scholarly journals XIST Gene

2020 ◽  
Author(s):  
Keyword(s):  
Xist Gene

scholarly journals Characterization of the promoter region of the mouse Xist gene.

1995 ◽  
Vol 92 (26) ◽  
pp. 12515-12519 ◽  
Author(s):  
N. Pillet ◽  
C. Bonny ◽  
D. F. Schorderet
Keyword(s):  
Promoter Region ◽  
Xist Gene

scholarly journals Role of the Xist Gene in X Chromosome Choosing

Cell ◽  
1998 ◽  
Vol 92 (5) ◽  
pp. 657-664 ◽  
Author(s):  
York Marahrens ◽  
Jan Loring ◽  
Rudolf Jaenisch
Keyword(s):  
X Chromosome ◽  
Xist Gene

scholarly journals The detection of female cell activity in male sex chromosome chimeric Rideau Arcott sheep, using the Xist gene product as a marker

SURG Journal ◽  
2008 ◽  
Vol 1 (2) ◽  
pp. 20-25
Author(s):  
Okimi Peters ◽  
W. Allan King
Keyword(s):  
Y Chromosome ◽  
Sex Chromosome ◽  
Cell Activity ◽  
Xist Gene ◽  
Specific Gene ◽  
Xist Expression ◽  
Female Cell ◽  
Male Sex ◽  
Polymerase Chain ◽  
Xy Female

The detection of the SRY (Sex-determining region on the Y chromosome) gene is a popular method used for the identification of freemartins (XX/XY female chimeras). This method relies on the fact that the SRY gene is a Y chromosome specific gene and is thus normally only present in males therefore detecting its presence in a female indicates the presence of male cells (XY cells) within the female. This concept can be extrapolated to the male counterparts of freemartins with regards to the Xist gene. This gene is normally only widely expressed in females and can be used as a marker for identifying females. Therefore, detecting Xist gene expression in males (in tissues other than the testes, as the Xist gene is expressed exclusively in the testes of males) may indicate that these males contain transcriptionally competent female cells and thus necessarily labels them as sex-chromosome chimeras. In the present study four previously identified male sex chromosome chimeras were screened for the expression of the Xist gene using reverse transcription Polymerase Chain Reaction (PCR), and it was detected in three of the four chimeras. Xist expression was not detected in one of the chimeras because the proportion of female cells in its blood is significantly low and thus it is likely that the blood sample used in the study did not possess female cells. None-the-less it was concluded that the detection of Xist expression in male sex chromosome chimeras can be used as an indication of the presence and transcriptional competence of female cells within them.

The upstream region of the mouse Xist gene contains two ribosomal protein pseudogenes

2000 ◽  
Vol 11 (6) ◽  
pp. 461-463 ◽  
Author(s):  
Justyna T. Romer ◽  
Alan Ashworth
Keyword(s):  
Ribosomal Protein ◽  
Xist Gene ◽  
Upstream Region

scholarly journals A Regulatory Potential of the Xist Gene Promoter in Vole M. rossiaemeridionalis

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e33994 ◽  
Author(s):  
Konstantin E. Orishchenko ◽  
Sophia V. Pavlova ◽  
Eugeny A. Elisaphenko ◽  
Vladimir V. Sherstyuk ◽  
Alexander V. Prinz ◽  
...  
Keyword(s):  
Gene Promoter ◽  
Xist Gene ◽  
Regulatory Potential

scholarly journals Complex sSMC Involving X and Y Chromosomes in two Patients with 45,X/46,X,+mar Karyotype

2021 ◽  
pp. 19-23
Author(s):  
Miriam Beatriz Goulart ◽  
Monique Oliveira Freitas ◽  
Evelyn Kahn ◽  
Marilia Martins Guimarães ◽  
Isaias Soares Paiva ◽  
...  
Keyword(s):  
Cell Line ◽  
Turner Syndrome ◽  
Y Chromosome ◽  
Xist Gene ◽  
Marker Chromosomes ◽  
Y Chromosomes ◽  
Emanuel Syndrome ◽  
Small Supernumerary Marker Chromosomes ◽  
Supernumerary Marker Chromosomes

Complex small supernumerary marker chromosomes (sSMCs) consist of chromosomal material derived from two or more different chromosomal regions and constitute one of the smallest subsets of sSMC. Most of complex sSMCs are represented by a der(22)t(11;22) in Emanuel syndrome. As far as we know, only one recent report has described sSMCs involving simultaneously X and Y chromosomes in Turner Syndrome. We report two patients, a female and a male, both with a complex sSMC derived from X and Y chromosomes in mosaic with a 45,X cell line. In both patients, the marker chromosomes were early replicating and the XIST gene was absent. FISH and PCR confirmed the presence of Yp loci (TSPY, AMGY, SRY, DYZ3), and negative for DYZ1. The DAZ4 sequence was present only in patient 1.Our findings suggested that complex sSMC involving X and Y chromosome could be a kind of sSMC of the gonosomes.

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