scholarly journals Paraneoplastic Antibody Positive

2020 ◽  
Author(s):  
Keyword(s):  
Paraneoplastic Antibody

Yet another paraneoplastic antibody

2001 ◽  
Vol 49 (2) ◽  
pp. 141-142 ◽  
Author(s):  
Jerome B. Posner ◽  
Josep O. Dalmau
Keyword(s):  
Paraneoplastic Antibody

A 59-Year-Old Man with Progressive Difficulties with Balance and Weight Loss

2016 ◽  
Author(s):  
Jeffrey A. Cohen ◽  
Justin J. Mowchun ◽  
Victoria H. Lawson ◽  
Nathaniel M. Robbins
Keyword(s):  
Weight Loss ◽  
Differential Diagnosis ◽  
Peripheral Neuropathy ◽  
Cerebral Spinal Fluid ◽  
Treatment Options ◽  
Peripheral Neuropathies ◽  
Serum Antibodies ◽  
Paraneoplastic Neuropathy ◽  
Work Up ◽  
Paraneoplastic Antibody

Paraneoplastic peripheral neuropathies are rare but important to consider in the evaluation of subacute peripheral neuropathy. The clinical and electrophysiological pattern as well as antibody evaluation is essential order to identify a specific paraneoplastic neuropathy. A positive paraneoplastic antibody in the cerebral spinal fluid is not required to make the diagnosis, but is helpful to consider if the serum antibodies are negative. This chapter emphasizes the importance of differential diagnosis and work up. Treatment options are described. Immunotherapy is also an important consideration.

Influence of Autoimmune Antibody Testing on the Use of Immunotherapy on an Inpatient Neurology Service

2020 ◽  
pp. 194187442097776
Author(s):  
Kristin Galetta ◽  
Galina Gheihman ◽  
Amy Rosen ◽  
Joshua P. Klein ◽  
Shamik Bhattacharyya
Keyword(s):  
Medical Center ◽  
Case Reports ◽  
Academic Medical Center ◽  
Autoimmune Encephalitis ◽  
Final Diagnosis ◽  
Inpatient Service ◽  
Antibody Testing ◽  
Academic Medical ◽  
Positive Antibody ◽  
Paraneoplastic Antibody

Objective: To determine the frequency of autoimmune antibody testing in an inpatient neurology setting and its influence on immunotherapy use on an inpatient neurology service. Methods: A retrospective descriptive cohort study of patients admitted to the neurology inpatient service at a large tertiary academic medical center who had autoimmune and/or paraneoplastic antibody testing performed between 10/1/2017 and 10/1/2018. Characteristics of patients’ initial clinical presentation, antibody testing results, test timing in relation to initiating immunotherapy, and final diagnosis using consensus criteria were extracted and analyzed. Case reports of patients with positive antibody panels are presented. Results: Of 1,604 patients, 50 patients (3.1%) had an antibody panel sent. Tests resulted after an average of 17 days (range 7-27). The most common clinical presenting symptom in those with a panel sent was encephalopathy. There were 5 (10%) positive serum panels and no positive CSF panels. Only one of these 5 patients had autoimmune encephalitis and was treated with immunotherapy. Of those with negative serum and CSF panels, 15 were treated acutely with empiric immunotherapy and the remainder with supportive care. Of those treated with immunotherapy, 14/15 (93%) were treated before the panel tests resulted. Four patients who had negative panels but were empirically treated met consensus criteria for an autoimmune-mediated neurologic process. Conclusion: Our study suggests that the results of antibody testing did not influence inpatient neurologists’ decision to treat with immunotherapy as most treatments began prior to final results being available.

Antibody to CCDC104 is associated with a paraneoplastic antibody to CDR2 (anti-Yo)

2009 ◽  
Vol 59 (2) ◽  
pp. 231-237 ◽  
Author(s):  
Cecilie Totland ◽  
Geir Bredholt ◽  
Mette Haugen ◽  
Bjørn Ivar Haukanes ◽  
Christian A. Vedeler
Keyword(s):  
Paraneoplastic Antibody

scholarly journals Into a Shaking Limbo: Case Report of a Nonneoplastic Limbic Encephalitis with Faciobrachial Dystonic Seizures and Parkinsonism

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Vijay Renga
Keyword(s):  
Case Report ◽  
Early Identification ◽  
Limbic Encephalitis ◽  
Clinical Course ◽  
Rare Condition ◽  
Paraneoplastic Antibody

This case report describes a rare but classic presentation of a non-paraneoplastic, antibody-mediated limbic encephalitis. The clinical course did put us in a limbo as it evolved from seizure to Parkinsonism and then from metastasis to stroke, before it finally announced itself by its pathognomonic finding. Knowledge of this rare condition is important as early identification and treatment can change the course.

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