scholarly journals Calcium Deficiency Rickets

2020 ◽  
Author(s):  
Keyword(s):  
Calcium Deficiency ◽  
Deficiency Rickets

CALCIUM DEFICIENCY RICKETS AND THE RENAL RESPONSE TO CALCIUM INFUSION

PEDIATRICS ◽  
1970 ◽  
Vol 46 (6) ◽  
pp. 865-870
Author(s):  
Howard E. Maltz ◽  
Mathews B. Fish ◽  
Malcolm A. Holliday
Keyword(s):  
Fanconi Syndrome ◽  
Calcium Deficiency ◽  
Renal Lesions ◽  
High Calcium ◽  
High Calcium Diet ◽  
Calcium Infusion ◽  
Urinary Amino Acids ◽  
Deficiency Rickets ◽  
Urinary Amino ◽  
Intravenous Calcium

The diagnosis in a 1-year-old female with skeletal and chemical rickets, generalized hyperaminoaciduria, and metabolic acidosis was uncertain, and primary renal disease (i.e., Fanconi "syndrome") was considered. She had been on a diet which was deficient in calcium (approximately 21 to 36 mg calcium daily) but adequate for phosphorus and vitamin D. Her skeletal and renal lesions resolved within 3 months on a high calcium diet. Early in her hospital course, an intravenous calcium infusion provided 10 mg/kg calcium, as calcium gluconate over 3 hours; 8 to 10 hours later, a significant reduction in urinary amino acids and phosphorus was observed. The mechanism through which this response was mediated is postulated to be via reduction in circulating parathormone.

Calcium-deficiency rickets in a four-year-old boywith milk allergy

1993 ◽  
Vol 122 (2) ◽  
pp. 249-251 ◽  
Author(s):  
M. Davidovits ◽  
Y. Levy ◽  
T. Avramovitz ◽  
B. Eisenstein
Keyword(s):  
Calcium Deficiency ◽  
Milk Allergy ◽  
Deficiency Rickets

Severe Renal Osteodystrophy Without Elevated Serum Immunoreactive Parathyroid Hormone Concentrations in Hypomagnesemia Due to Renal Magnesium Wasting

PEDIATRICS ◽  
1987 ◽  
Vol 79 (3) ◽  
pp. 403-409
Author(s):  
Israel Zelikovic ◽  
Shermine Dabbagh ◽  
Aaron L. Friedman ◽  
Mark L. Goelzer ◽  
Russell W. Chesney
Keyword(s):  
Renal Failure ◽  
Parathyroid Hormone ◽  
Elevated Serum ◽  
Fractional Excretion ◽  
Calcium Deficiency ◽  
Deficiency Rickets ◽  
Renal Magnesium Wasting ◽  
Magnesium Excretion ◽  
Moderate Renal Failure ◽  
Immunoreactive Parathyroid Hormone

An 8½-year-old girl presented with a long history of seizures, growth retardation, muscle weakness, gait disturbance, and hearing loss. Her evaluation revealed chronic moderate renal failure (serum creatinine 2.2 mg/dL), severe hypocalcemia (5 mg/dL), hyperphosphatemia (8.1 mg/dL), hypomagnesemia (1.5 mg/dL), increased urinary magnesium excretion (2 mg/kg/d), high fractional excretion of magnesium (21.7%), hypokalemia (3.2 mEq/L), and hyperkaliuria (26 mEq/L). Low circulating immunoreactive parathyroid hormone levels for the degree of the hypocalcemia (serum N-parathyroid hormone 212 pg/mL) and severe rickets without evidence of osteitis fibrosa cystica were found. The patient probably has primary renal leak hypomagnesemia (magnesuric hypomagnesemia) which caused impaired secretion of immunoreactive parathyroid hormone leading to severe hypocalcemia and calcium deficiency rickets. Treatment with magnesium and calcium supplements, calcitriol, and aluminum hydroxide resulted in marked clinical, biochemical, and radiologic improvement. Calcium deficiency rickets due to primary or secondary renal magnesium wasting in conjunction with moderate renal failure represents a largely unrecognized metabolic bone disease.

Calcium Deficiency Rickets?: Fanconi Syndrome?

PEDIATRICS ◽  
1971 ◽  
Vol 47 (5) ◽  
pp. 958-959
Author(s):  
Gerard Fareau ◽  
Malcolm A. Holliday
Keyword(s):  
Fanconi Syndrome ◽  
Clinical Laboratory ◽  
Calcium Deficiency ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
X Ray ◽  
Cow's Milk ◽  
Severe Diarrhea ◽  
Milk Substitute ◽  
Deficiency Rickets

With regard to the article1 by Drs. Maltz, Fish, and Holliday in the December, 1970, issue, it seems to me that a child who keeps having severe diarrhea on regular feedings and improves on a milk substitute diet is probably suffering from cow's milk allergy. The fact that the patient tolerated cow's milk at 13 months of age does not rule this out. I would also like to point out that all the clinical, laboratory, and x-ray findings described by the authors are those of Vitamin D deficiency rickets.

Vitamin D treatment in calcium-deficiency rickets

Bone ◽  
2009 ◽  
Vol 45 ◽  
pp. S56-S57
Author(s):  
T.D. Thacher ◽  
P.R. Fischer ◽  
J.M. Pettifor
Keyword(s):  
Vitamin D ◽  
Calcium Deficiency ◽  
Deficiency Rickets

Early response to vitamin D2 in children with calcium deficiency rickets

2006 ◽  
Vol 149 (6) ◽  
pp. 840-844 ◽  
Author(s):  
Tom D. Thacher ◽  
Philip R. Fischer ◽  
Christian O. Isichei ◽  
John M. Pettifor
Keyword(s):  
Early Response ◽  
Calcium Deficiency ◽  
Vitamin D2 ◽  
Deficiency Rickets
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