scholarly journals Small Intestinal Enteropathy-Associated T-Cell Lymphoma

2020 ◽  
Author(s):  
2007 ◽  
Vol 135 (1-2) ◽  
pp. 80-84
Author(s):  
Milena Bakrac ◽  
Branka Bonaci-Nikolic ◽  
Natasa Colovic ◽  
Sanja Simic-Ogrizovic ◽  
Miodrag Krstic ◽  
...  

Enteropathy associated T-cell lymphoma (EATCL) is a high grade, pleomorphic peripheral T-cell lymphoma with usually cytotoxic phenotype. This is a case report of three patients with EATCL. The first patient was 50 year-old woman with four year history of gluten sensitive enteropathy (GSE). Diagnosis of lymphoma was confirmed after the resection of the jejunum (small intestine obstruction). Pathohistological (PAS, Reticulin, Giemsa) and immunohistochemical (anti-LCA, anti-CD20, anti- CD45RO, anti-CD3) methods revealed the diagnosis of EATCL: CD45RO+, CD3+. After the third cycle of chemotherapy, the disease progressed with massive lung infiltration. Patient died due to complications of bone marrow aplasia. The second patient was 23 year-old woman with long earlier history of GSE. She presented with the acute renal failure. According to established diagnosis of tubulointerstitial nephritis, she was treated with pulse doses of steroid therapy. After temporary improvement, she had dissemination of the disease. On MRI, small intestinal wall was thickened, and abdominal lymph nodes were enlarged with extraluminal compression of common bile duct. Laparotomy with mesenterial lymph node biopsy and consecutive pathohistological and immunohistochemical analyses revealed the diagnosis of EATCL. The patient received chemotherapy, but she died with signs of pulmonary embolization. The third patient was 53 year-old woman without previous history of GSE. Diagnosis of EATCL was revealed after the resection of jejunum because of small intestinal obstruction. She received two cycles of chemotherapy, but she died with signs of disease progression. IgA antiendomysial antibodies were detected in the serum of all patients. The overall survival of patients was 7 months. The possibility of lymphoma rising in patients with clinical progression of GSE despite gluten free diet must be kept in mind.


2007 ◽  
Vol 451 (6) ◽  
pp. 1091-1093 ◽  
Author(s):  
Magali Svrcek ◽  
Laurent Garderet ◽  
Virginie Sebbagh ◽  
Michelle Rosenzwajg ◽  
Yann Parc ◽  
...  

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e68343 ◽  
Author(s):  
Elizabeth Margolskee ◽  
Vaidehi Jobanputra ◽  
Suzanne K. Lewis ◽  
Bachir Alobeid ◽  
Peter H. R. Green ◽  
...  

2014 ◽  
Vol 12 (4) ◽  
pp. 599-608.e1 ◽  
Author(s):  
Georgia Malamut ◽  
Bertrand Meresse ◽  
Sophie Kaltenbach ◽  
Coralie Derrieux ◽  
Virginie Verkarre ◽  
...  

2021 ◽  
pp. 312-322
Author(s):  
Yasuhiro Aoki ◽  
Tomohisa Sujino ◽  
Kaoru Takabayashi ◽  
Makoto Mutakuchi ◽  
Katsura Emoto ◽  
...  

A 77-year-old female who had an acute severe abdominal pain was taken to the emergency room in the previous hospital. CT scans showed jejunum and ileum wall thickening and fatty deposits around the small intestinal tract, and gastrointestinal perforation could not be ruled out. By using single anal and oral balloon endoscopy, we observed mild edema with petechial erythema, shallow erosions with edematous mucosa and ulcers with surrounded disrupted villous structures at the jejunum and ileum. Histological analysis revealed atypical lymphocytes infiltrating the small intestinal mucosa demonstrating intraepithelial lymphocytosis. Immunohistochemical staining revealed that CD3, CD7, and CD56 staining was positive, and CD4, CD5, and CD8 staining was negative in infiltrated lymphocytes. We made the diagnosis of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) with the combination of HE staining and IHC. PET-CT showed abnormal uptake in irregular wall thickening of the small intestine, lymph nodes, ribs, spine and pelvic bone. She was treated with chemotherapy (etoposide, prednisolone, oncovin, cyclophosphamide, hydroxydaunorubicin) and is still alive 1 year after the diagnosis. We reported the various endoscopic findings in the same MEITL patient by using single balloon endoscopy. We also summarized endoscopic characteristics of MEITL patients.


2013 ◽  
Vol 16 (2) ◽  
pp. 89-98 ◽  
Author(s):  
Lise A Daniaux ◽  
Michele P Laurenson ◽  
Stanley L Marks ◽  
Peter F Moore ◽  
Sandra L Taylor ◽  
...  

Cancer ◽  
1994 ◽  
Vol 73 (4) ◽  
pp. 1286-1291 ◽  
Author(s):  
Franck Carbonnel ◽  
Anne Lavergne ◽  
Bernard Messing ◽  
Andreas Tsapis ◽  
Roland Berger ◽  
...  

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