Protein Acetylation

2020 ◽  
Author(s):  
Keyword(s):  
Protein Acetylation

Protein acetylation: a novel modus of obesity regulation

2021 ◽  
Author(s):  
Yuexia Liu ◽  
Hong Yang ◽  
Xuanchen Liu ◽  
Huihui Gu ◽  
Yizhou Li ◽  
...  
Keyword(s):  
Protein Acetylation

scholarly journals Protein Acetylation at the Interface of Genetics, Epigenetics and Environment in Cancer

Metabolites ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 216
Author(s):  
Mio Harachi ◽  
Kenta Masui ◽  
Webster K. Cavenee ◽  
Paul S. Mischel ◽  
Noriyuki Shibata
Keyword(s):  
Cancer Cells ◽  
Intracellular Signaling ◽  
Cancer Biology ◽  
High Resolution Mass Spectrometry ◽  
Metabolic Reprogramming ◽  
Protein Acetylation ◽  
Protein Activity ◽  
Oncogenic Signaling ◽  
Intermediary Metabolites ◽  
Novel Therapeutic Strategies

Metabolic reprogramming is an emerging hallmark of cancer and is driven by abnormalities of oncogenes and tumor suppressors. Accelerated metabolism causes cancer cell aggression through the dysregulation of rate-limiting metabolic enzymes as well as by facilitating the production of intermediary metabolites. However, the mechanisms by which a shift in the metabolic landscape reshapes the intracellular signaling to promote the survival of cancer cells remain to be clarified. Recent high-resolution mass spectrometry-based proteomic analyses have spotlighted that, unexpectedly, lysine residues of numerous cytosolic as well as nuclear proteins are acetylated and that this modification modulates protein activity, sublocalization and stability, with profound impact on cellular function. More importantly, cancer cells exploit acetylation as a post-translational protein for microenvironmental adaptation, nominating it as a means for dynamic modulation of the phenotypes of cancer cells at the interface between genetics and environments. The objectives of this review were to describe the functional implications of protein lysine acetylation in cancer biology by examining recent evidence that implicates oncogenic signaling as a strong driver of protein acetylation, which might be exploitable for novel therapeutic strategies against cancer.

scholarly journals Protein Acetylation in the Cardiorenal Axis

2010 ◽  
Vol 106 (2) ◽  
pp. 272-284 ◽  
Author(s):  
Erik W. Bush ◽  
Timothy A. McKinsey
Keyword(s):  
Protein Acetylation
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