Non-High Density Lipoprotein Cholesterol Measurement

2020 ◽  
Author(s):  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cholesterol Measurement

scholarly journals A Comparison of the Phosphotungstate Magnesium Precipitation and Heparin-Manganese Precipitation Procedures for Estimating High-Density Lipoprotein Cholesterol

1980 ◽  
Vol 17 (2) ◽  
pp. 105-108 ◽  
Author(s):  
GD Calvert ◽  
Rosemary A Yeates ◽  
Tuna Mannik
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Apolipoprotein B ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Final Concentration ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Cholesterol Measurement

The phosphotungstate-MgCl2 method for precipitating very low density and low density lipoproteins from plasma precipitates up to about 7 % of high density lipoprotein. The heparin-MnCl2 method, used at a final MnCl2 concentration of 0092 mol/l, does not seem to precipitate any high density lipoprotein but precipitates essentially all apolipoprotein B containing very low density and low density lipoprotein. When the final concentration of MnCl2 is 0046 mol/l, precipitation of apolipoprotein B containing very low density and low density lipoprotein is frequently incomplete. The herapin-MnCl2 method, when the MnCl2 final concentration is 0·092 mol/l, is the preferred method for high density lipoprotein cholesterol measurement if the cholesterol assay is unaffected by either heparin or MnCl2. High density lipoprotein cholesterol results, using this method, are higher than with the phosphotungstate MgCl2 method and lower than with the heparin MnCl2 method when the MnCl2 final concentration is 0·046 mol/l.

Triglyceride to high density lipoprotein cholesterol ratio, total cholesterol to high density lipoprotein cholesterol ratio and low ankle brachial index in an elderly population

VASA ◽  
2014 ◽  
Vol 43 (3) ◽  
pp. 189-197 ◽  
Author(s):  
Yiqiang Zhan ◽  
Jinming Yu ◽  
Rongjing Ding ◽  
Yihong Sun ◽  
Dayi Hu
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Ankle Brachial Index ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Cholesterol Ratio ◽  
Potential Biomarker

Background: The associations of triglyceride (TG) to high-density lipoprotein cholesterol ratio (HDL‑C) and total cholesterol (TC) to HDL‑C ratio and low ankle brachial index (ABI) were seldom investigated. Patients and methods: A population based cross-sectional survey was conducted and 2982 participants 60 years and over were recruited. TG, TC, HDL‑C, and low-density lipoprotein cholesterol (LDL-C) were assessed in all participants. Low ABI was defined as ABI ≤ 0.9 in either leg. Multiple logistic regression models were applied to study the association between TG/HDL‑C ratio, TC/HDL‑C ratio and low ABI. Results: The TG/HDL‑C ratios for those with ABI > 0.9 and ABI ≤ 0.9 were 1.28 ± 1.20 and 1.48 ± 1.13 (P < 0.0001), while the TC/HDL‑C ratios were 3.96 ± 1.09 and 4.32 ± 1.15 (P < 0.0001), respectively. After adjusting for age, gender, body mass index, obesity, current drinking, physical activity, hypertension, diabetes, lipid-lowering drugs, and cardiovascular disease history, the odds ratios (ORs) with 95 % confidence intervals (CIs) of low ABI for TG/HDL‑C ratio and TC/HDL‑C ratio were 1.10 (0.96, 1.26) and 1.34 (1.14, 1.59) in non-smokers. When TC was further adjusted, the ORs (95 % CIs) were 1.40 (0.79, 2.52) and 1.53 (1.21, 1.93) for TG/HDL‑C ratio and TC/HDL‑C ratio, respectively. Non-linear relationships were detected between TG/HDL‑C ratio and TC/HDL‑C ratio and low ABI in both smokers and non-smokers. Conclusions: TC/HDL‑C ratio was significantly associated with low ABI in non-smokers and the association was independent of TC, TG, HDL‑C, and LDL-C. TC/HDL‑C might be considered as a potential biomarker for early peripheral arterial disease screening.

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