FABP2 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Fabp2 Gene

scholarly journals Postprandial Hypertriglyceridemia Is Associated with the Variant 54 Threonine FABP2 Gene

2018 ◽  
Vol 5 (3) ◽  
pp. 47 ◽  
Author(s):  
María Garcés Da Silva ◽  
Yamil Guarin ◽  
Yenny Carrero ◽  
Hilda Stekman ◽  
María Núñez Bello ◽  
...  
Keyword(s):  
Intracellular Transport ◽  
Hdl Cholesterol ◽  
Control Group ◽  
Normal Body Mass Index ◽  
Cvd Risk ◽  
Fatty Acid Binding ◽  
Plasma Triglycerides ◽  
Postprandial Hypertriglyceridemia ◽  
Fabp2 Gene ◽  
Apparently Healthy

Purpose: Fasting or postprandial hypertriglyceridemia is considered an independent cardiovascular disease (CVD) risk factor. The intestinal fatty acid binding protein (FABP2) is involved in the intracellular transport and metabolism of fatty acids. The presence of the Ala54Thr polymorphism of the FABP2 gene appears to be involved in postprandial hypertriglyceridemia. We explored the possible association of the Ala54Thr polymorphism with fat intolerance in apparently healthy, fasting, normolipidemic subjects with normal body-mass index and without diabetes. Methodology: A total of 158 apparently healthy individuals were classified as fat tolerant (n = 123) or intolerant (n = 35) according to their response (plasma triglycerides) to an oral abbreviated tolerance test with blood samples taken at 0, 2 and 4 h. At 0 h, all subjects ingested 26.3 g of fats. Presence of the Ala54Thr polymorphism of the FABP2 gene was evaluated by polymerase chain reaction–restriction fragment length (PCR–RFLP). Results: The group with fat intolerance (postprandial hypertriglyceridemia group) showed an increased frequency of the Thr54Thr genotype when compared with the group with normal fat tolerance (control group) (23% vs. 4%, respectively, OR: 16.53, 95% CI: 4.09–66.82, p: 0.0001, pc: 0.0003). Carriers of at least one Thr54 allele were up to six times more prevalent in the fat intolerant group than in the non-carriers. (OR: 6.35; 95% CI: 1.86–21.59, p: 0.0003, pc: 0.0009). The levels of plasma triglycerides (Tg) at 4 h after the test meal were higher in carriers of at least one 54Thr allele than in carriers of the Ala54 allele (p < 0.05). Conclusions: There is a significant association between postprandial hypertriglyceridemia and the presence of at least one 54Thr allele of the FABP2 gene. In addition, subjects with this genotype showed an increased ratio of Tg/HDL-cholesterol. This parameter is a marker of increased CVD risk and insulin resistance.

scholarly journals No Association found between the Ala54Thr Polymorphism of FABP2 Gene and Obesity and Obesity with Dyslipidemia in Japanese Schoolchildren

2001 ◽  
Vol 8 (3) ◽  
pp. 80-83 ◽  
Author(s):  
Kazue Endo ◽  
Hisako Yanagi ◽  
Chiaki Hirano ◽  
Yoshika Hayakawa ◽  
Hideo Hamaguchi ◽  
...  
Keyword(s):  
Fabp2 Gene

Association of the T54 allele of the FABP2 gene with cardiovascular risk factors in obese Mexican subjects

2007 ◽  
Vol 4 (3) ◽  
pp. 235-236 ◽  
Author(s):  
Erika Martínez-López ◽  
Bertha Ruíz-Madrigal ◽  
Iván Hernández-Cañaveral ◽  
Arturo Panduro
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Fabp2 Gene

The polymorphism Thr54 of the fabp2 gene slows down the onset of alcoholic cirrhosis in a Mexican population

2002 ◽  
Vol 36 ◽  
pp. 212-213
Author(s):  
Mario Salguero ◽  
Ricardo Leon ◽  
Jorge Segura ◽  
Rogelio Troyo ◽  
Daniel Quezada ◽  
...  
Keyword(s):  
Alcoholic Cirrhosis ◽  
Mexican Population ◽  
Fabp2 Gene

scholarly journals The Role Of rs1799883 Polymorphism Of The FABP2 Gene In The Pathogenesis Of Nosological Syntropy Of Gallstone Disease And Metabolic Syndrome

2021 ◽  
Vol 03 (06) ◽  
pp. 46-51
Author(s):  
Raximov Anvar Pulatboevich ◽  
◽  
Ismailov O’ktam Safaevich ◽  
Batirov Davronbek Yusupovich ◽  
◽  
...  
Keyword(s):  
Gallstone Disease ◽  
Molecular Genetic ◽  
Case Control ◽  
Control Model ◽  
Molecular Medicine ◽  
Genetic Studies ◽  
Homozygous Genotype ◽  
Risk Of Disease ◽  
Fabp2 Gene

Objective: to study the role of the rs1799883 polymorphism of the FABP2 gene in the pathogenesis of gallstone disease in combination with MS. Material and methods. Molecular genetic studies were carried out in the Department of Molecular Medicine and Cell Technologies of the RSNPMC Hematology. The analysis of the associations of the rs1799883 polymorphisms of the FABP2 gene was carried out using a case-control model. The main group consisted of 118 patients with cholelithiasis in combination with MS living in the Khorezm region. Results: As a result of our research, we identified a significant association of the homozygous genotype for the Thr allele with the development of gallstone disease in combination with MS. The indicator of the ratio of the chances of developing gallstone disease in combination with MS in carriers of this genotype was OR = 2.9 at 95% CI: 1.122- 7.424. The relative risk of disease was RR = 2.5 with 95% CI: 1.11-5.76. Conclusion: Our results allow us to conclude that the homozygous Thr/Thr genotype plays an important role in the formation of gallstone disease and obesity in people of Uzbek nationality.

Search for SNPs in the FABP2 gene using sequencing in gene pool chicken breeds

2020 ◽  
Vol 22 (5) ◽  
pp. 32-34
Author(s):  
T.A. Larkina ◽  
◽  
A.A. Krutikova ◽  
G.K. Peglivanyan ◽  
N.V. Dementieva ◽  
...  
Keyword(s):  
Gene Pool ◽  
Chicken Breeds ◽  
Fabp2 Gene

Epistatic effect between ACACA and FABP2 gene on abdominal fat traits in broilers

2010 ◽  
Vol 37 (8) ◽  
pp. 505-512 ◽  
Author(s):  
Guo Hu ◽  
Shouzhi Wang ◽  
Jianwei Tian ◽  
Lili Chu ◽  
Hui Li
Keyword(s):  
Epistatic Effect ◽  
Abdominal Fat ◽  
Fabp2 Gene

The FABP2 gene polymorphism in cerebrovascular disease

2004 ◽  
Vol 110 (6) ◽  
pp. 355-360 ◽  
Author(s):  
P. Wanby ◽  
P. Palmquist ◽  
I. Ryden ◽  
L. Brattstrom ◽  
M. Carlsson
Keyword(s):  
Gene Polymorphism ◽  
Cerebrovascular Disease ◽  
Fabp2 Gene

scholarly journals Polymorphism of the FABP2 gene: a population frequency analysis and an association study with cardiovascular risk markers in Argentina

2007 ◽  
Vol 8 (1) ◽  
Author(s):  
Laura C Gomez ◽  
Sebastián M Real ◽  
Marta S Ojeda ◽  
Sergio Gimenez ◽  
Luis S Mayorga ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Association Study ◽  
Frequency Analysis ◽  
Risk Markers ◽  
Population Frequency ◽  
Fabp2 Gene

Association of rs1799883 polymorphism of the FABP2 gene with various disorders of carbohydrate metabolism in residents of the Republic of Tatarstan

2018 ◽  
pp. 116-120
Author(s):  
F.V. Valeeva ◽  
К.B. Khasanova ◽  
Е.V. Valeeva ◽  
Т.А. Kiseleva ◽  
Е.А. Sozinova ◽  
...  
Keyword(s):  
Carbohydrate Metabolism ◽  
Fabp2 Gene ◽  
The Republic
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