scholarly journals Tacrine Hydrochloride

2020 ◽  
Author(s):  
Keyword(s):  
Tacrine Hydrochloride

Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's disease

1993 ◽  
Vol 53 (6) ◽  
pp. 691-695 ◽  
Author(s):  
Julia M Ford ◽  
Carol A Truman ◽  
Gordon K Wilcock ◽  
Clive J C Roberts
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Adverse Effects ◽  
Serum Concentrations ◽  
Tacrine Hydrochloride

Effect of tacrine hydrochloride on hepatic drug metabolism

1999 ◽  
Vol 24 (1) ◽  
pp. 91-96
Author(s):  
T. C. Danbury ◽  
M. Eccles ◽  
J. Ford ◽  
C. J. Roberts
Keyword(s):  
Drug Metabolism ◽  
Hepatic Drug Metabolism ◽  
Hepatic Drug ◽  
Tacrine Hydrochloride

scholarly journals Synthesis and crystal structure of 1,2,3,4-tetrahydro-9-aminoacridine tetrachlorozincate(II) monohydrate

2010 ◽  
Vol 75 (9) ◽  
pp. 1209-1218 ◽  
Author(s):  
Djenana Miodragovic ◽  
Dragoljub Jovanovic ◽  
Goran Bogdanovic ◽  
Dragana Mitic ◽  
Katarina Andjelkovic
Keyword(s):  
Hydrogen Bonding ◽  
Complex Anion ◽  
Solvent Molecule ◽  
Tetrahedral Geometry ◽  
Synthesis And Crystal Structure ◽  
Triclinic Crystal System ◽  
Water Solvent ◽  
Tacrine Hydrochloride ◽  
3D Assembly ◽  
Cl Atoms

In the reaction of ZnCl2 with tacrine hydrochloride in water novel tetracoordinated (C13H15N2)2[ZnCl4].H2O complex was obtained and characterized by elemental analysis, molar conductivity and X-ray analysis. The complex crystallizes in the space group P-1 of the triclinic crystal system. The structure contains two crystallographically different molecules of protonated tacrine present as counter cations, the [ZnCl4]2- complex anion and one water solvent molecule. The counter cations slightly differ in the puckering of the cyclohexenyl ring. The molecules of protonated tacrine are involved in different intermolecular hydrogen bonds. In the crystal, the hydrogen bonding generates a 3D assembly. In the crystal, p...p stacking interactions between the rings of protonated tacrine were evidenced. The [ZnCl4]2-complex anion has a distorted tetrahedral geometry. Three out of the four Cl atoms are involved in intermolecular hydrogen bonding. The intermolecular H-bond interactions involving the Cl atoms affect the Zn-Cl bond lengths.

Sign in / Sign up

Export Citation Format

Share Document