scholarly journals Gamma-Aminobutyric Acid Type B Receptor Subunit 2

2020 ◽  
Author(s):  
Keyword(s):  
Aminobutyric Acid ◽  
Receptor Subunit ◽  
Gamma Aminobutyric Acid ◽  
Type B ◽  
Acid Type

scholarly journals Altered Gamma-Aminobutyric Acid Type B Receptor Subunit 1 Splicing In Alcoholics

2014 ◽  
Vol 75 (10) ◽  
pp. 765-773 ◽  
Author(s):  
Changhoon Lee ◽  
R. Dayne Mayfield ◽  
R. Adron Harris
Keyword(s):  
Aminobutyric Acid ◽  
Receptor Subunit ◽  
Gamma Aminobutyric Acid ◽  
Type B ◽  
Acid Type

scholarly journals Modifications in Gamma-aminobutyric Acid type A Receptor Subunit Gene Expression During Macrophage Differentiation and Propofol Administration in THP-1 Cells

2021 ◽  
Author(s):  
Tsukasa Kochiyama ◽  
Izumi Kawagoe ◽  
Ai Yamaguchi ◽  
Masataka Fukuda ◽  
Masakazu Hayashida
Keyword(s):  
Gene Expression ◽  
Immune Cells ◽  
Type A ◽  
Aminobutyric Acid ◽  
Receptor Subunit ◽  
Gamma Aminobutyric Acid ◽  
Subunit Gene ◽  
Macrophage Differentiation ◽  
Anesthetic Agents ◽  
Acid Type

Abstract Background: Gamma-aminobutyric acid type A (GABAA) receptors are thought to play a role in the functioning of the immune system. GABAA receptors have 19 types of subunits, the components of which determine their physiological functions. However, the subunits that are expressed in immune cells during inflammation have not been fully investigated. Recent reports have shown that anesthetic agents may affect the gene expression of GABAA receptors subunits in immune cells. Therefore, we aimed to investigate the changes in GABAA receptor subunit gene expression during macrophage differentiation and propofol administration in order to clarify the relationship between the expression of GABAA receptors and the immunomodulatory effect of propofol.Methods: Human acute monocytic leukemia (THP-1) cells were differentiated into macrophage-like cells (M0 THP-1); subsequently, M0 THP-1 cells were differentiated into inflammatory M1 macrophage-like cells (M1 THP-1). Propofol was administered during the differentiation into M1 THP-1 cells. Using reverse transcriptase polymerase chain reaction, we examined which GABAA receptor subunit genes were expressed and whether there were changes in the gene expression during macrophage differentiation and propofol administration in THP-1 cells.Results: The expression of the α1, α4, β1, β2, γ1, and γ2 subunits increased during differentiation into M0 THP-1 cells. The expression of the α1, α4, β1, β2, γ2, and δ subunits decreased and that of the γ1 subunit increased during differentiation into M1 THP-1 cells. The gene expression of the α1, α4, and β2 subunits increased upon administering propofol during differentiation into M1 THP-1 cells.Conclusions: The gene expression of GABAA receptor subunits changed during macrophage differentiation in THP-1 cells. The expressions of α1 and α4 increased following propofol administration during the differentiation into M1 THP-1 cells, which may indicate that the GABAA receptor is involved in the immunosuppressive effects of propofol. This study can help in the choice of anesthetic agents for proinflammatory conditions such as highly-invasive surgery.

scholarly journals theta , a novel gamma -aminobutyric acid type A receptor subunit

1999 ◽  
Vol 96 (17) ◽  
pp. 9891-9896 ◽  
Author(s):  
T. P. Bonnert ◽  
R. M. McKernan ◽  
S. Farrar ◽  
B. le Bourdelles ◽  
R. P. Heavens ◽  
...  
Keyword(s):  
Type A ◽  
Aminobutyric Acid ◽  
Receptor Subunit ◽  
Gamma Aminobutyric Acid ◽  
Acid Type

scholarly journals gamma -Aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes

2000 ◽  
Vol 97 (15) ◽  
pp. 8664-8669 ◽  
Author(s):  
P. Lorente ◽  
A. Lacampagne ◽  
Y. Pouzeratte ◽  
S. Richards ◽  
B. Malitschek ◽  
...  
Keyword(s):  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Type B ◽  
Acid Type
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