scholarly journals Estrogen Activity Induction

2020 ◽  
Author(s):  
Keyword(s):  
Estrogen Activity ◽  
Activity Induction

scholarly journals Polymorphisms inHSD17B1: Early Onset and Increased Risk of Alzheimer’s Disease in Women with Down Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Joseph H. Lee ◽  
Susan Gurney ◽  
Deborah Pang ◽  
Alexis Temkin ◽  
Naeun Park ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Age At Onset ◽  
Nucleotide Polymorphisms ◽  
Risk Alleles ◽  
Increased Risk ◽  
Estrogen Activity ◽  
Intron 4

Background/Aims. Genetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). In women with Down syndrome, we examined the relation of polymorphisms in hydroxysteroid-17beta-dehydrogenase (HSD17B1) to age at onset and risk of AD.HSD17B1encodes the enzyme 17β-hydroxysteroid dehydrogenase (HSD1), which catalyzes the conversion of estrone to estradiol.Methods. Two hundred and thirty-eight women with DS, nondemented at baseline, 31–78 years of age, were followed at 14–18-month intervals for 4.5 years. Women were genotyped for 5 haplotype-tagging single-nucleotide polymorphisms (SNPs) in theHSD17B1gene region, and their association with incident AD was examined.Results. Age at onset was earlier, and risk of AD was elevated from two- to threefold among women homozygous for the minor allele at 3 SNPs in intron 4 (rs676387), exon 6 (rs605059), and exon 4 inCOASY(rs598126). Carriers of the haplotype TCC, based on the risk alleles for these three SNPs, had an almost twofold increased risk of developing AD (hazard ratio = 1.8, 95% CI, 1.1–3.1).Conclusion. These findings support experimental and clinical studies of the neuroprotective role of estrogen.

A Cellular Model for the Study of Estrogen Activity in Cells of Neural Origin

1997 ◽  
pp. 523-528
Author(s):  
Adriana Maggi ◽  
Paola Agrati ◽  
Cesare Patrone ◽  
Sabrina Santagati ◽  
Martine Gamier ◽  
...  
Keyword(s):  
Cellular Model ◽  
Estrogen Activity ◽  
Neural Origin ◽  
In Cells

An Ultramicro Method for the Estimation of Plasma Cholesterol

1962 ◽  
Vol 8 (2) ◽  
pp. 105-112 ◽  
Author(s):  
G S Duboff ◽  
W W Stevenson
Keyword(s):  
Menstrual Cycle ◽  
Total Cholesterol ◽  
Plasma Cholesterol ◽  
Physical Conditioning ◽  
Cholesterol Levels ◽  
Estrogen Activity ◽  
Finger Tip ◽  
Consequent Increase ◽  
Similar Decrease

Abstract A procedure is outlined for the ultramicro determination of total cholesterol that gives results in excellent agreement with classic methods. The determination requires 40 µl. of plasma obtained from a finger-tip puncture and special handling of precipitated proteins. By the use of the described procedure plasma cholesterol levels have been estimated 4 times daily over a period of 8 weeks in young men undergoing rigorous physical training and 3 times daily in women during the menstrual cycle. A striking fall in total plasma cholesterol was observed in men following physical conditioning in contrast to controls, and a similar decrease was observed in women with normal menstrual cycles in contrast to women with an anovulatory menses. It is suggested that the total cholesterol decrease in the female coincides with the phase in the menstrual cycle when estrogen activity is maximal and that the lowering of total cholesterol in men, following physical conditioning, may be due to an increased production of endogenous androgens with a consequent increase in conversion of these steroids to estrogens.

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