Quinapril Hydrochloride

2020 ◽  
Author(s):  
Keyword(s):  
Quinapril Hydrochloride

Application of Ugi three component reaction for the synthesis of quinapril hydrochloride

2019 ◽  
Vol 50 (1) ◽  
pp. 48-55
Author(s):  
Bhushan B. Borase ◽  
Himanshu M. Godbole ◽  
Girij P. Singh ◽  
Pritesh R. Upadhyay ◽  
Anurag Trivedi ◽  
...  
Keyword(s):  
Three Component Reaction ◽  
Quinapril Hydrochloride

Quinapril hydrochloride effects on renal function in patients with renal dysfunction and hypertension: A drug-withdrawal study

1994 ◽  
Vol 8 (2) ◽  
pp. 271-275 ◽  
Author(s):  
Mary Alice Miller ◽  
Michele Texter ◽  
Anita Gmerek ◽  
Jeffery Robbins ◽  
Linda Shurzinske ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Dysfunction ◽  
Drug Withdrawal ◽  
Quinapril Hydrochloride

scholarly journals STUDY OF DIRECT COMPRESSION METHOD FOR THE PREPARATION OF QUINAPRIL HYDROCHLORIDE TABLETS

2019 ◽  
pp. 202-211
Author(s):  
SHWETHA MARGRET JL ◽  
MADHAVI BLR
Keyword(s):  
Batch Size ◽  
In Vitro Dissolution ◽  
Content Uniformity ◽  
Compatibility Study ◽  
Direct Compression ◽  
Compression Method ◽  
Compression Technique ◽  
Blend Uniformity ◽  
Excipient Compatibility ◽  
Quinapril Hydrochloride

Objective: Direct compression method is preferable for tablet manufacture. The direct compression method is followed for many formulations but the relevant study is not reported. The present work aims to study the suitability of the direct compression process to prepare tablets of quinapril hydrochloride (QHCl), a low dose drug with a starting dose of 5 mg, indicated in the treatment of hypertension, congestive heart failure, and other conditions. Methods: QHCl is reported to be unstable in the presence of moisture, heat, and some excipients. The direct compression method was tried instead of a wet granulation technique to prepare the tablets. Initially, drug-excipient compatibility study was carried out. For selected excipients and QHCl preformulation tests were conducted. The stabilizer was employed. Three formulations were tried. The blends were prepared by tumbling and trituration methods. Blend uniformity and precompression parameters were determined. Tablets were directly compressed and evaluated. Results: Drug-excipient compatibility was studied at 60°C and 40°C with an Relative humidity (RH) of 75% for 4 weeks. It showed discoloration of the pure drug and most of the drug excipient mixtures. Three formulations Q1, Q2, and Q3 were prepared using magnesium oxide (light), magnesium carbonate (light), and Aerosil as stabilizers. Blending was done by trituration and tumbling method for 10 min and 15 min duration for the given batch size. Blend uniformity was determined. Tumbling method for 15 min showed good blending as evident from the percentage coefficient of variation values. The blends had a good flow. Tablet evaluation showed hardness in the range of 2.5–3 kg/cm2 and disintegration time of 1–2 min. Q1 and Q2 passed the friability test. The content uniformity criterion was achieved with an acceptance value <20. In vitro dissolution, Q1 and Q2 were 100% and 98.8%, respectively, in 30 min and followed first-order kinetics. The stability study of Q1 indicated a single peak in the chromatogram corresponding to the drug. Q2 showed spotted discoloration. Conclusion: The direct compression technique could be employed for the preparation of QHCl tablets. Q1 showed better stability and release characteristics. Q2 and Q3 are considered for further study.

scholarly journals Simultaneous Estimation of Quinapril Hydrochloride and Hydrochlorothiazide from Pharmaceutical Formulation by Using UV, IR and RP-HPLC

2014 ◽  
Vol 26 (13) ◽  
pp. 3799-3804 ◽  
Author(s):  
Vandana Tukaram Gawande ◽  
Pankaj Birajlal Miniyar ◽  
Deepali Dattatray Bhandari ◽  
Manasi Kailas Ghag ◽  
Dhananjaysingh Bhikamsingh Rajput ◽  
...  
Keyword(s):  
Pharmaceutical Formulation ◽  
Simultaneous Estimation ◽  
Rp Hplc ◽  
Quinapril Hydrochloride

Effects of Quinapril Hydrochloride in Patients with Essential Hypertension and Impaired Renal Function

1997 ◽  
Vol 19 (4) ◽  
pp. 495-502 ◽  
Author(s):  
Akira Owada ◽  
Hiroshi Nonoguchi ◽  
Yoshio Terada ◽  
Fumiaki Marumo ◽  
Kimio Tomita
Keyword(s):  
Renal Function ◽  
Essential Hypertension ◽  
Impaired Renal Function ◽  
Quinapril Hydrochloride
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