scholarly journals IL1B Gene

2020 ◽  
Author(s):  
Keyword(s):  
Il1b Gene

IL1A and IL1B gene polymorphisms and keratoconus susceptibility: evidence from an updated meta-analysis

2021 ◽  
pp. 1-11
Author(s):  
Mahdiyeh Harati-Sadegh ◽  
Saman Sargazi ◽  
Milad Khorasani ◽  
Alireza Ansari-Moghaddam ◽  
Shekoufeh Mirinejad ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Il1b Gene

scholarly journals THE ROLE OF INTERLEUKIN 1β GENE POLYMORPHISM IN DEVELOPMENT OF PREDOMINANTY SENSORY CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY

2019 ◽  
Vol 21 (1) ◽  
pp. 141-148
Author(s):  
T. E. Popova ◽  
N. A. Shnayder ◽  
M. M. Petrova ◽  
A. A. Tappakhov
Keyword(s):  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Study Groups ◽  
Krasnoyarsk Region ◽  
Genotype Frequencies ◽  
Increased Risk ◽  
Significant Difference ◽  
Risk Of Disease ◽  
T Locus ◽  
Il1b Gene

The aim of the present study was a search for associations between the polymorphic allelic variants 3954 C>T (rs1143644) and -511C>T (rs16944) of IL1B gene in the patients with sensory predominant chronic inflammatory demyelinating polyneuropathies (SP-CIDP) from Krasnoyarsk Region and the Sakha (Yakutia) Republic. A total of 95 people were examined, having been divided into 2 groups according to their residence. The first group consisted of 42 patients living in the Sakha (Yakutia) Republic. The second group included 53 patients living in the Krasnoyarsk Region. It was revealed that the carriers of homozygous CC genotype in the 3954C>T locus were more often detected in patients from the Sakha (Yakutia) Republic, and the carriage of TT genotype is found exclusively in the patients from Krasnoyarsk Region. When comparing the different genotype frequencies in the -511CT locus, we did not reveal any statistically significant differences between the two groups of patients. Presence of the CC genotype of the 3954C>T locus was associated with a significantly increased risk of disease in the patients from Sakha (Yakutia) Republic, while carrying CT and TT genotypes at the locus 3954C>T and the TT genotype at the locus -511C>T, is associated with increased risk disorder among patients of the Krasnoyarsk Region. The frequency of carriage of various genotypes in the 3954C>T and -511C>T loci of the IL1B gene was prevalent among the patients from the Sakha (Yakutia) Republic, the association of genotypes of CC/CT prevailed in patients from the Krasnoyarsk Region (p = 0.005), as well as prevalence of CC/CC and CC/CT (p = 0.023). However, there was no statistically significant difference in occurrence of individual genotypes between the two study groups. When analyzing the carrier frequency of high-producing alleles of 3954C and -511C in patients with SP-CIDP, it was shown that they were significantly more common among patients from the Sakha (Yakutia) Republic and patients from the Krasnoyarsk Region than the low-producing 3954T and -511T alleles. Moreover, the 3954C allele was more often found in the Yakut group (p = 0.001), and in the -511C allele for the Krasnoyarsk group of patients (p = 0.05). The presence of 3954C and -511C alleles increases the risk of SP-CIDP development in patients from the Sakha (Yakutia) Republic, as well as carriage of 3954T allele in patients from the Krasnoyarsk Region.

Low bone mass in celiac disease is associated with an allelic variation in the IL1B gene

2003 ◽  
Vol 124 (4) ◽  
pp. A15
Author(s):  
Maria L. Moreno ◽  
Laura Murillo ◽  
Horacio Vazquez ◽  
Roberto M. Mazure ◽  
Alejandra Chemavsky ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Bone Mass ◽  
Allelic Variation ◽  
Low Bone Mass ◽  
Il1b Gene

Abstract 1343: Association between IL1B gene haplotypes and colorectal cancer risk in Colombian populations: a case-control study.

2013 ◽  
Author(s):  
María Carolina Sanabria-Salas ◽  
Gustavo Hernández-Suárez ◽  
Adriana Umaña ◽  
Martha Lucía Serrano López ◽  
Myriam Y. Sánchez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Colorectal Cancer Risk ◽  
Control Study ◽  
Il1b Gene

The Interleukin 1 Beta (IL1B) Gene Is Associated with Failure to Achieve Remission and Impaired Emotion Processing in Major Depression

2010 ◽  
Vol 67 (6) ◽  
pp. 543-549 ◽  
Author(s):  
Bernhard T. Baune ◽  
Udo Dannlowski ◽  
Katharina Domschke ◽  
Debbie G.A. Janssen ◽  
Margaret A. Jordan ◽  
...  
Keyword(s):  
Major Depression ◽  
Interleukin 1 ◽  
Emotion Processing ◽  
Interleukin 1 Beta ◽  
Il1b Gene

An Interleukin-1 beta (IL1B) haplotype linked with psychosis transition is associated with IL1B gene expression and brain structure

2019 ◽  
Vol 204 ◽  
pp. 201-205 ◽  
Author(s):  
Md Shaki Mostaid ◽  
Stefanos Dimitrakopoulos ◽  
Cassandra Wannan ◽  
Vanessa Cropley ◽  
Cynthia Shannon Weickert ◽  
...  
Keyword(s):  
Gene Expression ◽  
Brain Structure ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Il1b Gene

scholarly journals Association between IL1A and IL1B polymorphisms and primary open angle glaucoma in a Brazilian population

2018 ◽  
Vol 243 (13) ◽  
pp. 1083-1091 ◽  
Author(s):  
Mariana B Oliveira ◽  
José Paulo C de Vasconcellos ◽  
Galina Ananina ◽  
Vital P Costa ◽  
Mônica B de Melo
Keyword(s):  
Linkage Disequilibrium ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Strong Linkage Disequilibrium ◽  
Risk Haplotype ◽  
Open Angle ◽  
Single Nucleotide ◽  
Individual Snps ◽  
Significant Difference ◽  
Il1b Gene

The aim of this study was to investigate the association of five polymorphisms in the IL1A and IL1B genes in Brazilian patients with primary open angle glaucoma (POAG). A case–control study, including 214 unrelated POAG patients and 187 healthy individuals, was conducted to evaluate the frequency of polymorphisms in the IL1A and IL1B genes. Ophthalmic evaluation was performed and genomic DNA was obtained from all participants. Five single nucleotide polymorphisms (SNPs): IL1A (–889C/T: rs1800587:C > T, +4845G/T:rs17561G>T) and IL1B (–31C/T:rs1143627:T > C, –511C/T:rs16944C>T and +3954C/T:rs1143634:C > T) were genotyped through direct sequencing. The association of individual SNPs was tested using logistic regression. There was an association between the –31C/T and –511 C/T polymorphisms in the IL1B gene with POAG (p = 0.002 and p = 0.009, respectively). High linkage disequilibrium was observed between the –31C/T and –511C/T polymorphisms. The statistical analysis showed that the T/C haplotype (–31/–511) in the IL1B gene is more frequent in controls (p = 0.011) and the C/T haplotype (–31/–511) is more common in POAG patients (p = 0.018). Among POAG cases, the genotypic distribution of the –31C/T and –511 C/T SNPs was significantly different in patients who underwent anti-glaucomatous surgery compared to patients without surgery (p = 0.016 and 0.023, respectively). There was no statistically significant difference for the remaining SNPs between POAG patients and controls. In conclusion, the C allele of the –31C/T and the T allele of the –511C/T polymorphisms in the IL1B gene may represent a “risk haplotype” for the development of POAG in Brazilian individuals. Further studies with larger cohorts of patients are necessary to substantiate these findings. Impact statement This study is the first, according to our knowledge, to show the association between glaucoma and the functional –31C/T single nucleotide polymorphism. We provide evidence indicating that homozygotes CC at –31C/T and TT at –511 C/T of IL1B are at risk for glaucoma. We also demonstrated that these polymorphisms are in strong linkage disequilibrium (LD). Increasing evidence support the role of inflammation in glaucoma and this study is an important result that reinforces these findings. How IL-1 signaling influences the triggering and pathogenesis of glaucoma remains to be investigated. Greater understanding of the mechanisms leading to glaucoma will provide the development of new management strategies that target the primary disease lesion and maybe the discovery of new treatments.

scholarly journals Polymorphism of Interleukin-1 Gene Cluster in Polish Patients with Acute Coronary Syndrome

2021 ◽  
Vol 10 (5) ◽  
pp. 990
Author(s):  
Tomasz Rechciński ◽  
Bożena Szymańska ◽  
Karina Wierzbowska-Drabik ◽  
Magdalena Chmiela ◽  
Agnieszka Matusiak ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Gene Cluster ◽  
Coronary Atherosclerosis ◽  
Age Of Onset ◽  
Interleukin 1 ◽  
Experimental Studies ◽  
Common Variants ◽  
Coronary Syndrome ◽  
The Impact ◽  
Il1b Gene

Background and objectives: Some experimental studies demonstrated adverse modulation of atherothrombosis by interleukin-1beta (IL-1b). To assess the relationship between the five most common variants of three polymorphisms of the IL1b gene cluster and the complexity of coronary atherosclerosis expressed in Gensini Score (GS), and the age of onset of the first acute coronary syndrome (ACS), we assessed the patients (pts) hospitalized due to ACS in this aspect. Materials and Methods: 250 individuals were included. The single nucleotide polymorphisms of IL1b gene: transition T/C at -31 position, C/T at -511, and those of IL1 receptor antagonist gene (IL1RN)—variable number of tandem repeats allele 1, 2, 3, or 4—were determined by PCR. GS was calculated from the coronary angiogram performed at the index ACS. The impact of the presence of T or C and allele 1 to 4 at the investigated loci on the mean GS, GS greater than 40, mean age of onset of ACS, and the fraction of pts over 60 years of age at ACS were compared between the five most common genotype variants. Results: The five most common variants were present in 203 pts (81.2%). Patients with pair 22 in ILRN had the lowest rate and those with pair 12 had the highest rate of ACS before 60 years of age (29.4 vs. 67.8%; p = 0.004). GS > 40 entailed an eight-fold increase of risk, as observed when pts with one T allele at locus -31 were compared with carriers of 2 or no T allele at this locus: OR 8.73 [CI95 4.26–70.99] p = 0.04. Conclusion: Interleukin-1 beta is subject to frequent genetic variability and our results show a potential relationship of this polymorphism with the extent of coronary atherosclerosis and age at the first ACS.

scholarly journals A functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma

2012 ◽  
Vol 158 (4) ◽  
pp. 515-518 ◽  
Author(s):  
Annette J. Vangsted ◽  
Kaspar R. Nielsen ◽  
Tobias W. Klausen ◽  
Einar Haukaas ◽  
Anne Tjønneland ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Promoter Region ◽  
Functional Polymorphism ◽  
Il1b Gene
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