scholarly journals EDAR Gene

2020 ◽  
Author(s):  
Keyword(s):  
Edar Gene

scholarly journals Single Nucleotide Polymorphism Discovery and Genetic Differentiation Analysis of Geese Bred in Poland, Using Genotyping-by-Sequencing (GBS)

Genes ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 1074
Author(s):  
Joanna Grzegorczyk ◽  
Artur Gurgul ◽  
Maria Oczkowicz ◽  
Tomasz Szmatoła ◽  
Agnieszka Fornal ◽  
...  
Keyword(s):  
Genotyping By Sequencing ◽  
Read Depth ◽  
Model Organisms ◽  
Single Nucleotide Polymorphism Discovery ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Polymorphism Discovery ◽  
Genome Wide ◽  
Plumage Development ◽  
Edar Gene

Poland is the largest European producer of goose, while goose breeding has become an essential and still increasing branch of the poultry industry. The most frequently bred goose is the White Kołuda® breed, constituting 95% of the country’s population, whereas geese of regional varieties are bred in smaller, conservation flocks. However, a goose’s genetic diversity is inaccurately explored, mainly because the advantages of the most commonly used tools are strongly limited in non-model organisms. One of the most accurate used markers for population genetics is single nucleotide polymorphisms (SNP). A highly efficient strategy for genome-wide SNP detection is genotyping-by-sequencing (GBS), which has been already widely applied in many organisms. This study attempts to use GBS in 12 conservative goose breeds and the White Kołuda® breed maintained in Poland. The GBS method allowed for the detection of 3833 common raw SNPs. Nevertheless, after filtering for read depth and alleles characters, we obtained the final markers panel used for a differentiation analysis that comprised 791 SNPs. These variants were located within 11 different genes, and one of the most diversified variants was associated with the EDAR gene, which is especially interesting as it participates in the plumage development, which plays a crucial role in goose breeding.

Analysis of the canine EDAR gene and exclusion as a candidate for the hairless phenotype in the Chinese Crested dog

2005 ◽  
Vol 36 (2) ◽  
pp. 168-171 ◽  
Author(s):  
P. Sander ◽  
C. Drogemuller ◽  
E. Cadieu ◽  
C. Andre ◽  
T. Leeb
Keyword(s):  
Edar Gene

scholarly journals Generation of Cashmere Goats Carrying an EDAR Gene Mutant Using CRISPR-Cas9-Mediated Genome Editing

2018 ◽  
Vol 14 (4) ◽  
pp. 427-436 ◽  
Author(s):  
Fei Hao ◽  
Wei Yan ◽  
Xiaocong Li ◽  
Hui Wang ◽  
Yingmin Wang ◽  
...  
Keyword(s):  
Genome Editing ◽  
Gene Mutant ◽  
Cashmere Goats ◽  
Edar Gene

scholarly journals Ectodysplasin signalling genes and phenotypic evolution in sculpins ( Cottus )

2015 ◽  
Vol 282 (1815) ◽  
pp. 20150746 ◽  
Author(s):  
Jie Cheng ◽  
Fritz Sedlazek ◽  
Janine Altmüller ◽  
Arne W. Nolte
Keyword(s):  
Body Shape ◽  
Morphological Evolution ◽  
Genomic Region ◽  
Phenotypic Evolution ◽  
Natural Hybrid ◽  
Microevolutionary Change ◽  
Trait Locus ◽  
Locus Mapping ◽  
Edar Gene

Despite their deeply conserved function among vertebrates, ectodysplasin (Eda) signalling genes are involved in microevolutionary change in humans and sticklebacks. If such a dual role is common, Eda signalling genes constitute hotspots for morphological evolution. Variation in sculpin ( Cottus ) skin prickling and body shape resembles patterns caused by variation in Eda signalling in sticklebacks. We mapped Eda signalling genes and performed quantitative trait locus mapping in crosses between Cottus rhenanus and Cottus perifretum . A genomic region containing the Eda receptor (Edar) was strongly associated with prickling and contributed to shape. The expression of Edar in developing prickles and skeletal elements in Cottus was confirmed by in situ hybridization. Coding sequence changes between Edar alleles in C. rhenanus and C. perifretum exceeded sequence differentiation in other vertebrates. However, it is likely that additional genetic elements besides coding changes affect the phenotypic variation. Although the phenotype in a natural hybrid lineage between C. rhenanus and C. perifretum resembles C. perifretum , the respective coding Edar alleles are not fully fixed (88.6%). Hence, our results support an involvement of Eda signalling in microevolutionary changes, but imply that the Edar gene is affected by multiple evolutionary processes that vary among freshwater sculpins.

scholarly journals A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia

2008 ◽  
Vol 124 (2) ◽  
pp. 179-185 ◽  
Author(s):  
Akihiro Fujimoto ◽  
Jun Ohashi ◽  
Nao Nishida ◽  
Taku Miyagawa ◽  
Yasuyuki Morishita ◽  
...  
Keyword(s):  
Population Differentiation ◽  
Replication Study ◽  
Major Contributor ◽  
Head Hair ◽  
Edar Gene

scholarly journals A Rare Case of Hypohidrotic Ectodermal Dysplasia Caused by Compound Heterozygous Mutations in the EDAR Gene

2004 ◽  
Vol 123 (4) ◽  
pp. 649-655 ◽  
Author(s):  
Yutaka Shimomura ◽  
Nobuyuki Sato ◽  
Akinori Miyashita ◽  
Tsuyoshi Hashimoto ◽  
Masaaki Ito ◽  
...  
Keyword(s):  
Rare Case ◽  
Ectodermal Dysplasia ◽  
Compound Heterozygous ◽  
Hypohidrotic Ectodermal Dysplasia ◽  
Compound Heterozygous Mutations ◽  
Edar Gene
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