Basophilic Cell

2020 ◽  
Author(s):  
Keyword(s):  
Basophilic Cell

scholarly journals Synergistic effects of nerve growth factor and granulocyte-macrophage colony-stimulating factor on human basophilic cell differentiation

Blood ◽  
1991 ◽  
Vol 77 (5) ◽  
pp. 971-979 ◽  
Author(s):  
T Tsuda ◽  
D Wong ◽  
J Dolovich ◽  
J Bienenstock ◽  
J Marshall ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Colony Stimulating Factor ◽  
Nerve Growth ◽  
Basophilic Cell ◽  
Gm Csf ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Abstract We have recently shown that nerve growth factor (NGF) promotes human granulopoiesis, specifically augmenting basophilic cell differentiation observed in methylcellulose hematopoietic colony assays of human peripheral blood. Because the NGF effect was seen in the presence of conditioned medium derived from a human T-cell line (Mo-CM) containing granulocyte-macrophage colony-stimulating factor (GM-CSF), we examined interactions of purified NGF and recombinant human GM-CSF (rhGM-CSF) on granulocyte growth and differentiation. rhGM-CSF stimulated a dose- dependent increase in methylcellulose colony growth at concentrations between 0.1 U/mL and 10 U/mL, and in the presence of NGF at 500 ng/mL this effect was enhanced. The number of basophilic cell colony-forming units (CFU-Baso) and histamine-positive colonies increased synergistically when NGF was added to rhGM-CSF. Furthermore, because Mo- CM acts with sodium butyrate to promote basophilic differentiation of alkaline-passaged myeloid leukemia cells, HL-60, we also examined the interaction of NGF and Mo-CM or rhGM-CSF using this assay. In the presence of NGF, Mo-CM at concentrations of 0.5% to 20% vol/vol, and rhGM-CSF at concentrations of 0.1 U/mL to 100 U/mL synergistically increased histamine production by butyrate-induced, alkaline-passaged HL-60 cells; this was associated with the appearance of metachromatic, tryptase-negative, IgE receptor-positive cells. The effects of rhGM-CSF or Mo-CM were completely abrogated by a specific anti-rhGM-CSF neutralizing antibody in methylcellulose, with or without NGF; the NGF synergy with rhGM-CSF in the HL-60 assay was also inhibited by either anti-rhGM-CSF or anti-NGF antibody. These studies support the notion that differentiation in the basophilic lineage may be enhanced by NGF acting to increase the number of GM-CSF-responsive basophilic cell progenitors.

Human Basophilic Cell Differentiation Promoted by 2.5S Nerve Growth Factor

1988 ◽  
Vol 86 (4) ◽  
pp. 453-457 ◽  
Author(s):  
Hiroshi Matsuda ◽  
Jan Switzer ◽  
Michael D. Coughlin ◽  
John Bienenstock ◽  
Judah A. Denburg
Keyword(s):  
Cell Differentiation ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Basophilic Cell

scholarly journals Induction of human IgE synthesis in B cells by a basophilic cell line, KU812

1997 ◽  
Vol 108 (2) ◽  
pp. 295-301 ◽  
Author(s):  
Y. YANAGIHARA ◽  
K. KAJIWARA ◽  
Y. BASAKI ◽  
K. IKIZAWA ◽  
K. AKIYAMA ◽  
...  
Keyword(s):  
B Cells ◽  
Cell Line ◽  
Basophilic Cell ◽  
Ige Synthesis

Constitutive and Inducible Expression of PDGF in the Human Basophilic Cell Line, KU 812

1993 ◽  
Vol 9 (3) ◽  
pp. 231-241 ◽  
Author(s):  
K. Forsberg ◽  
G. Nilsson ◽  
Z. P. Ren ◽  
L. Hellman ◽  
B. Westermark ◽  
...  
Keyword(s):  
Cell Line ◽  
Inducible Expression ◽  
Basophilic Cell

IgE in the absence of allergen induces the expression of monocyte chemoattractant protein-1 in the rat basophilic cell-line RBL-2H3

2014 ◽  
Vol 62 (1) ◽  
pp. 114-121 ◽  
Author(s):  
Ki Bum Ahn ◽  
Jun Ho Jeon ◽  
Seok-Seong Kang ◽  
Dae Kyun Chung ◽  
Cheol-Heui Yun ◽  
...  
Keyword(s):  
Cell Line ◽  
Monocyte Chemoattractant Protein 1 ◽  
Basophilic Cell ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

scholarly journals Molecular Cloning and Functional Expression of a Novel CC Chemokine Receptor cDNA from a Human Basophilic Cell Line

1995 ◽  
Vol 270 (33) ◽  
pp. 19495-19500 ◽  
Author(s):  
Christine A. Power ◽  
Alexandra Meyer ◽  
Karin Nemeth ◽  
Kevin B. Bacon ◽  
Arlene J. Hoogewerf ◽  
...  
Keyword(s):  
Cell Line ◽  
Molecular Cloning ◽  
Chemokine Receptor ◽  
Functional Expression ◽  
Basophilic Cell ◽  
Cc Chemokine ◽  
Receptor Cdna
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