Interleukin-11

2020 ◽  
Author(s):  
Keyword(s):  
Interleukin 11

Reduced bone formation and increased adiposity with insulin resistance in interleukin-11 deficient mice

2014 ◽  
Author(s):  
Bingzi Dong ◽  
Takeshi Kondo ◽  
Yukiyo Ohnishi ◽  
Itsuro Endo ◽  
Masahiro Abe ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Bone Formation ◽  
Interleukin 11 ◽  
Deficient Mice

M1959 Helicobacter pylori cagA Tyrosine Phosphorylation Triggers the Interleukin-11/STAT3 Pathway in Gastric Epithelial Cells

2010 ◽  
Vol 138 (5) ◽  
pp. S-448
Author(s):  
Kai Syin Lee ◽  
Anastasia Kalantzis ◽  
Naoko Murata-Kamiya ◽  
Masanori Hatakeyama ◽  
Andrew S. Giraud ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Tyrosine Phosphorylation ◽  
Gastric Epithelial Cells ◽  
Stat3 Pathway ◽  
Interleukin 11

scholarly journals Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Takashi Nishina ◽  
Yutaka Deguchi ◽  
Daisuke Ohshima ◽  
Wakami Takeda ◽  
Masato Ohtsuka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Cells ◽  
Human Cancer ◽  
Tumor Development ◽  
Gene Signature ◽  
Free Survival ◽  
Expression Of Genes ◽  
Reporter Mice ◽  
Interleukin 11

AbstractInterleukin (IL)-11 is a member of the IL-6 family of cytokines and is involved in multiple cellular responses, including tumor development. However, the origin and functions of IL-11-producing (IL-11+) cells are not fully understood. To characterize IL-11+ cells in vivo, we generate Il11 reporter mice. IL-11+ cells appear in the colon in murine tumor and acute colitis models. Il11ra1 or Il11 deletion attenuates the development of colitis-associated colorectal cancer. IL-11+ cells express fibroblast markers and genes associated with cell proliferation and tissue repair. IL-11 induces the activation of colonic fibroblasts and epithelial cells through phosphorylation of STAT3. Human cancer database analysis reveals that the expression of genes enriched in IL-11+ fibroblasts is elevated in human colorectal cancer and correlated with reduced recurrence-free survival. IL-11+ fibroblasts activate both tumor cells and fibroblasts via secretion of IL-11, thereby constituting a feed-forward loop between tumor cells and fibroblasts in the tumor microenvironment.

Interleukin-11: Review of Molecular, Cell Biology, and Clinical Use

Blood ◽  
1997 ◽  
Vol 89 (11) ◽  
pp. 3897-3908 ◽  
Author(s):  
Xunxiang Du ◽  
David A. Williams
Keyword(s):  
Cell Biology ◽  
Clinical Use ◽  
Molecular Cell Biology ◽  
Interleukin 11

scholarly journals Mediation of interleukin-11-dependent biological responses by a soluble form of the interleukin-11 receptor

1996 ◽  
Vol 318 (2) ◽  
pp. 489-495 ◽  
Author(s):  
Julia KAROW ◽  
Keith R. HUDSON ◽  
Mark A. HALL ◽  
Ann B. VERNALLIS ◽  
Jacky A. TAYLOR ◽  
...  
Keyword(s):  
Biological Effects ◽  
Biological Response ◽  
Cytoplasmic Domain ◽  
Soluble Form ◽  
High Affinity ◽  
Biological Responses ◽  
Interleukin 11 ◽  
Biological Actions ◽  
In Cells

Interleukin-11 (IL-11) is a polyfunctional cytokine whose biological actions require a specific IL-11 receptor (IL-11R) and the transmembrane transducer gp130. Here we report the production of a soluble form of the murine IL-11R and demonstrate that it interacts with IL-11 ligand with high affinity. The affinity of IL-11 alone for gp130 is below the level of detection, but a complex of IL-11 and soluble IL-11R interacts with gp130 with high affinity. The addition of soluble IL-11R potentiates the effects of exogenous IL-11 in cells that are normally responsive to IL-11. A biological response to IL-11 can be reconstituted in BAF cells transfected with gp130 by addition of IL-11 and soluble IL-11R. These findings show that the cytoplasmic domain of the IL-11R is not required for the biological effects of IL-11 and that a complex of IL-11 and IL-11R mediates signalling by association with gp130.

Recombinant human interleukin-11 (IL-11) is a protective factor in severe sepsis with thrombocytopenia: A case-control study

Cytokine ◽  
2015 ◽  
Vol 76 (2) ◽  
pp. 138-143 ◽  
Author(s):  
Bing Wan ◽  
Hao Zhang ◽  
Haiyan Fu ◽  
Yikun Chen ◽  
Liping Yang ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Protective Factor ◽  
Case Control Study ◽  
Case Control ◽  
Interleukin 11 ◽  
Control Study

scholarly journals The Production of Interleukin-11 and Decidualization Are Compromised in Endometrial Stromal Cells Derived from Patients with Infertility

2005 ◽  
Vol 90 (3) ◽  
pp. 1607-1612 ◽  
Author(s):  
Natalia Karpovich ◽  
Petra Klemmt ◽  
Jung Hye Hwang ◽  
J. Enda McVeigh ◽  
John K. Heath ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Endometrial Stromal Cells ◽  
Interleukin 11
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