scholarly journals XRCC1 Gene

2020 ◽  
Author(s):  
Keyword(s):  
Xrcc1 Gene

scholarly journals Activated STAT3 Is a Novel Regulator of the XRCC1 Promoter and Selectively Increases XRCC1 Protein Levels in Triple Negative Breast Cancer

2021 ◽  
Vol 22 (11) ◽  
pp. 5475
Author(s):  
Griffin Wright ◽  
Manoj Sonavane ◽  
Natalie R. Gassman
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Excision Repair ◽  
Strand Break ◽  
Xrcc1 Gene ◽  
Single Strand Break ◽  
Expression Levels ◽  
Constitutive Activation ◽  
Gene And Protein Expression

Base Excision Repair (BER) addresses base lesions and abasic sites induced by exogenous and endogenous stressors. X-ray cross complementing group 1 (XRCC1) functions as a scaffold protein in BER and single-strand break repair (SSBR), facilitating and coordinating repair through its interaction with a host of critical repair proteins. Alterations of XRCC1 protein and gene expression levels are observed in many cancers, including colorectal, ovarian, and breast cancer. While increases in the expression level of XRCC1 are reported, the transcription factors responsible for this up-regulation are not known. In this study, we identify the signal transducer and activator of transcription 3 (STAT3) as a novel regulator of XRCC1 through chromatin immunoprecipitation. Activation of STAT3 through phosphorylation at Y705 by cytokine (IL-6) signaling increases the expression of XRCC1 and the occupancy of STAT3 within the XRCC1 promoter. In triple negative breast cancer, the constitutive activation of STAT3 upregulates XRCC1 gene and protein expression levels. Increased expression of XRCC1 is associated with aggressiveness and resistance to DNA damaging chemotherapeutics. Thus, we propose that activated STAT3 regulates XRCC1 under stress and growth conditions, but constitutive activation in cancers results in dysregulation of XRCC1 and subsequently BER and SSBR.

scholarly journals Association of XRCC1 gene polymorphisms with idiopathic azoospermia in a Chinese population

2007 ◽  
Vol 9 (6) ◽  
pp. 781-786 ◽  
Author(s):  
Ai-Hua Gu ◽  
Jie Liang ◽  
Ning-Xia Lu ◽  
Bin Wu ◽  
Yan-Kai Xia ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Chinese Population ◽  
Xrcc1 Gene

scholarly journals The Association of XRCC1 Gene Polymorphisms and Chronic Hepatitis C Induced Insulin Resistance in Egyptian Patients

Cells ◽  
2018 ◽  
Vol 7 (11) ◽  
pp. 185
Author(s):  
Salwa Abo El-khair ◽  
Mona Arafa ◽  
Tarek Besheer ◽  
Ahmed El-Eraky ◽  
Ayman Elsamanoudy
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Gene Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Xrcc1 Gene ◽  
Egyptian Patients ◽  
Pcr Rflp ◽  
Chronic Hcv

Chronic hepatitis C is implicated in insulin resistance (IR) susceptibility. An X-ray repair cross-complementing group 1 gene (XRCC1) is proposed to be a candidate gene for a study of IR susceptibility. So, this study aims to investigate the possible association of the XRCC1 gene polymorphisms with the risk of IR related to chronic hepatitis C virus (HCV) infection in Egyptian patients. In a case-control study, a total of 210 subjects, including 140 chronic HCV patients (87 patients with IR and 53 without IR) and 70 healthy controls, were included. Two genetic polymorphisms (c.1254C > T and c.1517G > C) of the XRCC1 gene were genotyped via the PCR-restriction fragment length polymorphism (PCR-RFLP) technique. The result of the current study revealed that these two single nucleotide polymorphisms (SNPs) have statistically significant influences on susceptibility to IR in chronic HCV infected Egyptian patients. It could be concluded that c.1254C > T, the TT genotype, CT/CC carriers as well as c.1517G > C, the CC genotype and GC/GG carriers might be associated with increased IR susceptibility. Moreover, T-allele of c.1254C > T and the C-allele of c.1517G > C genetic variants might influence the susceptibility.

scholarly journals Association of Arg194Trp and Arg399Gln Polymorphisms of XRCC1 Gene and Risk of Differentiated Thyroid Carcinoma in Iranian-Azeri Patients

2017 ◽  
Vol 10 (7) ◽  
Author(s):  
Mina Adampourezare ◽  
Mohammad-Ali Hosseinpourefeizi ◽  
Nasser Pouladi ◽  
Ehsan Hosseinpourefeizi ◽  
Parvin Azarfam
Keyword(s):  
Thyroid Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Xrcc1 Gene

The association of c.1471G>A genetic polymorphism in XRCC1 gene with lung cancer susceptibility in Chinese Han population

Tumor Biology ◽  
2014 ◽  
Vol 35 (6) ◽  
pp. 5389-5393 ◽  
Author(s):  
Li Wang ◽  
Zhenhong Chen ◽  
Yajuan Wang ◽  
De Chang ◽  
Longxiang Su ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Genetic Polymorphism ◽  
Cancer Susceptibility ◽  
Chinese Han Population ◽  
Xrcc1 Gene ◽  
Chinese Han ◽  
Han Population ◽  
Lung Cancer Susceptibility

XRCC1 Gene Polymorphisms and Risk of Lung Cancer in Turkish Patients

2012 ◽  
Vol 12 (2) ◽  
pp. 113-117 ◽  
Author(s):  
Mutlu Karkucak ◽  
Tahsin Yakut ◽  
Turkkan Evrensel ◽  
Adem Deligonul ◽  
Tuna Gulten ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gene Polymorphisms ◽  
Xrcc1 Gene ◽  
Turkish Patients

scholarly journals Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study

2013 ◽  
Vol 5 (3) ◽  
pp. 959-963 ◽  
Author(s):  
SANIYA NISSAR ◽  
TUFAIL AHMAD LONE ◽  
MUJEEB ZAFAR BANDAY ◽  
ROOHI RASOOL ◽  
NISSAR A. CHOWDRI ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Xrcc1 Gene ◽  
Arg399gln Polymorphism ◽  
Control Study
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