scholarly journals Recombinant Haplotype

2020 ◽  
Author(s):  
Keyword(s):  
Recombinant Haplotype

scholarly journals Recombination within the HLA-D region. Correlation of molecular genotyping with functional data.

1984 ◽  
Vol 160 (1) ◽  
pp. 222-238 ◽  
Author(s):  
M A Robinson ◽  
E O Long ◽  
A H Johnson ◽  
R J Hartzman ◽  
B Mach ◽  
...  
Keyword(s):  
Functional Data ◽  
Southern Blot Analysis ◽  
Hla Typing ◽  
Subtle Difference ◽  
Molecular Genotyping ◽  
Recombinant Haplotype ◽  
Allelic Differences ◽  
D Region ◽  
The Individual ◽  
Hla Haplotypes

Molecular genotyping of the HLA-D/DR region in a family correlated with serologic and cellular typing data. It was further possible to predict a subtle difference in SB region-related functions from such molecular studies. A family that included an individual who inherited an HLA haplotype with a paternal recombination between HLA-B and the HLA-D/DR region was identified by classic HLA typing techniques. Segregation of HLA-D/DR region genes in this family was studied by Southern blot analysis using cDNA probes for DR alpha, DR beta, DC alpha, DC beta, and SB beta. Restriction enzyme fragment polymorphisms observed for every gene tested were in concordance with assigned HLA haplotypes (including the individual known to have inherited a paternal recombinant haplotype) with one exception: two HLA identical siblings were observed to have different SB beta restriction fragment patterns. Further testing revealed that one individual inherited a maternal HLA haplotype recombinant between the HLA-D/DR region and SB beta. Although both maternal SB alleles typed as SB4, allelic differences could be detected cellularly by primed lymphocytes and by the differential expression of a class II cell surface antigen using monoclonal antibody. Therefore, predicted and nonpredicted recombinant haplotypes were detected in a family by molecular genotyping.

scholarly journals Rare and fleeting: an example of interspecific recombination in animal mitochondrial DNA

2007 ◽  
Vol 3 (5) ◽  
pp. 554-557 ◽  
Author(s):  
Kate L Ciborowski ◽  
Sofía Consuegra ◽  
Carlos García de Leániz ◽  
Mark A Beaumont ◽  
Jinliang Wang ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Atlantic Salmon ◽  
Salmo Trutta ◽  
Sequence Divergence ◽  
F1 Hybrid ◽  
Phylogenetic Studies ◽  
Recombinant Haplotype ◽  
The Individual ◽  
Historical Variation ◽  
Interspecific Recombination

Recombination is thought to occur only rarely in animal mitochondrial DNA (mtDNA). However, detection of mtDNA recombination requires that cells become heteroplasmic through mutation, intramolecular recombination or ‘leakage’ of paternal mtDNA. Interspecific hybridization increases the probability of detecting mtDNA recombinants due to higher levels of sequence divergence and potentially higher levels of paternal leakage. During a study of historical variation in Atlantic salmon ( Salmo salar ) mtDNA, an individual with a recombinant haplotype containing sequence from both Atlantic salmon and brown trout ( Salmo trutta ) was detected. The individual was not an F1 hybrid but it did have an unusual nuclear genotype which suggested that it was a later-generation backcross. No other similar recombinant haplotype was found from the same population or three neighbouring Atlantic salmon populations in 717 individuals collected during 1948–2002. Interspecific recombination may increase mtDNA variability within species and can have implications for phylogenetic studies.

scholarly journals Complexity and approximation of the minimum recombinant haplotype configuration problem

2007 ◽  
Vol 378 (3) ◽  
pp. 316-330 ◽  
Author(s):  
Lan Liu ◽  
Chen Xi ◽  
Jing Xiao ◽  
Tao Jiang
Keyword(s):  
Recombinant Haplotype ◽  
Configuration Problem

scholarly journals Narrow Genetic Diversity of Wolbachia Symbionts in Acrididae Grasshopper Hosts (Insecta, Orthoptera)

2022 ◽  
Vol 23 (2) ◽  
pp. 853
Author(s):  
Yury Ilinsky ◽  
Mary Demenkova ◽  
Roman Bykov ◽  
Alexander Bugrov
Keyword(s):  
Genetic Diversity ◽  
Genetic Analysis ◽  
Multilocus Sequence Typing ◽  
Horizontal Transmission ◽  
Crucial Issue ◽  
High Incidence ◽  
Recombinant Haplotype ◽  
Ftsz Gene

Bacteria of the Wolbachia genus are maternally inherited symbionts of Nematoda and numerous Arthropoda hosts. There are approximately 20 lineages of Wolbachia, which are called supergroups, and they are designated alphabetically. Wolbachia strains of the supergroups A and B are predominant in arthropods, especially in insects, and supergroup F seems to rank third. Host taxa have been studied very unevenly for Wolbachia symbionts, and here, we turn to one of largely unexplored insect families: Acrididae. On the basis of five genes subject to multilocus sequence typing, we investigated the incidence and genetic diversity of Wolbachia in 41 species belonging three subfamilies (Gomphocerinae, Oedipodinae, and Podisminae) collected in Turkey, Kazakhstan, Tajikistan, Russia, and Japan, making 501 specimens in total. Our results revealed a high incidence and very narrow genetic diversity of Wolbachia. Although only the strains belonging to supergroups A and B are commonly present in present, the Acrididae hosts here proved to be infected with supergroups B and F without A-supergroup variants. The only trace of an A-supergroup lineage was noted in one case of an inter-supergroup recombinant haplotype, where the ftsZ gene came from supergroup A, and the others from supergroup B. Variation in the Wolbachia haplotypes in Acrididae hosts within supergroups B and F was extremely low. A comprehensive genetic analysis of Wolbachia diversity confirmed specific features of the Wolbachia allelic set in Acrididae hosts. This result can help to elucidate the crucial issue of Wolbachia biology: the route(s) and mechanism(s) of Wolbachia horizontal transmission.

scholarly journals The role of subregions of the rat major histocompatibility complex in the rejection and passive enhancement of renal allografts.

1979 ◽  
Vol 149 (1) ◽  
pp. 244-253 ◽  
Author(s):  
G G Gallico ◽  
G W Butcher ◽  
J C Howard
Keyword(s):  
Major Histocompatibility Complex ◽  
Acute Rejection ◽  
Major Histocompatibility ◽  
Norway Rat ◽  
Renal Allografts ◽  
Histocompatibility Complex ◽  
Single Region ◽  
Recombinant Haplotype ◽  
Histocompatibility Locus

The laboratory recombinant haplotype H-1acl of the Norway rat has been used in studies of the rejection and passive enhancement of kidney allografts. While the full H-1a haplotype provoked acute rejection, neither of the isolated subregions, H-1Aa and H-1Ba, did so. It was also found that alloantisera raised against either the H-1Aa or the H-1Ba antigens would enhance the grafts. It is suggested that both MHC subregions contain a histocompatibility locus (i) for kidney (as they do for skin) and that in the genetic combinations studied only incompatibility for both provokes a response sufficient for rejection. In other combinations, however, single region incompatibilities may be sufficient.

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