scholarly journals Cellular Secretion

2020 ◽  
Author(s):  
Keyword(s):  
Cellular Secretion

Effects of Hypophysectomy on the Occurrence and Calcifiability of Matrix Vesicles in the Epiphyseal Growth Plate of Immature Rats

1980 ◽  
Vol 38 ◽  
pp. 578-579
Author(s):  
S. I. Coleman ◽  
W. J. Dougherty
Keyword(s):  
Growth Plate ◽  
Matrix Vesicles ◽  
Epiphyseal Growth Plate ◽  
Hard Tissue ◽  
Hormonal Factors ◽  
Post Surgery ◽  
Mineral Deposition ◽  
Thin Sectioning ◽  
Integral Role ◽  
Cellular Secretion

In the cellular secretion theory of mineral deposition, extracellular matrix vesicles are believed to play an integral role in hard tissue mineralization (1). Membrane limited matrix vesicles arise from the plasma membrane of epiphyseal chondrocytes and tooth odontoblasts by a budding process (2, 3). Nutritional and hormonal factors have been postulated to play essential roles in mineral deposition and apparently have a direct effect on matrix vesicles of calcifying cartilage as concluded by Anderson and Sajdera (4). Immature (75-85 gm) Long-Evans hooded rats were hypophysectomized by the parapharyngeal approach and maintained fourteen (14) days post-surgery. At this time, the animals were anesthetized and perfusion fixed in cacodylate buffered 2.5% glutaraldehyde. The proximal tibias were quickly dissected out and split sagittally. One half was used for light microscopy (LM) and the other for electron microscopy (EM). The halves used for EM were cut into blocks approximately 1×3 mm. The tissue blocks were prepared for ultra-thin sectioning and transmission EM. The tissue was oriented so as to section through the epiphyseal growth plate from the zone of proliferating cartilage on down through the hypertrophic zone and into the initial trabecular bone. Sections were studied stained (double heavy metal) and unstained.

scholarly journals Author response: The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

2018 ◽  
Author(s):  
Brian T Emmer ◽  
Geoffrey G Hesketh ◽  
Emilee Kotnik ◽  
Vi T Tang ◽  
Paul J Lascuna ◽  
...  
Keyword(s):  
Author Response ◽  
Cargo Receptor ◽  
Cellular Secretion

scholarly journals B-Type Natriuretic Peptide: From Posttranslational Processing to Clinical Measurement

2012 ◽  
Vol 58 (1) ◽  
pp. 83-91 ◽  
Author(s):  
Jens P Goetze
Keyword(s):  
Natriuretic Peptide ◽  
Endocrine Cells ◽  
Peptide Structure ◽  
Molecular Heterogeneity ◽  
Posttranslational Processing ◽  
Peptide Fragments ◽  
Molecular Precursors ◽  
Cardiac Pathophysiology ◽  
Cellular Secretion

Abstract BACKGROUND Plasma cardiac natriuretic peptides and peptide fragments from their molecular precursors are markers of heart disease. Clinical studies have defined the current diagnostic utility of these markers, whereas biochemical elucidation of peptide structure and posttranslational processing has revealed new plasma peptide forms of potential clinical use. CONTENT Natriuretic propeptide structures undergo variable degrees of endo- and exoproteolytic cleavages as well as amino acid modifications, which leave the plasma phase of the peptides highly heterogeneous and dependent on cardiac pathophysiology and capacity. An ongoing characterization of the molecular heterogeneity may not only help us to appreciate the biosynthetic capacity of the endocrine heart but may also lead to the discovery of new and more disease-specific targets for future molecular diagnosis. SUMMARY Peptides derived from pro–atrial natriuretic peptide and pro–B-type natriuretic peptide are useful plasma markers in heart failure. New data have defined cardiac myocytes as competent endocrine cells in posttranslational processing and cellular secretion.

Synthetic Cellular Communication-Based Screening for Strains with Improved 3-Hydroxypropionic Acid Secretion

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Seungjin Kim ◽  
Si Hyung Jin ◽  
Hyun Gyu Lim ◽  
Byungjin Lee ◽  
Jaesung Kim ◽  
...  
Keyword(s):  
Acid Secretion ◽  
Analytical Methods ◽  
Cellular Communication ◽  
Industrial Biotechnology ◽  
Microfluidic Platform ◽  
Hydroxypropionic Acid ◽  
Cellular Secretion

Although cellular secretion is important in industrial biotechnology, its assessment is difficult due to the lack of efficient analytical methods. This study describes a synthetic cellular communication-based microfluidic platform for...

Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration

2019 ◽  
Vol 77 (7) ◽  
pp. 1421-1434 ◽  
Author(s):  
Ridwan Babatunde Ibrahim ◽  
Ssu-Yu Yeh ◽  
Kon-Ping Lin ◽  
Frans Ricardo ◽  
Tsyr-Yan Yu ◽  
...  
Keyword(s):  
Late Onset ◽  
Mutant Proteins ◽  
Cellular Secretion

The Bodily and Mental Individuality of the Woman and her Insanities [L'Individualità somato-psichica della Donna e le sue Frenopathie]. (Il Manicomio, Anno xvii, Nos. 1, 2.) Del Greco

1902 ◽  
Vol 48 (200) ◽  
pp. 169-170
Author(s):  
William W. Ireland
Keyword(s):  
Sympathetic Ganglia ◽  
Male And Female ◽  
Outer World ◽  
The Feminine ◽  
Structural Differences ◽  
Cellular Secretion

This thoughtful paper treats of the different characters of nervous diseases manifested in women from those in man. It groups the mental alienations of women into six classes, distinguished by temperament, and profound alterations of constitution brought about by disease. In the mental derangements of the female, observes the professor, there is a more pervading change in the whole temperament, not only mental perversions, but a multiplicity of organic sensations which act upon the entire personality, inducing states of exaltation and depression, emotions of joy and grief, of fear and anger. These complex changes sometimes culminate in the reeling of altered personality. The structural differences between the male and female render the latter less able to react upon external nature. Her frame is adapted to maternity, conception, gestation, labour, lactation; then the renewal of the periods induces profound changes in her organism. These functions affect even the disposition of the bones and ligaments, the increase and diminution of the unstriped muscular fibres, the activity of the sympathetic ganglia, the vascularisation of organs, and the augmented cellular secretion and enlargement of the glands. The totality of changes, so diverse and profound, subject the feminine constitution to grave fluctuations, which alter its relations to the outer world and affect the psychical manifestations.

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