scholarly journals Oligodendroglial tumor

2020 ◽  
Author(s):  
Keyword(s):  
Oligodendroglial Tumor

Loss of heterozygosity at 1p-19q induces a global change in oligodendroglial tumor gene expression

2009 ◽  
Vol 95 (3) ◽  
pp. 343-354 ◽  
Author(s):  
Rubén Ferrer-Luna ◽  
Manuel Mata ◽  
Lina Núñez ◽  
Jorge Calvar ◽  
Francisco Dasí ◽  
...  
Keyword(s):  
Gene Expression ◽  
Global Change ◽  
Loss Of Heterozygosity ◽  
Oligodendroglial Tumor ◽  
Tumor Gene Expression ◽  
Tumor Gene

Survival trends of oligodendroglial tumor patients and associated clinical practice patterns: a SEER-based analysis

2017 ◽  
Vol 133 (1) ◽  
pp. 173-181 ◽  
Author(s):  
Michael G. Brandel ◽  
Ali A. Alattar ◽  
Brian R. Hirshman ◽  
Xuezhi Dong ◽  
Kate T. Carroll ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Practice Patterns ◽  
Tumor Patients ◽  
Clinical Practice Patterns ◽  
Oligodendroglial Tumor

scholarly journals Anaplastic oligodendroglial tumor metastatic to the bone marrow: Molecular heterogeneity of glial neoplasms and the clinical importance of minor clones

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Carrie A. Mohila ◽  
Nathan E. Simmons ◽  
Camilo E. Fadul ◽  
Louise P. Meyer ◽  
Alan C. Hartford ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Clinical Importance ◽  
Molecular Heterogeneity ◽  
Oligodendroglial Tumor

Radiomics method to predict loss of heterozygosity on chromosome 1p/19q of oligodendroglial tumor.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 2043-2043
Author(s):  
Jingwei Wei ◽  
Jie Tian
Keyword(s):  
Loss Of Heterozygosity ◽  
Tumor Resection ◽  
Feature Model ◽  
Molecular Signature ◽  
Support Vector ◽  
P Value ◽  
Imaging Features ◽  
Clinical Predictors ◽  
Oligodendroglial Tumor ◽  
Chromosome 1P

2043 Background: Oligodendroglial tumor (OT) is one of the main types of gliomas, which is incurable in current situation. As a tumor-specific genetic alteration of OTs, loss of heterozygosity (LOH) on chromosome 1p/19q indicates a preferable response to chemo/radiotherapy and a better survial, which could be used as a key molecular signature for personalized treatment decision making. However, 1p/19q LOH status is now commonly obtained by fluorescence in situ hybridization after the tumor resection, which is highly likely to lead functin deficit with tumor locating on eloquent area. Thus, a noninvasive predicition on 1p/19q LOH is required. Here, we used a "Radiomics" method to achieve the prediction based on magnetic resonance imaging in this study. Methods: A cohort of 113 OT patients was collected from Beijing Tiantan Hospital. 593 three-dimensional imaging features were extracted on T2-weighted images including textural and non-textural features. We used "minimum redundancy maximum relevance" and "iterative backward elemination and forward inclusion" algorithms to pick up the most effective features with a p-value < 0.05. With the selected features as the input, support vector machine algorithm was adopted to predict the 1p/19q LOH status with 10-fold cross validation. Comparisons were made between the traditional clinical predictors and the established model. Results: The prediction accuracy for 1p/19q LOH turned out to be 86.6%. The top three features contributing most to the prediction were respectively: GlobalUniformity, GaborBankD4GLRLMLGRE and GaborBankD4GLRLMSRLGE. The predictive performance of the radiomics model was proved to be far more valid than the clinical predictors (indistict tumor border and heterogeneous signal intensity) with the higher area under curve (AUC). Compared with the best single feature (GlobalUniformity, AUC: 0.749), this combined-feature model has the best diagnostic performance with an AUC of 0.898. Conclusions: This study reveals the intrinsic association between the imaging features and 1p/19q LOH status, meanwhile, realizes the high precision prediction, providing reliable basis for the pre-operative treatment regime.

scholarly journals NT-22 * PAV TREATMENT WITHOUT IMMEDIATE RADIOTHERAPY FOR ANAPLASTIC OLIGODENDROGLIAL TUMOR WITH 1p/19q CO-DELETION

2014 ◽  
Vol 16 (suppl 5) ◽  
pp. v163-v163
Author(s):  
T. Matsutani ◽  
S. Hirono ◽  
N. Shinozaki ◽  
Y. Iwadate ◽  
N. Saeki
Keyword(s):  
Oligodendroglial Tumor

Oligodendroglial tumor chemotherapy using "decreased-dose-intensity" PCV: A Singapore experience

Neurology ◽  
2006 ◽  
Vol 66 (2) ◽  
pp. 247-249 ◽  
Author(s):  
A. U. Ty ◽  
S. J. See ◽  
J. P. Rao ◽  
J.B.K. Khoo ◽  
M. C. Wong
Keyword(s):  
Dose Intensity ◽  
Oligodendroglial Tumor

scholarly journals Multimodal MR Imaging (Diffusion, Perfusion, and Spectroscopy): Is It Possible to Distinguish Oligodendroglial Tumor Grade and 1p/19q Codeletion in the Pretherapeutic Diagnosis?

2012 ◽  
Vol 34 (7) ◽  
pp. 1326-1333 ◽  
Author(s):  
S. Fellah ◽  
D. Caudal ◽  
A.M. De Paula ◽  
P. Dory-Lautrec ◽  
D. Figarella-Branger ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Tumor Grade ◽  
Oligodendroglial Tumor
Sign in / Sign up

Export Citation Format

Share Document