scholarly journals Dioscorea nipponica Makino Extract DNE3

2020 ◽  
Author(s):  
Keyword(s):  
Dioscorea Nipponica Makino

Effects of the Total Saponins fromDioscorea nipponicaon Immunoregulation in Aplastic Anemia Mice

2015 ◽  
Vol 43 (02) ◽  
pp. 289-303 ◽  
Author(s):  
Yuliang Wang ◽  
Tiangai Yan ◽  
Lin Ma ◽  
Baoshan Liu
Keyword(s):  
Bone Marrow ◽  
Aplastic Anemia ◽  
Inflammatory Cytokine ◽  
Folk Medicine ◽  
Apoptosis Protein ◽  
Dioscorea Nipponica Makino ◽  
Regulation Mechanisms ◽  
Th1 Cytokines ◽  
Different Doses ◽  
Medium Dose

Dioscorea nipponica Makino, a popular folk medicine, exerts anti-inflammation properties. The present study investigated the therapeutic effect of the total saponins from Dioscorea nipponica Makino (TSDN) on aplastic anemia (AA) and possible immune regulation mechanisms. Using a mouse model of AA, three different doses of TSDN were orally administrated for 14 consecutive days. We first demonstrated that TSDN was found to be effective in alleviating pancytopenia with a hypocellular bone marrow as compared with AA model group. Moreover, gastrogavage administration of a medium dose of TSDN was found to dramatically increase the percentage of CD4+cells in bone marrow nucleated cells (BMNC) and restore the CD4+/CD8+ratio. The pro-inflammatory cytokine concentrations of IL-2 and IFN-γ were significantly decreased, and anti-inflammatory cytokine IL-4 was significantly increased in culture supernatant of BMNC. Further investigations showed that TSDN obviously inhibited Fas–FasL-induced BMNC apoptosis as well as effectively suppressed intracellular apoptosis protein of caspase-3 and -8 expressions. Taken together, these findings suggested that TSDN could alleviate AA by elevating the CD4+/CD8+T-cell ratio, inhibiting inflammatory Th1-cytokines, and exerting anti-apoptosis effects.

Novel phenanthrene and isocoumarin from the rhizomes of Dioscorea nipponica Makino subsp. rosthornii (Prain et Burkill) C. T. Ting (Dioscoreaceae)

2017 ◽  
Vol 27 (15) ◽  
pp. 3595-3601 ◽  
Author(s):  
Xuejiao Li ◽  
Chengcheng Zhao ◽  
Songsong Jing ◽  
Jiachen Sun ◽  
Xia Li ◽  
...  
Keyword(s):  
Dioscorea Nipponica Makino
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