scholarly journals Suppressor of Fused Homolog

2020 ◽  
Author(s):  
Keyword(s):  
Suppressor Of Fused

Abstract B29: Inactivation of suppressor of fused alone is not sufficient to cause medulloblastoma

2009 ◽  
Author(s):  
Thevagi Satkunendran ◽  
Ryan J. Ward ◽  
Peter B. Dirks ◽  
Chi-chung Hui
Keyword(s):  
Suppressor Of Fused

scholarly journals Protein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused

2020 ◽  
Vol 11 (8) ◽  
Author(s):  
Hengqing Liao ◽  
Jing Cai ◽  
Chen Liu ◽  
Longyan Shen ◽  
Xiaohong Pu ◽  
...  
Keyword(s):  
Protein Phosphatase ◽  
Hedgehog Signaling ◽  
Suppressor Of Fused

scholarly journals Cadherin-7 enhances Sonic Hedgehog signalling by preventing Gli3 repressor formation during neural tube patterning

Open Biology ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. 170225 ◽  
Author(s):  
Rie Kawano ◽  
Kunimasa Ohta ◽  
Giuseppe Lupo
Keyword(s):  
Spinal Cord ◽  
Sonic Hedgehog ◽  
Neural Tube ◽  
Target Genes ◽  
Dorsoventral Patterning ◽  
Dorsal Spinal Cord ◽  
Suppressor Of Fused ◽  
Intracellular Movement ◽  
Sonic Hedgehog Signalling ◽  
Dorsal Spinal

Sonic Hedgehog (Shh) is a ventrally enriched morphogen controlling dorsoventral patterning of the neural tube. In the dorsal spinal cord, Gli3 protein bound to suppressor-of-fused (Sufu) is converted into Gli3 repressor (Gli3R), which inhibits Shh-target genes. Activation of Shh signalling prevents Gli3R formation, promoting neural tube ventralization. We show that cadherin-7 (Cdh7) expression in the intermediate spinal cord region is required to delimit the boundary between the ventral and the dorsal spinal cord. We demonstrate that Cdh7 functions as a receptor for Shh and enhances Shh signalling. Binding of Shh to Cdh7 promotes its aggregation on the cell membrane and association of Cdh7 with Gli3 and Sufu. These interactions prevent Gli3R formation and cause Gli3 protein degradation. We propose that Shh can act through Cdh7 to limit intracellular movement of Gli3 protein and production of Gli3R, thus eliciting more efficient activation of Gli-dependent signalling.

Genomic organization, chromosomal assignment, and expression analysis of the mouse Suppressor of fused gene (Sufu) coding a Gli protein partner

2000 ◽  
Vol 11 (8) ◽  
pp. 614-621 ◽  
Author(s):  
Dominique Simon-Chazottes ◽  
Mélanie Paces-Fessy ◽  
Claudie Lamour-Isnard ◽  
Jean-Louis Guénet ◽  
Marie-Françoise Blanchet-Tournier
Keyword(s):  
Expression Analysis ◽  
Genomic Organization ◽  
Chromosomal Assignment ◽  
Suppressor Of Fused ◽  
Protein Partner ◽  
Fused Gene

scholarly journals Loss of Suppressor of Fused in Mid-Corticogenesis Leads to the Expansion of Intermediate Progenitors

2016 ◽  
Vol 4 (4) ◽  
pp. 29 ◽  
Author(s):  
Odessa Yabut ◽  
Hui Ng ◽  
Gloria Fernandez ◽  
Keejung Yoon ◽  
Jeremy Kuhn ◽  
...  
Keyword(s):  
Suppressor Of Fused ◽  
Intermediate Progenitors

scholarly journals Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs

2006 ◽  
Vol 291 (1) ◽  
pp. 53-66 ◽  
Author(s):  
François Dussillol-Godar ◽  
Jeanine Brissard-Zahraoui ◽  
Bernadette Limbourg-Bouchon ◽  
Dominique Boucher ◽  
Sylvaine Fouix ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Imaginal Discs ◽  
Drosophila Embryo ◽  
Hedgehog Signaling Pathway ◽  
Suppressor Of Fused

scholarly journals Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression

2010 ◽  
Vol 107 (50) ◽  
pp. 21795-21800 ◽  
Author(s):  
C. D. Pozniak ◽  
A. J. Langseth ◽  
G. J. P. Dijkgraaf ◽  
Y. Choe ◽  
Z. Werb ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Suppressor Of Fused

Mammalian Suppressor-of-Fused modulates nuclear–cytoplasmic shuttling of GLI-1

10.1038/13031 ◽  
1999 ◽  
Vol 1 (5) ◽  
pp. 312-319 ◽  
Author(s):  
Priit Kogerman ◽  
Thomas Grimm ◽  
Lembi Kogerman ◽  
Darren Krause ◽  
Anne Birgitte Undén ◽  
...  
Keyword(s):  
Suppressor Of Fused ◽  
Gli 1
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