scholarly journals CCR2 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Ccr2 Gene

MCP-1 and CCR2 gene polymorphisms in Czech patients with allergic disorders

2009 ◽  
Vol 36 (1) ◽  
pp. 69-72 ◽  
Author(s):  
L. Izakovicova Holla ◽  
F. Mrazek ◽  
M. Petrek
Keyword(s):  
Gene Polymorphisms ◽  
Ccr2 Gene ◽  
Allergic Disorders

Epigenetic modulation at the CCR2 gene correlates with the maintenance of behavioral sensitization to methamphetamine

2010 ◽  
Vol 15 (3) ◽  
pp. 358-361 ◽  
Author(s):  
Daigo Ikegami ◽  
Minoru Narita ◽  
Satoshi Imai ◽  
Kazuhiko Miyashita ◽  
Rie Tamura ◽  
...  
Keyword(s):  
Behavioral Sensitization ◽  
Ccr2 Gene ◽  
Epigenetic Modulation

The Role of the CCR2 Gene Polymorphism in Abdominal Aortic Aneurysms

Angiology ◽  
2011 ◽  
Vol 62 (2) ◽  
pp. 140-143 ◽  
Author(s):  
Nurkay Katrancioglu ◽  
Sinasi Manduz ◽  
Oguz Karahan ◽  
Mehmet Birhan Yilmaz ◽  
Ilhan Sezgin ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Abdominal Aortic ◽  
Ccr2 Gene

scholarly journals Chemokine Coreceptor-2 Gene Polymorphisms among HIV-1 Infected Individuals in Kenya

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Dorcas Wachira ◽  
Raphael Lihana ◽  
Vincent Okoth ◽  
Alex Maiyo ◽  
Samoel Ashimosi Khamadi
Keyword(s):  
Disease Progression ◽  
Gene Polymorphisms ◽  
Gene Mutations ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Ccr2 Gene ◽  
The Status ◽  
Host Genetic ◽  
Type V ◽  
Hiv 1

Chemokine Coreceptor-2 (CCR2) is an entry coreceptor for HIV-1. A mutation in the coding gene for this coreceptor, CCR2-64I, has been shown to be an important factor for delaying disease progression. In Kenya no studies have been done to determine the status of CCR2 gene polymorphisms among HIV-1 infected individuals. To determine the existence and distribution of CCR2 gene mutations and identify polymorphic groups of the coreceptor gene in the population, a cross-sectional study was conducted to analyze the differences in allelic frequencies of CCR2-64I among HIV-1 seropositive individuals. Blood samples were collected from HIV/AIDS screening centers and analyzed for the presence of CCR2-64I using restriction fragment length polymorphism (RFLP). One hundred and eighteen samples collected from different regions of the country were genotyped for the CCR2-64I mutation. Of these, 4 (3.4%) were homozygous mutants (I/I) and 21 (17.8%) were heterozygous (V/I). Ninety-three subjects (78.8%) were wild type (V/V). With the search for a preventive/therapeutic HIV vaccine elusive, the presence of CCR-2 gene polymorphisms that delay disease progression and prolong the lives of the infected in the Kenyan population may contribute to the growing evidence that host genetic factors are important in predicting susceptibility to HIV-1 infection.

scholarly journals Identification of myeloid cells in the human enthesis as the main source of local IL-23 production

2019 ◽  
Vol 78 (7) ◽  
pp. 929-933 ◽  
Author(s):  
Charlie Bridgewood ◽  
Abdulla Watad ◽  
Tobias Russell ◽  
Timothy M Palmer ◽  
Helena Marzo-Ortega ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Cell Population ◽  
Expression Profile ◽  
Myeloid Cells ◽  
Myeloid Cell ◽  
Ccr2 Gene ◽  
Similar Gene Expression Profile ◽  
Normal Human ◽  
Similar Gene

ObjectiveWe investigated whether the normal human spinal enthesis contained resident myeloid cell populations, capable of producing pivotal proinflammatory cytokines including tumour necrosis factor (TNF) and interleukin (IL)-23 and determined whether these could be modified by PDE4 inhibition.MethodsNormal human enthesis soft tissue (ST) and adjacent perientheseal bone (PEB) (n=15) were evaluated using immunohistochemistry (IHC), digested for myeloid cell phenotyping, sorted and stimulated with different adjuvants (lipopolysaccharide and mannan). Stimulated enthesis fractions were analysed for inducible production of spondyloarthropathy disease-relevant mediators (IL-23 full protein, TNF, IL-1β and CCL20). Myeloid populations were also compared with matched blood populations for further mRNA analysis and the effect of PDE4 inhibition was assessed.ResultsA myeloid cell population (CD45+ HLADR+ CD14+ CD11c+) phenotype was isolated from both the ST and adjacent PEB and termed ‘CD14+ myeloid cells’ with tissue localisation confirmed by CD14+ IHC. The CD14− fraction contained a CD123+ HLADR+ CD11c− cell population (plasmacytoid dendritic cells). The CD14+ population was the dominant entheseal producer of IL-23, IL-1β, TNF and CCL20. IL-23 and TNF from the CD14+ population could be downregulated by a PDE4I and other agents (histamine and 8-Bromo-cAMP) which elevate cAMP. Entheseal CD14+ cells had a broadly similar gene expression profile to the corresponding CD14+ population from matched blood but showed significantly lower CCR2 gene expression.ConclusionsThe human enthesis contains a CD14+ myeloid population that produces most of the inducible IL-23, IL-1β, TNF and CCL20. This population has similar gene expression profile to the matched blood CD14+ population.

scholarly journals POLYMORPHISM THE CCR2 GENE IN THE ST. PETERSBURG POPULATION

2019 ◽  
Vol 8 (4) ◽  
pp. 591
Author(s):  
N. E. Lyubimova ◽  
A. V. Semenov
Keyword(s):  
Ccr2 Gene

.

scholarly journals CCR2 Gene Deletion and Pharmacologic Blockade Ameliorate a Severe Murine Experimental Autoimmune Neuritis Model of Guillain-Barré Syndrome

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e90463 ◽  
Author(s):  
Furong Yuan ◽  
Nejla Yosef ◽  
Chetan Lakshmana Reddy ◽  
Ailing Huang ◽  
Sharon C. Chiang ◽  
...  
Keyword(s):  
Gene Deletion ◽  
Guillain Barre Syndrome ◽  
Experimental Autoimmune Neuritis ◽  
Ccr2 Gene ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Experimental Autoimmune
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