scholarly journals Adenosine Nucleotide Transporter

2020 ◽  
Author(s):  
Keyword(s):  
Adenosine Nucleotide

Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors

1986 ◽  
Vol 6 (11) ◽  
pp. 4104-4108
Author(s):  
S Dandekar ◽  
S Sukumar ◽  
H Zarbl ◽  
L J Young ◽  
R D Cardiff
Keyword(s):  
Mammary Tumors ◽  
3T3 Cells ◽  
Mouse Mammary Tumor ◽  
Mouse Mammary Tumors ◽  
Transforming Activity ◽  
Radiation Induced ◽  
Genomic Dnas ◽  
Nih 3T3 ◽  
Adenosine Nucleotide ◽  
Nih 3T3 Cells

Genomic DNAs from dimethylbenzanthracene-induced BALB/c mouse mammary tumors arising from the transplantable hyperplastic outgrowth (HPO) line designated DI/UCD transformed NIH 3T3 cells upon transfection. Transforming activity was attributed to the presence of activated Harvey ras-1 oncogenes containing an A----T transversion at the middle adenosine nucleotide in codon 61. DNAs from untreated DI/UCD HPO cells and radiation-induced and spontaneous mammary tumors from the DI/UCD HPO line failed to transform NIH 3T3 cells. The results indicated that the mutation activation of Harvey ras-1 oncogenes was specific to dimethylbenzanthracene treatment in the mouse mammary tumor system.

Signaling Mismatch Repair: The Mechanics of an Adenosine-Nucleotide Molecular Switch

2000 ◽  
Vol 65 (0) ◽  
pp. 217-224 ◽  
Author(s):  
R. FISHEL ◽  
S. ACHARYA ◽  
M. BERARDINI ◽  
T. BOCKER ◽  
N. CHARBONNEAU ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Molecular Switch ◽  
Adenosine Nucleotide

Formation of adenosine nucleotide derivatives in isolated hog carotid artery strips

1977 ◽  
Vol 233 (2) ◽  
pp. H299-H304
Author(s):  
G. L. Van Harn ◽  
R. Rubio ◽  
R. M. Berne
Keyword(s):  
Carotid Artery ◽  
Specific Activity ◽  
Purine Derivatives ◽  
Twofold Increase ◽  
Threefold Increase ◽  
Isolated Artery ◽  
Adenosine Nucleotide

Media strips of hog carotid artery formed hypoxanthine and inosine during incubation under conditions of normoxia (95% O2, 5% CO2). During anoxia (95% N2, 5% CO2), hypoxanthine increased fivefold and inosine twofold. Stimulation with 124 mM K+ resulted in a twofold increase in hypoxanthine and a threefold increase in inosine. Concurrent with the increase in the concentrations of purine derivatives was a decrease in tissue ATP. Although significant amounts of adenosine were not detected in the medium of incubating artery strips, the following evidence suggests adenosine was formed and rapidly deaminated to inosine: 1) Exogenous adenosine added to the medium of incubating strips was rapidly deaminated to inosine. 2) Exogenous 5'-AMP concentration decreased, whereas adenosine and, subsequently, inosine levels increased during incubation of artery strips. The reaction was specific for 5'-AMP and the data suggest that AMP is dephosphorylated to adenosine. 3) The specific activity of exogenous [U-14C]adenosine added to the medium of incubated strips decreased after 15 min. It is concluded that adenosine is formed in isolated artery strips but is rapidly deaminated to inosine.

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