Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform

2020 ◽  
Author(s):  
Keyword(s):  
Catalytic Subunit

INDUCTION OF ALTERNATIVE SPLICING OF TELOMERASE CATALYTIC SUBUNIT BY APOPTOTIC ENDONUCLEASE EndoG IN MURINE LIMPHOCYTES

Tsitologiya ◽  
2018 ◽  
Vol 60 (2) ◽  
pp. 104-115 ◽  
Author(s):  
D. D. Zhdanov ◽  
◽  
Yu. A. Gladilina ◽  
V. S. Orlova ◽  
D. V. Grishin ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Catalytic Subunit

scholarly journals Protein Kinase A Distribution in Meningioma

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1686 ◽  
Author(s):  
Caretta ◽  
Denaro ◽  
D’Avella ◽  
Mucignat-Caretta
Keyword(s):  
Brain Tissue ◽  
Catalytic Subunit ◽  
Therapeutic Interventions ◽  
Normal Brain ◽  
Local Concentration ◽  
Correlation Pattern ◽  
Catalytic Subunits ◽  
Tissue Specimens ◽  
Pka Catalytic Subunit

Deregulation of intracellular signal transduction pathways is a hallmark of cancer cells, clearly differentiating them from healthy cells. Differential intracellular distribution of the cAMP-dependent protein kinases (PKA) was previously detected in cell cultures and in vivo in glioblastoma and medulloblastoma. Our goal is to extend this observation to meningioma, to explore possible differences among tumors of different origins and prospective outcomes. The distribution of regulatory and catalytic subunits of PKA has been examined in tissue specimens obtained during surgery from meningioma patients. PKA RI subunit appeared more evenly distributed throughout the cytoplasm, but it was clearly detectable only in some tumors. RII was present in discrete spots, presumably at high local concentration; these aggregates could also be visualized under equilibrium binding conditions with fluorescent 8-substituted cAMP analogues, at variance with normal brain tissue and other brain tumors. The PKA catalytic subunit showed exactly overlapping pattern to RII and in fixed sections could be visualized by fluorescent cAMP analogues. Gene expression analysis showed that the PKA catalytic subunit revealed a significant correlation pattern with genes involved in meningioma. Hence, meningioma patients show a distinctive distribution pattern of PKA regulatory and catalytic subunits, different from glioblastoma, medulloblastoma, and healthy brain tissue. These observations raise the possibility of exploiting the PKA intracellular pathway as a diagnostic tool and possible therapeutic interventions.

scholarly journals The Isoform-Specific Region of the Na,K-ATPase Catalytic Subunit:  Role in Enzyme Kinetics and Regulation by Protein Kinase C†

Biochemistry ◽  
2004 ◽  
Vol 43 (51) ◽  
pp. 16174-16183 ◽  
Author(s):  
Marie-Josée Duran ◽  
Sandrine V. Pierre ◽  
Deborah L. Carr ◽  
Thomas A. Pressley
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Enzyme Kinetics ◽  
Specific Region ◽  
Catalytic Subunit ◽  
Kinase C
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