scholarly journals A Randomised, Crossover, Clinical Study to Assess Nicotine Pharmacokinetics and Subjective Effects of the BIDI® Stick ENDS Compared with Combustible Cigarettes and a Comparator ENDS in Adult Smokers

2021 ◽  
Author(s):  
Ian Fearon ◽  
Karin Gilligan ◽  
Ryan Seltzer ◽  
Willie McKinney
Keyword(s):  
Clinical Study ◽  
Subjective Effects ◽  
Nicotine Pharmacokinetics

scholarly journals A Randomised, Crossover, Clinical Study to Assess Nicotine Pharmacokinetics and Subjective Effects of the BIDI Stick ENDS Compared with Combustible Cigarettes and a Comparator ENDS in Adult Smokers

2021 ◽  
Author(s):  
Ian M. Fearon ◽  
Karin Gilligan ◽  
Ryan G.N. Seltzer ◽  
Willie McKinney
Keyword(s):  
Clinical Study ◽  
Cigarette Smoking ◽  
Subjective Effects ◽  
Delivery Systems ◽  
Trial Registration ◽  
Blood Samples ◽  
Electronic Nicotine Delivery Systems ◽  
Time Points ◽  
Nicotine Pharmacokinetics ◽  
Ad Libitum

Abstract Background: Nicotine pharmacokinetic assessments of electronic nicotine delivery systems (ENDS) are crucial to understand their ability to provide an alternative to cigarette smoking. Subjective effects data also strongly contribute to this understanding. The BIDI® Stick is a disposable ENDS product which contains 6% nicotine benzoate salt and various flavours. Methods: In this study we assessed nicotine pharmacokinetic and subjective effects of BIDI® Stick ENDS in adult smokers, compared to cigarettes and a comparator ENDS product. During each of eight (8) study visits, volunteer smoker subjects randomly used one of either their usual brand (UB) of cigarette, a BIDI® Stick ENDS, or a comparator ENDS (JUUL 5% with Virginia Tobacco flavour), during both defined (10 puffs, 30 seconds apart) and ad libitum puffing sessions. Blood samples were collected at various time points and subjective effects questionnaires were administered. Results: Plasma nicotine Cmax 0-120 was not significantly different between BIDI® Stick ENDS with any flavour (range 15.3 (9.90) ng/ml for BIDI® Stick Winter to 17.6 (9.00) ng/ml for BIDI® Stick Classic) and UB cigarettes [16.2 (9.17) ng/ml]. AUC0-120 and Tmax 0-120 values were also not significantly different between BIDI® Stick ENDS and UB cigarettes, while subjective effects measures were also similar between BIDI® Stick ENDS and UB cigarettes. Conclusions: BIDI® Stick ENDS delivered nicotine to users comparably to their UB combustible cigarette and also elicited similar subjective effects such as satisfaction and relief. Thus, the BIDI® Stick ENDS may be a satisfying alternative to cigarettes among current smokers and may support their transitioning away from cigarette smoking. Trial registration: ClinicalTrials.gov (identifier number NCT05072925).

scholarly journals Nicotine pharmacokinetics and subjective effects of three potential reduced exposure products, moist snuff and nicotine lozenge

2007 ◽  
Vol 16 (2) ◽  
pp. 138-142 ◽  
Author(s):  
M. Kotlyar ◽  
M I. Mendoza-Baumgart ◽  
Z.-z. Li ◽  
P. R Pentel ◽  
B. C Barnett ◽  
...  
Keyword(s):  
Subjective Effects ◽  
Nicotine Pharmacokinetics ◽  
Moist Snuff ◽  
Nicotine Lozenge

scholarly journals Evaluation of Nicotine Pharmacokinetics and Subjective Effects following Use of a Novel Nicotine Delivery System

2017 ◽  
Vol 20 (4) ◽  
pp. 458-465 ◽  
Author(s):  
Axel Teichert ◽  
Patrick Brossard ◽  
Loyse Felber Medlin ◽  
Larissa Sandalic ◽  
Mikael Franzon ◽  
...  
Keyword(s):  
Delivery System ◽  
Subjective Effects ◽  
Nicotine Delivery ◽  
Nicotine Pharmacokinetics

A Clinical Study of Twenty-seven Children Exhibiting Functional Hearing Loss

1981 ◽  
Vol 12 (1) ◽  
pp. 26-35 ◽  
Author(s):  
Donald L. McCanna ◽  
Giacinto DeLapa
Keyword(s):  
Hearing Loss ◽  
Clinical Study ◽  
Early Identification ◽  
Behavioral Responses ◽  
Upper Elementary ◽  
Elementary Grades ◽  
Ability Level ◽  
Hearing Problem

This report reviews 27 cases of children exhibiting functional hearing loss. The study reveals that most students were in the upper elementary grades and were predominantly females. These subjects were functioning below their ability level in school and were usually in conflict with school, home, or peers. Tests used were selected on the basis of their helping to provide early identification. The subjects' oral and behavioral responses are presented, as well as ways of resolving the hearing problem. Some helpful counseling techniques are also presented.

Entergastrone Parenterally in the Treatment of Peptic Ulcer: A Controlled Clinical Study

1951 ◽  
Vol 17 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Frank C. Bone ◽  
Chester Cassel ◽  
Julian M. Ruffin ◽  
Robert J. Reeves
Keyword(s):  
Peptic Ulcer ◽  
Clinical Study ◽  
Controlled Clinical Study

Clinical Study of Five-Year Survivors After Surgery for Gastric Carcinoma

1961 ◽  
Vol 40 (2) ◽  
pp. 188-196 ◽  
Author(s):  
Charles H. Brown ◽  
Mauro Merlo ◽  
John B. Hazard
Keyword(s):  
Clinical Study ◽  
Gastric Carcinoma

589: Tissue Engineered Tubularized Urethra for Surgical Reconstruction: A Pre-Clinical Study

2007 ◽  
Vol 177 (4S) ◽  
pp. 197-197 ◽  
Author(s):  
Hazem O. Orabi ◽  
Tamer A. Aboushwareb ◽  
Yuan Yuan Zhang ◽  
James J. Yoo ◽  
Anthony Atala
Keyword(s):  
Clinical Study ◽  
Surgical Reconstruction
Sign in / Sign up

Export Citation Format

Share Document