scholarly journals Transcription Factor E2F1

2020 ◽  
Author(s):  
Keyword(s):  
Transcription Factor ◽  
Transcription Factor E2f1

scholarly journals The Transcription Factor E2F1 Modulates Apoptosis of Neurons

2001 ◽  
Vol 75 (1) ◽  
pp. 91-100 ◽  
Author(s):  
Sheng T. Hou ◽  
Debbie Callaghan ◽  
Marie-Christine Fournier ◽  
Irene Hill ◽  
Liping Kang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factor E2f1

scholarly journals Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology

2007 ◽  
Vol 25 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Saori Shimizu ◽  
Muhammad Z. Khan ◽  
Randi L Hippensteel ◽  
Anjum Parkar, ◽  
Ramesh Raghupathi ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factor E2f1

Decreased brain infarct following focal ischemia in mice lacking the transcription factor E2F1

Neuroreport ◽  
1999 ◽  
Vol 10 (13) ◽  
pp. 2711-2714 ◽  
Author(s):  
J P. MacManus ◽  
C J. Koch ◽  
M Jian ◽  
T Walker ◽  
B Zurakowski
Keyword(s):  
Transcription Factor ◽  
Focal Ischemia ◽  
Brain Infarct ◽  
Transcription Factor E2f1

scholarly journals Bim, a Proapoptotic Protein, Up-regulated via Transcription Factor E2F1-dependent Mechanism, Functions as a Prosurvival Molecule in Cancer

2012 ◽  
Vol 288 (1) ◽  
pp. 368-381 ◽  
Author(s):  
Raghu Gogada ◽  
Neelu Yadav ◽  
Junwei Liu ◽  
Shaohua Tang ◽  
Dianmu Zhang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Proapoptotic Protein ◽  
Dependent Mechanism ◽  
Transcription Factor E2f1

scholarly journals Transcription Factor E2F1 Knockout Promotes Mice White Adipose Tissue Browning Through Autophagy Inhibition

2021 ◽  
Vol 12 ◽  
Author(s):  
Mingchen Xiong ◽  
Weijie Hu ◽  
Yufang Tan ◽  
Honghao Yu ◽  
Qi Zhang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Uncoupling Protein ◽  
Underlying Mechanism ◽  
Metabolic Complications ◽  
Autophagy Inhibition ◽  
Transcription Factor E2f1

Obesity is associated with energy metabolic disturbance and is caused by long-term excessive energy storage in white adipose tissue (WAT). The WAT browning potentially reduces excessive energy accumulation, contributing an attractive target to combat obesity. As a pivotal regulator of cell growth, the transcription factor E2F1 activity dysregulation leads to metabolic complications. The regulatory effect and underlying mechanism of E2F1 knockout on WAT browning, have not been fully elucidated. To address this issue, in this study, the in vivo adipose morphology, mitochondria quantities, uncoupling protein 1 (UCP-1), autophagy-related genes in WAT of wild-type (WT) and E2F1–/– mice were detected. Furthermore, we evaluated the UCP-1, and autophagy-related gene expression in WT and E2F1–/– adipocyte in vitro. The results demonstrated that E2F1 knockout could increase mitochondria and UCP-1 expression in WAT through autophagy suppression in mice, thus promoting WAT browning. Besides, adipocytes lacking E2F1 showed upregulated UCP-1 and downregulated autophagy-related genes expression in vitro. These results verified that E2F1 knockout exerted effects on inducing mice WAT browning through autophagy inhibition in vivo and in vitro. These findings regarding the molecular mechanism of E2F1-modulated autophagy in controlling WAT plasticity, provide a novel insight into the functional network with the potential therapeutic application against obesity.

scholarly journals Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1

2015 ◽  
Vol 36 (8) ◽  
pp. 966-975 ◽  
Author(s):  
Qi Ma ◽  
Qing-song Hu ◽  
Ran-jie Xu ◽  
Xue-chu Zhen ◽  
Guang-hui Wang
Keyword(s):  
Transcription Factor ◽  
Neurite Outgrowth ◽  
Mouse Neuroblastoma ◽  
N2a Cells ◽  
Transcription Factor E2f1
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