DNA Minor Groove Binding Agent

2020 ◽  
Author(s):  
Keyword(s):  
Minor Groove ◽  
Minor Groove Binding ◽  
Binding Agent ◽  
Groove Binding ◽  
Dna Minor Groove

scholarly journals DNA Minor Groove Binding with Bisbenzamidine-Ru(II) Complexes

2019 ◽  
Author(s):  
Mateo I. Sánchez ◽  
Gustavo Rama ◽  
Renata Calo ◽  
Kübra Ucar ◽  
Per Lincoln ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Coordination Compounds ◽  
Photophysical Properties ◽  
Organic Ligand ◽  
Minor Groove ◽  
The Other ◽  
Minor Groove Binding ◽  
Binding Agent ◽  
Groove Binding ◽  
Dna Minor Groove

We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis‑benzamidine minor groove DNA-binding agent with a ruthenium(II) complex. Importantly, one of the enantiomers (Δ‑[Ru(bpy)<sub>2</sub><b>b4bpy</b>]<sup>2+</sup>, <b>Δ‑4Ru</b>) shows a considerably higher DNA affinity than the parent organic ligand and than the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.

scholarly journals ATRT-33. TARGETING THE LETHAL PEDIATRIC TUMORS ATRT AND DIPG WITH THE DNA MINOR-GROOVE BINDING AGENT QUINACRINE

2018 ◽  
Vol 20 (suppl_2) ◽  
pp. i34-i35
Author(s):  
Harpreet Kaur ◽  
Huizi Guo ◽  
Smit Shah ◽  
Sepehr Akhtarkhavari ◽  
Charles Eberhart ◽  
...  
Keyword(s):  
Minor Groove ◽  
Pediatric Tumors ◽  
Minor Groove Binding ◽  
Binding Agent ◽  
Groove Binding ◽  
Dna Minor Groove

Mahanine, A DNA Minor Groove Binding Agent Exerts Cellular Cytotoxicity with Involvement of C-7-OH and −NH Functional Groups

2013 ◽  
Vol 56 (14) ◽  
pp. 5709-5721 ◽  
Author(s):  
Suman K. Samanta ◽  
Devawati Dutta ◽  
Sarita Roy ◽  
Kaushik Bhattacharya ◽  
Sayantani Sarkar ◽  
...  
Keyword(s):  
Functional Groups ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Cellular Cytotoxicity ◽  
Binding Agent ◽  
Groove Binding ◽  
Dna Minor Groove

scholarly journals DNA Minor Groove Binding with Bisbenzamidine-Ru(II) Complexes

2019 ◽  
Author(s):  
Mateo I. Sánchez ◽  
Gustavo Rama ◽  
Renata Calo ◽  
Kübra Ucar ◽  
Per Lincoln ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Coordination Compounds ◽  
Photophysical Properties ◽  
Organic Ligand ◽  
Minor Groove ◽  
The Other ◽  
Minor Groove Binding ◽  
Binding Agent ◽  
Groove Binding ◽  
Dna Minor Groove

We report the first Ru(II) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis‑benzamidine minor groove DNA-binding agent with a ruthenium(II) complex. Importantly, one of the enantiomers (Δ‑[Ru(bpy)<sub>2</sub><b>b4bpy</b>]<sup>2+</sup>, <b>Δ‑4Ru</b>) shows a considerably higher DNA affinity than the parent organic ligand and than the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.

scholarly journals Correction to Mahanine, A DNA Minor Groove Binding Agent Exerts Cellular Cytotoxicity with Involvement of C-7-OH and −NH Functional Groups

2019 ◽  
Vol 62 (20) ◽  
pp. 9338-9338
Author(s):  
Suman K. Samanta ◽  
Devawati Dutta ◽  
Sarita Roy ◽  
Kaushik Bhattacharya ◽  
Sayantani Sarkar ◽  
...  
Keyword(s):  
Functional Groups ◽  
Minor Groove ◽  
Minor Groove Binding ◽  
Cellular Cytotoxicity ◽  
Binding Agent ◽  
Groove Binding ◽  
Dna Minor Groove

Influence of GC and AT Specific DNA Minor Groove Binding Drugs on Intermolecular Triplex Formation in the Human c-Ki-ras Promoter†

Biochemistry ◽  
1996 ◽  
Vol 35 (4) ◽  
pp. 1106-1114 ◽  
Author(s):  
Nadarajah Vigneswaran ◽  
Charles A. Mayfield ◽  
Brad Rodu ◽  
Roger James ◽  
H.-G. Kim ◽  
...  
Keyword(s):  
Minor Groove ◽  
Minor Groove Binding ◽  
Groove Binding ◽  
Dna Minor Groove ◽  
Triplex Formation
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