scholarly journals Colon Serrated Adenocarcinoma

2020 ◽  
Author(s):  
Keyword(s):  
Serrated Adenocarcinoma

scholarly journals Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma

2011 ◽  
Vol 58 (5) ◽  
pp. 679-692 ◽  
Author(s):  
Karoliina Stefanius ◽  
Laura Ylitalo ◽  
Anne Tuomisto ◽  
Rami Kuivila ◽  
Tiina Kantola ◽  
...  
Keyword(s):  
Serrated Adenocarcinoma ◽  
Frequent Mutations

scholarly journals Clinicopathological Features of Serrated Adenocarcinoma Defined by Mäkinen in Dukes’ B Colorectal Carcinoma

Pathobiology ◽  
2012 ◽  
Vol 79 (4) ◽  
pp. 169-174 ◽  
Author(s):  
Yosuke Shida ◽  
Takahiro Fujimori ◽  
Hiroyuki Tanaka ◽  
Yukari Fujimori ◽  
Ryusuke Kimura ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Clinicopathological Features ◽  
Serrated Adenocarcinoma

scholarly journals Biology and Therapeutic Targets of Colorectal Serrated Adenocarcinoma; Clues for a Histologically Based Treatment against an Aggressive Tumor

2020 ◽  
Vol 21 (6) ◽  
pp. 1991
Author(s):  
Begoña Alburquerque-González ◽  
Fernando F. López-Calderón ◽  
María Dolores López-Abellán ◽  
Ángel Esteban-Gil ◽  
José García-Solano ◽  
...  
Keyword(s):  
Immune Response ◽  
Targeted Therapy ◽  
Molecular Targets ◽  
Current Evidence ◽  
Colorectal Carcinomas ◽  
Histological Subtype ◽  
Invasive Front ◽  
Serrated Adenocarcinoma ◽  
Aggressive Tumor ◽  
Worse Prognosis

Serrated adenocarcinoma (SAC) is a tumor recognized by the WHO as a histological subtype accounting for around 9% of colorectal carcinomas. Compared to conventional carcinomas, SACs are characterized by a worse prognosis, weak development of the immune response, an active invasive front and a frequent resistance to targeted therapy due to a high occurrence of KRAS or BRAF mutation. Nonetheless, several high-throughput studies have recently been carried out unveiling the biology of this cancer and identifying potential molecular targets, favoring a future histologically based treatment. This review revises the current evidence, aiming to propose potential molecular targets and specific treatments for this aggressive tumor.

Immunohistochemical expression profile of β-catenin, E-cadherin, P-cadherin, laminin-5γ2 chain, and SMAD4 in colorectal serrated adenocarcinoma

2012 ◽  
Vol 43 (7) ◽  
pp. 1094-1102 ◽  
Author(s):  
José García-Solano ◽  
Pablo Conesa-Zamora ◽  
Javier Trujillo-Santos ◽  
Daniel Torres-Moreno ◽  
Markus J. Mäkinen ◽  
...  
Keyword(s):  
Expression Profile ◽  
Immunohistochemical Expression ◽  
Serrated Adenocarcinoma ◽  
E Cadherin

The essential role of BRAF and KRAS mutations in colorectal serrated adenocarcinoma

2008 ◽  
Vol 6 (9) ◽  
pp. 39-40
Author(s):  
L. Pukkila ◽  
K. Tuppurainen ◽  
T.J. Karttunen ◽  
M.J. Mäkinen
Keyword(s):  
Essential Role ◽  
Kras Mutations ◽  
Serrated Adenocarcinoma

scholarly journals Serrated adenocarcinoma morphology in colorectal mucinous adenocarcinoma is associated with improved patient survival

Oncotarget ◽  
2017 ◽  
Vol 8 (21) ◽  
pp. 35165-35175 ◽  
Author(s):  
Chung-Ta Lee ◽  
Yu-Chuan Huang ◽  
Liang-Yi Hung ◽  
Nan-Haw Chow ◽  
Pei-Fang Su ◽  
...  
Keyword(s):  
Mucinous Adenocarcinoma ◽  
Patient Survival ◽  
Serrated Adenocarcinoma ◽  
Colorectal Mucinous Adenocarcinoma
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