scholarly journals Polycystic Kidney Disease Protein 1-Like 1

2020 ◽  
Author(s):  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Polycystic Kidney ◽  
Disease Protein

Translational up‐regulation of polycystic kidney disease protein PKD2 by endoplasmic reticulum stress

2013 ◽  
Vol 27 (12) ◽  
pp. 4998-5009 ◽  
Author(s):  
Jungwoo Yang ◽  
Wang Zheng ◽  
Qian Wang ◽  
Carlos Lara ◽  
Shaimaa Hussein ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Kidney Disease ◽  
Endoplasmic Reticulum Stress ◽  
Polycystic Kidney Disease ◽  
Polycystic Kidney ◽  
Disease Protein

scholarly journals In VivoInteraction of the Adapter Protein CD2-associated Protein with the Type 2 Polycystic Kidney Disease Protein, Polycystin-2

2000 ◽  
Vol 275 (42) ◽  
pp. 32888-32893 ◽  
Author(s):  
Sanna Lehtonen ◽  
Ari Ora ◽  
Vesa M. Olkkonen ◽  
Lin Geng ◽  
Marino Zerial ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Adapter Protein ◽  
Polycystic Kidney ◽  
Disease Protein

scholarly journals The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1.

1996 ◽  
Vol 133 (4) ◽  
pp. 809-817 ◽  
Author(s):  
G W Moy ◽  
L M Mendoza ◽  
J R Schulz ◽  
W J Swanson ◽  
C G Glabe ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Western Blotting ◽  
Sea Urchin ◽  
Polycystic Kidney ◽  
Disease Protein ◽  
Antibody Induction ◽  
Egg Jelly ◽  
Autosomal Dominant Polycystic Kidney ◽  
Sea Urchin Sperm

During fertilization, the sea urchin sperm acrosome reaction (AR), an ion channel-regulated event, is triggered by glycoproteins in egg jelly (EJ). A 210-kD sperm membrane glycoprotein is the receptor for EJ (REJ). This conclusion is based on the following data: purified REJ binds species specifically to EJ dotted onto nitrocellulose, an mAb to REJ induces the sperm AR, antibody induction is blocked by purified REJ, and purified REJ absorbs the AR-inducing activity of EJ. Overlapping fragments of REJ cDNA were cloned (total length, 5,596 bp). The sequence was confirmed by microsequencing six peptides of mature REJ and by Western blotting with antibody to a synthetic peptide designed from the sequence. Complete deglycosylation of REJ followed by Western blotting yielded a size estimate in agreement with that of the mature amino acid sequence. REJ is modular in design; it contains one EGF module and two C-type lectin carbohydrate-recognition modules. Most importantly, it contains a novel module, herein named the REJ module (700 residues), which shares extensive homology with the human polycystic kidney disease protein (PKD1). Mutations in PKD1 cause autosomal dominant polycystic kidney disease, one of the most frequent genetic disease of humans. The lesion in cellular physiology resulting from mutations in the PKD1 protein remains unknown. The homology between REJ modules of the sea urchin REJ and human PKD1 suggests that PKD1 could be involved in ionic regulation.

scholarly journals Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity

2010 ◽  
Vol 19 (17) ◽  
pp. 3306-3319 ◽  
Author(s):  
Jingjing Zhang ◽  
Maoqing Wu ◽  
Shixuan Wang ◽  
Jagesh V. Shah ◽  
Patricia D. Wilson ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Mitotic Spindle ◽  
Polycystic Kidney ◽  
Disease Protein
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