scholarly journals Ampicillin Sodium/Sulbactam Sodium

2020 ◽  
Author(s):  
Keyword(s):  
Ampicillin Sodium

Stability of Antibiotic Admixtures Frozen in Minibags

1977 ◽  
Vol 11 (9) ◽  
pp. 542-548 ◽  
Author(s):  
B. A. Dinel ◽  
D. L. Ayotte ◽  
R. J. Behme ◽  
B. L. Black ◽  
J. L. Whitby
Keyword(s):  
Significant Loss ◽  
Penicillin G ◽  
Freezing And Thawing ◽  
Ampicillin Sodium ◽  
Gentamicin Sulfate ◽  
Cefazolin Sodium ◽  
The Stability ◽  
Diffusion Assay ◽  
Percent Normal ◽  
Gel Diffusion

This study investigated the stability of frozen antibiotic admixtures prepared in minibags containing 50 ml of 0.9 percent normal saline and 5 percent dextrose in water. The minibag antibiotic admixtures studied were ampicillin sodium 1 g, carbenicillin disodium 2 g, cephalothin sodium 1 g, cloxacillin sodium 1 g, cefazolin sodium 1 g, gentamicin sulfate 50 mg, penicillin G potassium 2 million units, erythromycin gluceptate 500 mg and rolitetracycline base 275 mg. The stability of each antibiotic was determined by a quantitative microbiological agar gel diffusion assay. The minibags were frozen within an hour of the admixtures being prepared. During storage in a freezer at −20 °C (–4 °F), the minibags were placed in a storage module to reduce unnecessary handling. Assays were conducted on minibags which had been frozen for 24 hours, 7 days and 30 days. All thawed samples were re-assayed after storage at 5–6 °C (21–23 °F) for 21 hours. The results of the study indicated that minibag admixtures of carbenicillin disodium, cephalothin sodium, cloxacillin sodium, gentamicin sulfate, penicillin G potassium, erythromycin gluceptate, cefazolin sodium and rolitetracycline base in the concentrations tested can be frozen for 30 days without a significant loss in activity. These antibiotics were also stable when thawed and stored at 5–6 °C (21–23 °F) for 21 hours. Ampicillin sodium admixtures were not stable when frozen. A handling procedure for the frozen minibags is described. Specific recommendations are also included for freezing and thawing the minibags and in the use of a specially designed storage module.

scholarly journals Formulation development and in vitro and in vivo evaluation of membrane-moderated transdermal systems of ampicillin sodium in ethanol: pH 4.7 buffer solvent system

2007 ◽  
Vol 8 (1) ◽  
pp. E50-E55 ◽  
Author(s):  
Janardhanan Bagyalakshmi ◽  
Ramachandra Purapu Vamsikrishna ◽  
Rajappan Manavalan ◽  
Thengungal Kochupappy Ravi ◽  
Probal Kumar Manna
Keyword(s):  
Solvent System ◽  
Formulation Development ◽  
In Vivo Evaluation ◽  
Ampicillin Sodium
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