scholarly journals Orbital Muscle Entrapment

2020 ◽  
Author(s):  
Keyword(s):  
Orbital Muscle

scholarly journals Cutting Edge: Retrobulbar Inflammation, Adipogenesis, and Acute Orbital Congestion in a Preclinical Female Mouse Model of Graves' Orbitopathy Induced by Thyrotropin Receptor Plasmid-in Vivo Electroporation

Endocrinology ◽  
2013 ◽  
Vol 154 (9) ◽  
pp. 3008-3015 ◽  
Author(s):  
Sajad Moshkelgosha ◽  
Po-Wah So ◽  
Neil Deasy ◽  
Salvador Diaz-Cano ◽  
J Paul Banga
Keyword(s):  
Therapeutic Interventions ◽  
Preclinical Model ◽  
Orbital Tissue ◽  
Mri Scans ◽  
A Subunit ◽  
Graves Orbitopathy ◽  
Orbital Muscle ◽  
Magnetic Resonance Imaging Mri ◽  
Blocking Antibodies

Graves' orbitopathy (GO) is a complication in Graves' disease (GD) but mechanistic insights into pathogenesis remain unresolved, hampered by lack of animal model. The TSH receptor (TSHR) and perhaps IGF-1 receptor (IGF-1R) are considered relevant antigens. We show that genetic immunization of human TSHR (hTSHR) A-subunit plasmid leads to extensive remodeling of orbital tissue, recapitulating GO. Female BALB/c mice immunized with hTSHR A-subunit or control plasmids by in vivo muscle electroporation were evaluated for orbital remodeling by histopathology and magnetic resonance imaging (MRI). Antibodies to TSHR and IGF-1R were present in animals challenged with hTSHR A-subunit plasmid, with predominantly TSH blocking antibodies and were profoundly hypothyroid. Orbital pathology was characterized by interstitial inflammation of extraocular muscles with CD3+ T cells, F4/80+ macrophages, and mast cells, accompanied by glycosaminoglycan deposition with resultant separation of individual muscle fibers. Some animals showed heterogeneity in orbital pathology with 1) large infiltrate surrounding the optic nerve or 2) extensive adipogenesis with expansion of retrobulbar adipose tissue. A striking finding that underpins the new model were the in vivo MRI scans of mouse orbital region that provided clear and quantifiable evidence of orbital muscle hypertrophy with protrusion (proptosis) of the eye. Additionally, eyelid manifestations of chemosis, including dilated and congested orbital blood vessels, were visually apparent. Immunization with control plasmids failed to show any orbital pathology. Overall, these findings support TSHR as the pathogenic antigen in GO. Development of a new preclinical model will facilitate molecular investigations on GO and evaluation of new therapeutic interventions.

Hemodynamic implications of the orbital muscle of Müller An anatomical study of human fetal, neonatal, and adult specimens

1999 ◽  
Vol 22 (4) ◽  
pp. 201-207 ◽  
Author(s):  
E. Van Wirdum ◽  
R.J.W. De Keizer ◽  
C.A.C. Entius ◽  
Chr. Vermeij-Keers
Keyword(s):  
Anatomical Study ◽  
Orbital Muscle ◽  
Orbital Muscle Of Müller

Some aspects of Muller’s orbital muscle

1950 ◽  
Vol 25 (1) ◽  
pp. 39-42 ◽  
Author(s):  
Liam G. O’Connell
Keyword(s):  
Orbital Muscle

scholarly journals The Spatial Aspect and Fine Structure of the Orbital Muscle of the Mouse

1980 ◽  
Vol 56 (6) ◽  
pp. 383-387 ◽  
Author(s):  
TOSHIO YAMASHITA ◽  
AKIRA TAKAHASHI ◽  
RYOHEI HONJIN
Keyword(s):  
Fine Structure ◽  
Spatial Aspect ◽  
Orbital Muscle

Anatomic relationships of the orbital muscle of Müller in human fetuses

1999 ◽  
Vol 20 (5) ◽  
pp. 341-344
Author(s):  
J. F. Rodríguez-Vázquez ◽  
J. R. Mérida-Velasco ◽  
L. A. Arráez-Aybar ◽  
J. Jiménez-Collado
Keyword(s):  
Human Fetuses ◽  
Orbital Muscle ◽  
Orbital Muscle Of Müller

scholarly journals Innervation of the Orbital Muscle of the Mouse

1982 ◽  
Vol 58 (4-6) ◽  
pp. 543-553 ◽  
Author(s):  
TOSHIO YAMASHITA ◽  
AKIRA TAKAHASHI ◽  
HIROMASA TANAKA ◽  
RYOHEI HONJIN
Keyword(s):  
Orbital Muscle

Delayed Hypersensitivity in Graves' Disease and Exophthalmos: Identification of Thyroglobulin in Normal Human Orbital Muscle

Endocrinology ◽  
1977 ◽  
Vol 100 (2) ◽  
pp. 351-366 ◽  
Author(s):  
BRIAN R. MULLIN ◽  
RACHEL E. LEVINSON ◽  
ADOLPH FRIEDMAN ◽  
DONALD E. HENSON ◽  
ROGER J. WINAND ◽  
...  
Keyword(s):  
Delayed Hypersensitivity ◽  
Graves Disease ◽  
Normal Human ◽  
Orbital Muscle
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