy, this treatment program did not contain cisplatin and it is contended that a completely noncrossresistant drug regimen based on etoposide provides the opportunity to further improve the curability of patients with advanced germ cell cancer.


1998 ◽  
Vol 81 (5) ◽  
pp. 760-761 ◽  
Author(s):  
Defabiani ◽  
Iselin ◽  
Khan ◽  
Pache ◽  
Rohner
Keyword(s):  

2009 ◽  
Vol 5 (1) ◽  
pp. 72-74 ◽  
Author(s):  
Michelle E. Koski ◽  
John C. Thomas
Keyword(s):  

1969 ◽  
Vol 7 (1) ◽  
pp. 38-41 ◽  
Author(s):  
William C. Wilhelm ◽  
E. Buist Wells ◽  
George J. D'Angelo

2013 ◽  
Vol 1 (6) ◽  
pp. 202 ◽  
Author(s):  
Mehdi Alimehmeti
Keyword(s):  

Author(s):  
Mohammed Humaam Ansari ◽  
Atishkumar Balajirao Gujrathi ◽  
Vijayalaxmi Ambulgekar

<p>Cervical teratomas are extremely rare germ cell tumours. Cervical teratoma is much more common in newborn than adults, and in contrast to the paediatric cases adult teratomas have been highly malignant. Cervical teratoma incorporates lesions arising in the anterior and posterior triangles of the neck. Cervical teratoma can reach enormous size and cause airway obstruction.  Surgery is the primary modality of treatment as malignant transformation occurs. Hereby, we present a case of benign teratoma of neck in adult which was completely misdiagnosed preoperatively due to its rare occurence in adults. Even though cervical teratoma of adult is extremely rare, it should be considered as an important differential diagnosis in patient of midline cystic neck swelling. Preoperative radiological investigations requires high index of suspicion. Complete surgical resection is recommended. </p>


Videoscopy ◽  
2016 ◽  
Vol 26 (6) ◽  
Author(s):  
Arul Thirumoorthi ◽  
Howard Kao ◽  
Joanne Baerg

2006 ◽  
Vol 16 (1) ◽  
pp. 76-77 ◽  
Author(s):  
Bart Meuris ◽  
Marc Gewillig ◽  
Bart Meyns

We report a neonate presenting with an intrapericardial benign teratoma and an exceptionally high level of alpha-fetoprotein. Such severe elevation of alpha-fetoprotein in a neonate with a teratoma is usually associated with the presence of immature or malignant elements, compromising the prognosis. The tumour in our patient, however, proved to be completely benign. We discuss recent findings with regard to normal levels of alpha-fetoprotein levels in preterm infants, and in children with neonatal teratomas.


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