scholarly journals Caspase Gene

2020 ◽  
Author(s):  
Keyword(s):  
Caspase Gene

scholarly journals Germline Cell Death Is Inhibited byP-Element Insertions Disrupting thedcp-1/pitaNested Gene Pair in Drosophila

Genetics ◽  
2003 ◽  
Vol 165 (4) ◽  
pp. 1881-1888 ◽  
Author(s):  
Bonni Laundrie ◽  
Jeanne S Peterson ◽  
Jason S Baum ◽  
Jeffrey C Chang ◽  
Dana Fileppo ◽  
...  
Keyword(s):  
Cell Death ◽  
Nurse Cell ◽  
Zinc Finger Protein ◽  
P Element ◽  
Germline Cell ◽  
Developmentally Regulated ◽  
Developmental Abnormalities ◽  
Egg Chambers ◽  
Caspase Gene ◽  
Active Caspase

AbstractGermline cell death in Drosophila oogenesis is controlled by distinct signals. The death of nurse cells in late oogenesis is developmentally regulated, whereas the death of egg chambers during mid-oogenesis is induced by environmental stress or developmental abnormalities. P-element insertions in the caspase gene dcp-1 disrupt both dcp-1 and the outlying gene, pita, leading to lethality and defective nurse cell death in late oogenesis. By isolating single mutations in the two genes, we have found that the loss of both genes contributes to this ovary phenotype. Mutants of pita, which encodes a C2H2 zinc-finger protein, are homozygous lethal and show dumpless egg chambers and premature nurse cell death in germline clones. Early nurse cell death is not observed in the dcp-1/pita double mutants, suggesting that dcp-1+ activity is required for the mid-oogenesis cell death seen in pita mutants. dcp-1 mutants are viable and nurse cell death in late oogenesis occurs normally. However, starvation-induced germline cell death during mid-oogenesis is blocked, leading to a reduction and inappropriate nuclear localization of the active caspase Drice. These findings suggest that the combinatorial loss of pita and dcp-1 leads to the increased survival of abnormal egg chambers in mutants bearing the P-element alleles and that dcp-1 is essential for cell death during mid-oogenesis.

scholarly journals Contribution of the Caspase Gene Sequence Diversification to the Specifically Antiviral Defense in Invertebrate

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e24955 ◽  
Author(s):  
Bin Zhi ◽  
Lei Wang ◽  
Guangyi Wang ◽  
Xiaobo Zhang
Keyword(s):  
Gene Sequence ◽  
Antiviral Defense ◽  
Caspase Gene

scholarly journals Daxx Silencing Sensitizes Cells to Multiple Apoptotic Pathways

2003 ◽  
Vol 23 (20) ◽  
pp. 7108-7121 ◽  
Author(s):  
Liuh-Yow Chen ◽  
J. Don Chen
Keyword(s):  
Gene Expression ◽  
Transcriptional Repression ◽  
Mammalian Cells ◽  
Death Receptor ◽  
Kinase Activation ◽  
Transient Overexpression ◽  
Apoptotic Pathways ◽  
Induced Apoptosis ◽  
Caspase Gene ◽  
Interfering Rna

ABSTRACT Daxx is a nuclear protein involved in apoptosis and transcriptional repression, and it interacts with the death receptor Fas, promyelocytic leukemia protein (PML), and several transcriptional repressors. The function of Daxx in apoptosis is controversial because opposite results were obtained in transient overexpression and genetic knockout studies. Furthermore, the roles of PML and transcriptional repression in Daxx-regulated apoptosis are currently unknown. In this study, we investigated the role of Daxx in Fas- and stress-induced apoptosis by small interfering RNA-mediated Daxx silencing in mammalian cells. Daxx silencing had no apparent cytotoxic effects on mammalian cells within 72 h. Intriguingly, Daxx silencing strongly sensitized cells to Fas- and stress-induced apoptosis, which was accompanied by caspase activation, cytochrome c release, and Jun N-terminal kinase activation. Consistently, endogenous Daxx was degraded rapidly upon induction of apoptosis by stress or anti-Fas antibody. Finally, PML silencing had no effect on Daxx silencing-mediated apoptotic events, while caspase gene expression was upregulated in the absence of Daxx. These data strongly suggest that Daxx may inhibit Fas and stress-mediated apoptosis by suppressing proapoptotic gene expression outside of PML domains.

Knockdown of Actin and Caspase Gene Expression by RNA Interference in the Symbiotic Anemone Aiptasia pallida

2007 ◽  
Vol 212 (3) ◽  
pp. 250-258 ◽  
Author(s):  
Simon R. Dunn ◽  
Wendy S. Phillips ◽  
Douglas R. Green ◽  
Virginia M. Weis
Keyword(s):  
Gene Expression ◽  
Rna Interference ◽  
Aiptasia Pallida ◽  
Caspase Gene

The responsive expression of a caspase gene in Chinese shrimp Fenneropenaeus chinensis against pH stress

2011 ◽  
Vol 42 (8) ◽  
pp. 1214-1230 ◽  
Author(s):  
Yun Wang ◽  
Jian Li ◽  
Ping Liu ◽  
Jitao Li ◽  
Zhe Zhang ◽  
...  
Keyword(s):  
Fenneropenaeus Chinensis ◽  
Chinese Shrimp ◽  
Ph Stress ◽  
Caspase Gene

STAT1 und Caspase gene silencing als wichtiger Mechanismus intrinsischer Chemoresistenz des Pankreaskarzinoms

2007 ◽  
Vol 45 (08) ◽  
Author(s):  
S Sebens ◽  
V Werbing ◽  
O Ammerpohl ◽  
M Witt ◽  
M Großmann ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Caspase Gene

scholarly journals Caspase Gene Expression in the Brain as a Function of the Clinical Progression of Alzheimer Disease

2003 ◽  
Vol 60 (3) ◽  
pp. 369 ◽  
Author(s):  
Patrick N. Pompl ◽  
Shrishailam Yemul ◽  
Zhongmin Xiang ◽  
Lap Ho ◽  
Varham Haroutunian ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer Disease ◽  
Clinical Progression ◽  
Caspase Gene ◽  
The Brain
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