scholarly journals Erythrocyte Ghost Count

2020 ◽  
Author(s):  
Keyword(s):  
Erythrocyte Ghost

Inhibition of Copper-Associated Erythrocyte Ghost Membrane Lipid Peroxidation by Hepatic Cytosolic Low Molecular Weight Proteins

1991 ◽  
Vol 19 (3) ◽  
pp. 206-213
Author(s):  
Bruce L. Homer ◽  
Kenneth R. Pierce ◽  
Charles H. Bridges ◽  
James E. Womack ◽  
Blair A. Sowa ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Molecular Weight ◽  
Membrane Lipid ◽  
Erythrocyte Ghost ◽  
Low Molecular Weight ◽  
Membrane Lipid Peroxidation ◽  
Low Molecular Weight Proteins

Inhibition Kinetics of 16 Organophosphorus Pesticides or Their Active Metabolites on Erythrocyte Acetylcholinesterase from Humans and Rats

2021 ◽  
Author(s):  
Edward C Meek ◽  
Richard Reiss ◽  
J Allen Crow ◽  
Janice E Chambers
Keyword(s):  
Kinetic Parameters ◽  
Organophosphorus Pesticides ◽  
Erythrocyte Ghost ◽  
Inhibition Kinetics ◽  
Active Metabolites ◽  
Adult Rats ◽  
Resultant Data ◽  
Wide Range ◽  
High Level ◽  
Pooled Samples

Abstract Inhibition kinetics assays were conducted with 16 commercial organophosphate (OP) pesticides or their metabolites on acetylcholinesterase (AChE) in erythrocyte “ghost” preparations from 18 individual humans (both sexes; adults, juveniles and cord blood samples; mixed races/ethnicities) and pooled samples from adult rats (both sexes). A well established spectrophotometric assay using acetylthiocholine as substrate and a chromogen was employed. The kinetic parameters bimolecular rate constant (ki), dissociation constant (KI) and phosphorylation constant (kp) were calculated for each compound. As expected, a wide range of potencies were displayed among the tested compounds. Statistical analysis of the resultant data indicated no differences in sex, age or race/ethnicity among the human samples that are unexpected based on chance (4.2% statistically significant out of 48 parameters calculated) and no differences between the sexes in rats. The bimolecular rate constants for 10 of the compounds were not statistically different between rats and humans. The data indicate that, consistent with the high level of conservation of AChE among species and the fact that AChE at different locations within a species arises from the same gene, the inhibition kinetic parameters calculated from rat erythrocyte ghost preparations should be useful in estimating potencies of OP compounds on target AChE in humans. Additionally the data indicate that differences in sensitivities among individual humans were not apparent. Impact Statement: These data are expected to be useful in consideration of the intraspecies and interspecies uncertainty factors in OP pesticide risk assessment.

scholarly journals Erythrocyte ghost-mediated gene delivery for prolonged and blood-targeted expression

Gene Therapy ◽  
2004 ◽  
Vol 11 (5) ◽  
pp. 492-496 ◽  
Author(s):  
H-M Byun ◽  
D Suh ◽  
H Yoon ◽  
JM Kim ◽  
H-G Choi ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Erythrocyte Ghost ◽  
Targeted Expression

The role of spectrin in erythrocyte ghost endocytosis

1978 ◽  
Vol 81 (4) ◽  
pp. 1153-1161 ◽  
Author(s):  
Britta Hardy ◽  
Stanley L. Schrier
Keyword(s):  
Erythrocyte Ghost
Sign in / Sign up

Export Citation Format

Share Document