scholarly journals Azurophilic Granule

2020 ◽  
Author(s):  
Keyword(s):  
Azurophilic Granule

The Rho-related GTPase Rac2 is essential for regulation of neutrophil azurophilic granule release

2003 ◽  
Vol 111 (2) ◽  
pp. S113
Author(s):  
P. Lacy ◽  
D. Abdel Latif ◽  
M. Steward ◽  
D. Macdonald ◽  
G.A. Francis ◽  
...  
Keyword(s):  
Azurophilic Granule ◽  
Granule Release

scholarly journals Neutrophil azurophilic granule exocytosis is primed by TNF-α and partially regulated by NADPH oxidase

2016 ◽  
Vol 22 (8) ◽  
pp. 635-646 ◽  
Author(s):  
Renee M Potera ◽  
Melissa J Jensen ◽  
Brieanna M Hilkin ◽  
Gina K South ◽  
Jessica S Hook ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Tissue Damage ◽  
Chronic Inflammatory Disease ◽  
Host Tissue ◽  
Ros Generation ◽  
Oxygen Species ◽  
Granule Exocytosis ◽  
Azurophilic Granule ◽  
Tnf Α

Neutrophil (polymorphonuclear leukocyte) activation with release of granule contents plays an important role in the pathogenesis of acute lung injury, prompting clinical trials of inhibitors of neutrophil elastase. Despite mounting evidence for neutrophil-mediated host tissue damage in a variety of disease processes, mechanisms regulating azurophilic granule exocytosis at the plasma membrane, and thus release of elastase and other proteases, are poorly characterized. We hypothesized that azurophilic granule exocytosis would be enhanced under priming conditions similar to those seen during acute inflammatory events and during chronic inflammatory disease, and selected the cytokine TNF-α to model this in vitro. Neutrophils stimulated with TNF-α alone elicited intracellular reactive oxygen species (ROS) generation and mobilization of secretory vesicles, specific, and gelatinase granules. p38 and ERK1/2 MAPK were involved in these components of priming. TNF-α priming alone did not mobilize azurophilic granules to the cell surface, but did markedly increase elastase release into the extracellular space in response to secondary stimulation with N-formyl-Met-Leu-Phe (fMLF). Priming of fMLF-stimulated elastase release was further augmented in the absence of NADPH oxidase-derived ROS. Our findings provide a mechanism for host tissue damage during neutrophil-mediated inflammation and suggest a novel anti-inflammatory role for the NADPH oxidase.

scholarly journals Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent Mechanisms

Traffic ◽  
2010 ◽  
Vol 11 (4) ◽  
pp. 533-547 ◽  
Author(s):  
Jennifer L. Johnson ◽  
Agnieszka A. Brzezinska ◽  
Tanya Tolmachova ◽  
Daniela B. Munafo ◽  
Beverly A. Ellis ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Oxidase Activity ◽  
Granule Exocytosis ◽  
Nadph Oxidase Activity ◽  
Azurophilic Granule

Release of azurophilic granule contents in fMLP-stimulated neutrophils requires two activation signals, one of which is a rise in cytosolic free Ca2+

1991 ◽  
Vol 3 (6) ◽  
pp. 625-633 ◽  
Author(s):  
Hans W.M. Niessen ◽  
Taco W. Kuijpers ◽  
Dirk Roos ◽  
Arthur J. Verhoeven
Keyword(s):  
Azurophilic Granule

scholarly journals Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis

2017 ◽  
Vol 7 ◽  
Author(s):  
Jennifer L. Johnson ◽  
Mahalakshmi Ramadass ◽  
Ariela Haimovich ◽  
Matthew D. McGeough ◽  
Jinzhong Zhang ◽  
...  
Keyword(s):  
Granule Exocytosis ◽  
Azurophilic Granule

Transloation of slexon the azurophilic granule membrane to the plasma membrane in activated human neutrophils

2000 ◽  
Vol 49 (2) ◽  
pp. 359-370 ◽  
Author(s):  
H. Suzuki ◽  
S. Yokimizo ◽  
S. Wakamoto ◽  
K. Watanabe ◽  
K. Hirose ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Human Neutrophils ◽  
Azurophilic Granule ◽  
Granule Membrane

Differential distribution of distinct forms of myeloperoxidase in different azurophilic granule subpopulations from human neutrophils

1983 ◽  
Vol 114 (1) ◽  
pp. 296-303 ◽  
Author(s):  
Joseph M. Kinkade ◽  
Stephen O. Pember ◽  
Katherine C. Barnes ◽  
Raymond Shapira ◽  
John K. Spitznagel ◽  
...  
Keyword(s):  
Human Neutrophils ◽  
Differential Distribution ◽  
Azurophilic Granule
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