scholarly journals Hematoporphyrin Derivative

2020 ◽  
Author(s):  
Keyword(s):  
Hematoporphyrin Derivative

Hematoporphyrin Derivative Photoradiation Therapy Applied in Gynecology

1986 ◽  
Vol 2 (1) ◽  
pp. 53-58 ◽  
Author(s):  
HELMUT F. SCHELLHAS ◽  
DAVID F. SCHNEIDER
Keyword(s):  
Hematoporphyrin Derivative

Exposure (dose) tables for hematoporphyrin derivative photoradiation therapy

1984 ◽  
Vol 4 (1) ◽  
pp. 107-131 ◽  
Author(s):  
Michael W. Berns ◽  
Gregory S. Berns ◽  
Joan Coffey ◽  
Alan G. Wile
Keyword(s):  
Exposure Dose ◽  
Hematoporphyrin Derivative

Response of psoriasis to red laser light (630 nm) following systemic injection of hematoporphyrin derivative

1984 ◽  
Vol 4 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Michael W. Berns ◽  
Joan Coffey ◽  
Alan Wile ◽  
Mark Rettenmaier ◽  
Michael Berman ◽  
...  
Keyword(s):  
Laser Light ◽  
Hematoporphyrin Derivative ◽  
Systemic Injection

The Analysis of Hematoporphyrin Derivative

1983 ◽  
pp. 251-263 ◽  
Author(s):  
Peter A. Cadby ◽  
Eugene Dimitriadis ◽  
Hamish G. Grant ◽  
A. David Ward ◽  
Ian J. Forbes
Keyword(s):  
Hematoporphyrin Derivative

Cellular Uptake, Excretion and Localization of Hematoporphyrin Derivative (HPD)

1983 ◽  
pp. 139-150 ◽  
Author(s):  
Michael W. Berns ◽  
Alan Wile ◽  
Anton Dahlman ◽  
Fred Johnson ◽  
Robert Burns ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Hematoporphyrin Derivative

Tumor Fluorescence with Hematoporphyrin Derivative

1977 ◽  
Vol 86 (5) ◽  
pp. 661-666 ◽  
Author(s):  
Robert J. Carpenter ◽  
Robert J. Ryan ◽  
H. Bryan Neel ◽  
David R. Sanderson
Keyword(s):  
Normal Tissue ◽  
Bronchial Tree ◽  
Homogeneous Material ◽  
Hematoporphyrin Derivative ◽  
Light Activation ◽  
Normal Tissues ◽  
Violet Light ◽  
Tumor Periphery ◽  
Orange Fluorescence ◽  
Layer Chromatography

Hematoporphyrin derivative (HpD) is one of several photodynamically active dyes that accumulate in tumor cells and can be used to differentiate neoplastic from normal tissue by violet light activation. Degree of tumor fluorescence was studied in relation to the nature of the hematoporphyrin compound, dose of HpD injected, route of injection, and intensity of activating light. Our studies indicate that HpD is not a chromatographically homogeneous material. Four components of HpD have been identified by thin-layer chromatography; their nature is not presently known. Pure HpD is the best agent for tumor fluorescence as compared with the components studied. Intravenous injection of HpD resulted in a more intense red-orange fluorescence than that after intraperitoneal injection. Fluorescence was more intense at the tumor periphery where tumor invaded normal tissues and around blood vessels. HpD injection of 0.002 mg/gm body weight induced more selective fluorescence of tumor than did 0.01 mg/gm. Microscopic examination of tumor showed fluorescence distributed throughout the cytoplasm. A fiberoptic bronchoscope attached to the Mayo-Baldes activating light source made possible induction of slight tumor fluorescence, but the intensity of activating light would not be adequate for clinical examination of the bronchial tree and detection of tumor.

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