High Endothelial Venule

2020 ◽  
Author(s):  
Keyword(s):  
High Endothelial Venule

Anti-high endothelial venule monoclonal antibody HECA-452 recognizes plasmacytoid T cells and delineates an ”extranodular“ compartment in the reactive lymph node

1989 ◽  
Vol 20 (4) ◽  
pp. 277-281 ◽  
Author(s):  
F. Facchetti ◽  
Chris de Wolf-Peeters ◽  
J.J. van den Oord ◽  
C.J.L.M. Meijer ◽  
S.T. Pals ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Cells ◽  
Lymph Node ◽  
High Endothelial Venule ◽  
Reactive Lymph Node

Plasticity of endothelial cells: rapid dedifferentiation of freshly isolated high endothelial venule endothelial cells outside the lymphoid tissue microenvironment

Blood ◽  
2004 ◽  
Vol 103 (11) ◽  
pp. 4164-4172 ◽  
Author(s):  
Delphine-Armelle Lacorre ◽  
Espen S. Baekkevold ◽  
Ignacio Garrido ◽  
Per Brandtzaeg ◽  
Guttorm Haraldsen ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Lymphoid Tissue ◽  
Ex Vivo ◽  
Primary Cultures ◽  
High Endothelial Venule ◽  
Tissue Specific ◽  
Tissue Microenvironment ◽  
Cell Phenotypes

Abstract Endothelial cells display remarkable heterogeneity in different organs and vascular beds. Although many studies suggest that tissues “speak” to endothelial cells, endothelial cell diversity remains poorly characterized at the molecular level. Here, we describe a novel strategy to characterize tissue-specific endothelial cell phenotypes and to identify endothelial cell genes that are under the control of the local microenvironment. By comparing post-capillary high endothelial venule endothelial cells (HEVECs), freshly isolated from human tonsils without any cell culture step, with HEVECs cultured for 2 days, we found that HEVECs rapidly lost their specialized characteristics when isolated from the lymphoid tissue microenvironment. Striking changes occurred as early as after 48 hours, with complete loss of the postcapillary venule–specific Duffy antigen receptor for chemokines (DARCs) and the HEV-specific fucosyltransferase Fuc-TVII. DNA microarray analysis identified several other candidate HEV genes that were rapidly down-regulated ex vivo, including type XV collagen, which we characterized as a novel, abundant HEV transcript in situ. Together, our results demonstrate that blood vessel type–specific and tissue-specific characteristics of endothelial cells are under the control of their microenvironment. Therefore, even short-term primary cultures of human endothelial cells may not adequately mimic the differentiated endothelial cell phenotypes existing in vivo.

scholarly journals A High Endothelial Venule Secretory Protein, Mac25/Angiomodulin, Interacts with Multiple High Endothelial Venule-Associated Molecules Including Chemokines

2003 ◽  
Vol 171 (2) ◽  
pp. 553-561 ◽  
Author(s):  
Daisuke Nagakubo ◽  
Toshiyuki Murai ◽  
Toshiyuki Tanaka ◽  
Takeo Usui ◽  
Masanori Matsumoto ◽  
...  
Keyword(s):  
Secretory Protein ◽  
High Endothelial Venule

Preferential Induction of Peripheral Lymph Node Addressin on High Endothelial Venule-Like Vessels in the Active Phase of Ulcerative Colitis

2007 ◽  
Vol 102 (7) ◽  
pp. 1499-1509 ◽  
Author(s):  
Kenichi Suzawa ◽  
Motohiro Kobayashi ◽  
Yasuhiro Sakai ◽  
Hitomi Hoshino ◽  
Matsuko Watanabe ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Lymph Node ◽  
Active Phase ◽  
High Endothelial Venule ◽  
Peripheral Lymph Node ◽  
Peripheral Lymph

scholarly journals Simultaneous targeting of primary tumor, draining lymph node, and distant metastases through high endothelial venule-targeted delivery

Nano Today ◽  
2021 ◽  
Vol 36 ◽  
pp. 101045
Author(s):  
Liwei Jiang ◽  
Sungwook Jung ◽  
Jing Zhao ◽  
Vivek Kasinath ◽  
Takaharu Ichimura ◽  
...  
Keyword(s):  
Lymph Node ◽  
Targeted Delivery ◽  
Primary Tumor ◽  
Distant Metastases ◽  
High Endothelial Venule ◽  
Draining Lymph Node ◽  
Tumor Draining Lymph Node
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