scholarly journals Reverse Triiodothyronine Measurement

2020 ◽  
Author(s):  
Keyword(s):  
Reverse Triiodothyronine

THE RELATIVE DISTRIBUTION OF THYROXINE, TRIIODOTHYRONINE AND 3,3′,5′-(REVERSE)-TRIIODOTHYRONINE IN VARIOUS FRACTIONS OF THYROGLOBULIN

1978 ◽  
Vol 88 (2) ◽  
pp. 298-305 ◽  
Author(s):  
Peter Laurberg
Keyword(s):  
Ionic Strength ◽  
Guinea Pig ◽  
Sucrose Gradient ◽  
Deae Cellulose ◽  
High Ionic Strength ◽  
Relative Distribution ◽  
Thyroid Extract ◽  
Reverse Triiodothyronine ◽  
Thyroid Secretion ◽  
Stable Iodine

ABSTRACT Thyroglobulin fractions rich and poor in new thyroglobulin were separated by means of DEAE-cellulose chromatography of dog thyroid extracts and by zonal ultracentrifugation in a sucrose gradient of guinea pig thyroid extract incubated at low temperature. The distribution of thyroxine, triiodothyronine and 3,3′,5′-(reverse)-triiodothyronine in hydrolysates of the different fractions was estimated by radioimmunoassays. Following DEAE-cellulose chromatography there was a small but statistically significant increase in the T4/T3 ratio in thyroglobulin fractions eluted at high ionic strength - that is fractions relatively rich in stable iodine but poor in fresh thyroglobulin. There were no differences in the T4/rT3 ratios between the different fractions. The ratios between iodothyronines were almost identical in the various thyroglobulin fractions following zonal ultracentrifugation in a sucrose gradient of cold treated guinea pig thyroid extract. These findings lend no support to the possibility that a relatively high content of triiodothyronines in freshly synthesized thyroglobulin modulates the thyroid secretion towards a preferential secretion of triiodothyronine and 3,3′,5′-(reverse)-triiodothyronine at the expense of the secretion of thyroxine.

Increased serum reverse triiodothyronine levels at diagnosis of hepatocellular carcinoma in patients with compensated HCV-related liver cirrhosis

2003 ◽  
Vol 58 (2) ◽  
pp. 207-212 ◽  
Author(s):  
Francesca Sorvillo ◽  
Gherardo Mazziotti ◽  
Antonella Carbone ◽  
Filomena Morisco ◽  
Michele Cioffi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Reverse Triiodothyronine

Relation of Triiodothyronine and Reverse Triiodothyronine Administration in Rats to Hepatic L-Triiodothyronine Aminotransferase Activity1

Endocrinology ◽  
1977 ◽  
Vol 100 (4) ◽  
pp. 1055-1059 ◽  
Author(s):  
NORMAN FISHMAN ◽  
YEE PING HUANG ◽  
DORIAN C. TERGIS ◽  
RICHARD S. RIVLIN
Keyword(s):  
Reverse Triiodothyronine

Acute changes in biliary excretion of reverse triiodothyronine in rats after insulin-induced hypoglycemia: effect of glucose, verapamil, cycloheximide and actinomycin D

1995 ◽  
Vol 132 (5) ◽  
pp. 618-621 ◽  
Author(s):  
Pavel Langer ◽  
Klaudia Gschwendtová
Keyword(s):  
Protein Synthesis ◽  
Metabolic Activity ◽  
Biliary Excretion ◽  
Actinomycin D ◽  
Slovak Academy ◽  
Similar Increase ◽  
Reverse Triiodothyronine ◽  
Acute Changes ◽  
Academy Of Sciences ◽  
Effect Of Glucose

Langer P, Gschwendtová K. Acute changes in biliary excretion of reverse triiodothyronine in rats after insulin-induced hypoglycemia: effect of glucose, verapamil, cycloheximide and actinomycin D. Eur J Endocrinol 1995;132:618–21. ISSN 0804–4643 Biliary excretion of reverse triiodothyronine (rT3) was estimated in rats during hypoglycemia induced by a 10-min infusion of 1 U of insulin (INS) and for the following 5 h. During that period an increase in biliary rT3 was found. This was seen also during the infusion of exogenous glucagon (10 μg in 1.2 ml of saline per 1 h for 5 h) given independently of INS. The infusion of glucose (1 g/kg per 50 min or 2 g/kg per 110 min) following INS infusion delayed the increase in rT3. The increase in rT3 was prevented by actinomycin D (1 mg/kg) when injected before (90 min), but not after (30 min) INS, and also by cycloheximide (2.5 mg/kg) injected immediately before INS. The same dose of cycloheximide also prevented a similar increase of rT3 during the infusion of exogenous glucagon. Verapamil (5 mg/ kg divided into five doses per 4 h) blunted the increase of rT3. These data indicate that following INS injection counter-regulatory hormones may be responsible for the increased production of rT3; this altered metabolic activity apparently is dependent on protein synthesis. Pavel Langer, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlárska 3, 833 06 Bratislava, Slovakia

Monodeiodination of Triiodothyronine and Reverse Triiodothyronine During Low and High Calorie Diets*

1987 ◽  
Vol 65 (5) ◽  
pp. 829-835 ◽  
Author(s):  
ALBERT G. BURGER ◽  
MAUREEN O'CONNELL ◽  
KARL SCHEIDEGGER ◽  
ROSY WOO ◽  
ELLIOT DANFORTH
Keyword(s):  
Reverse Triiodothyronine ◽  
High Calorie

Appearance of Labeled Metabolites in the Serum of Man after the Administration of Labeled Thyroxine, Triiodothyronine (T3), and Reverse Triiodothyronine (rT3)*

1978 ◽  
Vol 46 (6) ◽  
pp. 923-928 ◽  
Author(s):  
MERRITT RUDOLPH ◽  
TOSHIRO SAKURADA ◽  
SHIH-LIEH FANG ◽  
APOSTOLOS G. VAGENAKIS ◽  
LEWIS E. BRAVERMAN ◽  
...  
Keyword(s):  
Reverse Triiodothyronine
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