scholarly journals Osteoblastic Osteosarcoma

2020 ◽  
Author(s):  
2020 ◽  
Author(s):  
Rubina Sirri ◽  
Ranieri Verin ◽  
Alberto Perolo ◽  
Fernando Lunelli ◽  
Filippo Faccenda ◽  
...  

Author(s):  
ANDREA LUSVARGHI WITZEL ◽  
SHEYLA BATISTA BOLOGNA ◽  
THAÍS BORGUEZAN NUNES ◽  
JESSICA ELEN DA SILVA COSTA ◽  
JULIANA SEO ◽  
...  

1993 ◽  
Vol 128 (4) ◽  
pp. 367-372 ◽  
Author(s):  
Chizu Nakamoto ◽  
Hisamitsu Baba ◽  
Masaaki Fukase ◽  
Kiichiro Nakajima ◽  
Terutoshi Kimura ◽  
...  

The individual and combined effects of intact PTH, amino-terminal, and a series of truncated carboxyl-terminal PTH fragments on alkaline phosphatase activity were examined in dexamethasone-treated rat osteoblastic osteosarcoma cells ROS 17/2.8. Dexamethasone-induced alkaline phosphatase activity was inhibited not only by hPTH(1–84) and amino-terminal PTH fragment hPTH(1–34), but also by carboxyl-terminal PTH fragment hPTH(69–84) in a dose-related fashion. At 10−7 mol/1, hPTH(1–84) completely abolished dexamethasone-induced alkaline phosphatase activity, while hPTH(1–34) and hPTH(69–84) reduced alkaline phosphatase activity to 0.16±0.02 and 0.80±0.03 fold, respectively, of the control value obtained in the absence of PTH peptides. The combination of hPTH(1–34) and hPTH(69—84) resulted in reduction of alkaline phosphatase activity to the level obtained by hPTH(1-84). The shorter carboxyl-terminal PTH fragment hPTH(71–84) did not affect alkaline phosphatase activity or modulate the action of hPTH(1–34). The longer carboxyl-terminal PTH fragment hPTH(53-84) stimulated alkaline phosphatase activity up to 1.23±0.03 fold and partially blunted the inhibitory effect of hPTH(1–34) on alkaline phosphatase activity. These findings suggest that carboxyl-terminal PTH fragments could exert diverse effects on the target cells, depending on the length of deletion of amino-terminal amino acids of PTH molecule, and interact with amino-terminal PTH fragment. The two amino-terminal amino acids of hPTH(69–84) and the 53–68 portion of hPTH(53–84) might be responsible for the respective inhibitory and stimulatory effects of the peptides on alkaline phosphatase activity.


2009 ◽  
Vol 4 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Eloy A. Ituarte ◽  
Hector G. Ituarte ◽  
Akiko Iida-Klein ◽  
Theodore J. Hahn

Planta Medica ◽  
2004 ◽  
Vol 70 (10) ◽  
pp. 1003-1005 ◽  
Author(s):  
K. Wende ◽  
L. Krenn ◽  
I. Unterrieder ◽  
U. Lindequist

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